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The Implications of Memory Research and ‘Memory Erasers’: A Conversation with Yadin Dudai

  • Joelle M. Abi-Rached (a1) and Yadin Dudai (a2)

In this conversation, the world-renowned neurobiologist Yadin Dudai discusses the latest advances in memory research, specifically the discovery of memory ‘erasure’ associated with the inhibition of an enzyme called PKMzeta. The conversation tackles the reductionist method in scientific inquiry, the mind/brain dilemma, the problematics of animal models in memory research, and the therapeutic implications of this groundbreaking discovery.

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Y. Dudai (2004). The neurosciences: The danger that we will think that we have understood it all. In D. Rees and S. Rose (Eds), The New Brain Sciences: Perils and prospects, 167–180. Cambridge: Cambridge UP.

J. Illes (2007). Not forgetting forgetting. American Journal of Bioethics, 7(9), 12.

T.R. Insel (2007). From animal models to model animals. Biological Psychiatry, 62, 13371339.

D.S. Ling , L.S. Benardo , P.A. Serrano , N. Blace , M.T. Kelly , J.F. Crary et al. (2002). Protein kinase Mzeta is necessary and sufficient for LTP maintenance. Nature Neuroscience, 5, 295296.

T. Nagel (1974). What is it like to be a bat? Philosophical Review, 83, 435450.

E. Pastalkova , P. Serrano , D. Pinkhasove , E. Wallace , A.A. Fenton , & T.C. Sacktor (2006). Storage of spatial information by the maintenance mechanism of LTP. Science, 313, 11411144.

R. Shema , T.C. Sacktor , & Y. Dudai (2007). Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Science, 317(5840), 951953.

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  • ISSN: 1745-8552
  • EISSN: 1745-8560
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