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How to conduct implementation trials and multicentre studies in the emergency department

  • Ian G. Stiell (a1) (a2), Jeffrey J. Perry (a1) (a2), Jamie Brehaut (a2) (a3), Erica Brown (a2), Janet A. Curran (a4), Marcel Emond (a5), Corinne Hohl (a6), Monica Taljaard (a2) (a3) and Andrew D. McRae (a2) (a7)...
Abstract
Objective

The objective of Panel 2b was to present an overview of and recommendations for the conduct of implementation trials and multicentre studies in emergency medicine.

Methods

Panel members engaged methodologists to discuss the design and conduct of implementation and multicentre studies. We also conducted semi-structured interviews with 37 Canadian adult and pediatric emergency medicine researchers to elicit barriers and facilitators to conducting these kinds of studies.

Results

Responses were organized by themes, and, based on these responses, recommendations were developed and refined in an iterative fashion by panel members.

Conclusions

We offer eight recommendations to facilitate multicentre clinical and implementation studies, along with guidance for conducting implementation research in the emergency department. Recommendations for multicentre studies reflect the importance of local study investigators and champions, requirements for research infrastructure and staffing, and the cooperation and communication between the coordinating centre and participating sites.

Objectif

Le groupe de travail 2b avait pour buts de donner un aperçu de la marche des essais de mise en œuvre et des études multicentriques effectués au service des urgences (SU), et d’élaborer des recommandations en la matière.

Méthodes

Les membres du groupe ont fait appel à des spécialistes de la méthodologie afin d’échanger des idées sur la conception des études sur la mise en œuvre et des études multicentriques ainsi que sur la marche à suivre. Les premiers ont également réalisé des entrevues semi-structurées avec 37 chercheurs canadiens en médecine d’urgence tant adulte que pédiatrique dans le but de faire ressortir les obstacles à la réalisation de ce type d’études ainsi que les facteurs facilitants.

Résultats

L’équipe a groupé les réponses par thème, élaboré des recommandations en tenant compte des réponses reçues, puis amélioré ces recommandations selon un processus itératif.

Conclusions

Le groupe présente huit recommandations visant à faciliter la marche des études cliniques multicentriques ou des études sur la mise en œuvre, et donne des indications sur la manière d’effectuer de la recherche sur la mise en œuvre au SU. Les recommandations sur les études multicentriques tiennent compte de l’importance des chercheurs et des chefs de file locaux, des exigences relatives aux infrastructures et au personnel nécessaires à la recherche ainsi que de la nécessité d’établir une bonne coopération et des communications fréquentes entre les centres de coordination et les centres de recherche participants.

Copyright
Corresponding author
Correspondence to: Dr. Ian Stiell, Clinical Epidemiology Unit, F6, 1053 Carling Avenue, Ottawa, ON K1Y 4E9; Email: istiell@ohri.ca
References
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Canadian Journal of Emergency Medicine
  • ISSN: -
  • EISSN: 1481-8035
  • URL: /core/journals/canadian-journal-of-emergency-medicine
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