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Vitamin K and osteoporosis

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Vitamin K is required for bone health, probably in doses greater than conventional RDI levels.

There is reasonable but not conclusive evidence that vit.K supplements can help prevent osteopenic fractures, even if it does not necessarily increase BMD. Vitamin K should therefore be part of the nutritional cocktail for osteporosis prevention.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 309 , July 2009 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 2009

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References

1. Dam, H. The antihaemorrhagic factor of the chick. Biochem J. 1935;29:1273–1285.CrossRefGoogle Scholar
2. Shea, MK. et al. Update on the role of vitamin K in skeletal health. Nutr Rev. 2008 Oct;66(10):549–57.CrossRefGoogle ScholarPubMed
3. Lanham-New, SA. Importance of calcium, vitamin D and vitamin K for osteoporosis prevention and treatment. Proc Nutr Soc. 2008 May;67(2):163–76.Google Scholar
4. Cashman, KD. et al. Does high vitamin K1 intake protect against bone loss in later life? Nutr Rev. 2008 Sep;66(9):532–8.CrossRefGoogle ScholarPubMed
5. Bügel, S. Vitamin K and bone health. Proc Nutr Soc. 2003 Nov;62(4):839–43.CrossRefGoogle ScholarPubMed
6. Gundberg, CM. et al. Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab. 1998 Sep;83(9):3258–66.Google ScholarPubMed
7. Eastell, R. et al. Biomarkers of bone health and osteoporosis risk. Proc Nutr Soc. 2008 May;67(2):157–62.Google Scholar
8. Macdonald, HM. et al. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. Am J Clin Nutr. 2008 May;87(5):1513–20.Google Scholar
9. O'Connor, E. et al. Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br J Nutr. 2007 Apr;97(4):661–6.Google Scholar
10. van Summeren, MJ. et al. Vitamin K status is associated with childhood bone mineral content. Br J Nutr. 2008 Oct;100(4):852–8.CrossRefGoogle ScholarPubMed
11. Kuwabara, A. et al. High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int. 2009 Jun;20(6):935–42.Google Scholar
12. Duggan, P. et al. Vitamin K status in patients with Crohn's disease and relationship to bone turnover. Am J Gastroenterol. 2004 Nov;99(11):2178–85.Google Scholar
13. Conway, SP. et al. Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Pediatrics. 2005 May;115(5):1325–31.Google Scholar
14. Horiuchi, T. et al. Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density. J Bone Miner Metab. 2004;22(3):236–40.Google Scholar
14. Sato, Y. et al. Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson's disease. Arch Phys Med Rehabil. 2002 Jan;83(1):86–91.Google Scholar
15. Sato, Y. et al. Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease. Arch Phys Med Rehabil. 2005 Mar;86(3):576–81.Google Scholar
16. Sato, Y. et al. Vitamin K deficiency and osteopenia in disuse-affected limbs of vitamin D-deficient elderly stroke patients. Am J Phys Med Rehabil. 1999 Jul-Aug;78(4):317–22.CrossRefGoogle ScholarPubMed
17. Tsugawa, N. et al. Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab. 2008;26(1):79–85.Google Scholar
18. Booth, SL. et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr. 2000 May;71(5):1201–8.Google Scholar
19. Feskanich, D. et al. Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr. 1999 Jan;69(1):74–9.CrossRefGoogle ScholarPubMed
20. Hodges, SJ. et al. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993 Oct;8(10):1241–5.Google Scholar
21. Rejnmark, L. et al. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos Int. 2006;17(8):1122–32.Google Scholar
22. Kawana, K. et al. Circulating levels of vitamin K1, menaquinone-4, and menaquinone-7 in healthy elderly Japanese women and patients with vertebral fractures and patients with hip fractures. Endocr Res. 2001 Aug;27(3):337–43.Google Scholar
23. Malyszko, JS. et al. Protein Z and vitamin K in kidney disease. Rocz Akad Med Bialymst. 2004;49:197–200 Google Scholar
24. Malyszko, J. et al. Vitamin K status in relation to bone metabolism in patients with renal failure. Am J Nephrol. 2002 Sep-Dec;22(5–6):504–8.Google Scholar
25. Nimptsch, K. et al. The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype. Br J Nutr. 2009 Jun;101(12):1812–20.Google Scholar
26. Sogabe, N. et al. Nutritional effects of gamma-glutamyl carboxylase gene polymorphism on the correlation between the vitamin K status and gamma-carboxylation of osteocalcin in young males. J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):419–25.Google Scholar
27. Koitaya, N. et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15–21.CrossRefGoogle ScholarPubMed
28. Shiraki, M. et al. Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporosis: a randomized prospective study. J Bone Miner Metab. 2009;27(3):333–40.Google Scholar
29. Binkley, N. et al. Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res. 2009 Jun;24(6):983–91.Google Scholar
30. Volpe, SL. et al. Vitamin K supplementation does not significantly impact bone mineral density and biochemical markers of bone in pre-and perimenopausal women. Nutr Res. 2008 Sep;28(9):577–82.Google Scholar
31. Bügel, S. et al. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Br J Nutr. 2007 Feb;97(2):373–80.Google Scholar
32. Yasui, T. et al. Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women. Gynecol Endocrinol. 2006 Aug;22(8):455–9.Google Scholar
33. Purwosunu, Y. et al. Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. J Obstet Gynaecol Res. 2006 Apr;32(2):230–4.Google Scholar
34. Nicolaidou, P. et al. The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis. Eur J Pediatr. 2006 Aug;165(8):540–5.Google Scholar
35. Iketani, T. et al. Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. Psychiatry Res. 2003 Mar 25;117(3):259–69.Google Scholar
36. Yonemura, K. et al. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis. 2004 Jan;43(1):53–60.Google Scholar
37. Sugimoto, T. et al. Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients. J Int Med Res. 2002 Nov-Dec;30(6):566–75.Google Scholar
38. Bern, M. Observations on possible effects of daily vitamin K replacement, especially upon warfarin therapy. JPEN J Parenter Enteral Nutr. 2004 Nov-Dec;28(6):388–98.Google Scholar
39. Asakura, H. et al. Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. Osteoporos Int. 2001 Dec;12(12):996–1000.Google Scholar
40. Binkley, NC. et al. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Am J Clin Nutr. 2002 Nov;76(5):1055–60.Google Scholar
41. Olson, JA. Recommended dietary intakes (RDI) of vitamin K in humans. Am J Clin Nutr. 1987 Apr;45(4):687–92.Google Scholar
42. Prynne, CJ. et al. Intake and sources of phylloquinone (vitamin K(1)) in 4-year-old British children: comparison between 1950 and the 1990s. Public Health Nutr. 2005 Apr;8(2):171–80.Google Scholar
43. Duggan, P. et al. Phylloquinone (vitamin K1) intakes and food sources in 18-64-year-old Irish adults. Br J Nutr. 2004 Jul;92(1):151–8.Google Scholar
44. Amizuka, N. et al. [The interplay of magnesium and vitamin K2 on bone mineralization] Clin Calcium. 2005 Jul;15(7):57–61.Google Scholar
45. Bonjour, JP. et al. Minerals and vitamins in bone health: the potential value of dietary enhancement. Br J Nutr. 2009 Jun;101(11):1581–96.CrossRefGoogle ScholarPubMed