Guest editors: Ed Cohen (Imperial College, London, e.cohen@imperial.ac.uk) and Thibault Lagache (Institut Pasteur, Paris, thibault.lagache@pasteur.fr) 

Scope: Imaging technologies play a vital role in studying biological structures and interactions for biomedical and clinical investigations. These interactions manifest themselves through complex spatial patterns that need to be detected and quantified for scientific advancement; creating an urgent need to innovate the necessary mathematical, statistical and machine learning tools.

The aim of this special issue is to cover recent advances in biological imaging and quantitative spatial analysis, linking fields from localization microscopy to pathology, multiplexed imaging to spatial transcriptomics; paving the way to an in-depth description and understanding of spatial patterns, from molecules to cells and tissues.

Fields covered:

Mathematical modeling, Statistics & Machine Learning
Fluorescence imaging of the cell & SMLM
Multiplexed Imaging, Tissue organization & Pathology