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Four Paradigms of Clinical Research and Research Oversight

  • EZEKIEL J. EMANUEL (a1) and CHRISTINE GRADY (a1)
Abstract

The understanding of appropriate ethical protections for participants of biomedical research has not been static. It has evolved over time, with the evolution of biomedical research as well as social values. Since World War II, there have been four major paradigms of research and research oversight operative in the United States (Table 1). These paradigms incorporate different values and provide different approaches to research oversight and the protection of research participants.

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Cambridge Quarterly of Healthcare Ethics
  • ISSN: 0963-1801
  • EISSN: 1469-2147
  • URL: /core/journals/cambridge-quarterly-of-healthcare-ethics
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