Hostname: page-component-848d4c4894-p2v8j Total loading time: 0 Render date: 2024-06-08T04:55:26.190Z Has data issue: false hasContentIssue false

Tunnelled central venous catheter–induced thrombosis: a rare case of superior vena cava syndrome

Published online by Cambridge University Press:  21 May 2015

Sandeep K. Aggarwal*
Affiliation:
Schulich School of Medicine, University of Western Ontario, London, Ont.
William McCauley
Affiliation:
Department of Emergency Medicine, University of Western Ontario, LondonOnt.
*
3530 Irwin Crt., Mississauga ON L5L 4W4; 905 820-7693, saggarwal2006@meds.uwo.ca

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Thrombotic venous obstruction in patients with a tunnelled central venous catheter is a cause of superior vena cava syndrome that is not routinely encountered by emergency physicians. Diagnosis requires identifying patients at risk (e.g., those under treatment for cancer and those who have a tunnelled central venous catheter), recognizing the signs and symptoms of superior vena cava syndrome, usually dyspnea and dilated neck or thoracic veins, and imaging the venous obstruction using computer tomography or sonography. Management involves anticoagulation and local thrombolytic administration. We report the case of a 28-year-old woman who presented with a 2-day history of face, chest and bilateral arm swelling who had been receiving maintenance chemotherapy for acute lymphoblastic leukemia through a Hickman® catheter. This case demonstrates the need to be vigilant for thrombus formation in patients with long-term, indwelling central venous catheters.

Type
Case Report • Observations de cas
Copyright
Copyright © Canadian Association of Emergency Physicians 2005

References

1.Moureau, N, Poole, S, Murdock, MA, Gray, SM, Semba, CP. Central venous catheters in home infusion care: outcomes analysis in 50,470 patients. J Vasc Interv Radiol 2002;13:1009–16.Google Scholar
2.Schechter, MM. The superior vena cava syndrome. Am J Med Sci 1954; 227:4656.Google Scholar
3.Hunter, W. The history of an aneurysm of the aorta with some remarks on aneurysms in general. Med Obstet Soc Phys (London) 1757;1:323.Google Scholar
4.Wudel, JL Jr, Nesbitt, JC. Superior vena cava syndrome. Curr Treat Options Oncol 2001;2:7791.Google Scholar
5.De Cicco, M, Matovic, M, Balestreri, L, Panarello, G, Fantin, D, Morassut, S, et al.Central venous thrombosis: an early and frequent complication in cancer patients bearing long-term silastic catheter. A prospective study. Thromb Res 1997;86:101–13.Google Scholar
6.Cimochowski, GE, Worley, E, Rutherford, WE, Sartain, J, Blondin, J, Harter, H. Superiority of the internal jugular over the subclavian access for temporary dialysis. Nephron 1990;54:154–61.Google Scholar
7.Puel, V, Caudry, M, Le Metayer, P, Baste, JC, Midy, D, Marsault, C. Superior vena cava thrombosis related to catheter malposition in cancer chemotherapy given through implanted ports. Cancer 1993;72:2248–52.Google Scholar
8.Stanislav, GV, Fitzgibbons, RJ Jr, Bailey, RT Jr, Mailliard, JA, Johnson, PS, Feole, JB. Reliability of implantable central venous access devices in patients with cancer. Arch Surg 1987;122: 1280–3.CrossRefGoogle ScholarPubMed
9.Schwarz, RE, Coit, DG, Groeger, JS. Transcutaneously tunneled central venous lines in cancer patients: an analysis of device-related morbidity factors based on prospective data collection. Ann Surg Oncol 2000;7:441–9.Google Scholar
10.Nightingale, CE, Norman, A, Cunningham, D, Young, J, Webb, A, Filshie, J. A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy. Eur J Cancer 1997;33:398403.CrossRefGoogle ScholarPubMed
11.Namyslowski, J, Trerotola, SO, McKusky, M, Johnson, MS, Shah, H, Kraus, M. Retrospective analysis of blood flow rates via tunneled right and left internal jugular vein dialysis catheters. Cardiovasc Intervent Radiol 1999;22 (suppl 2):S91.Google Scholar
12.Kuter, DJ. Thrombotic complications of central venous catheters in cancer patients. Oncologist 2004;9:207–16.Google Scholar
13.Curelaru, I, Bylock, A, Gustavsson, B, Hultman, E, Linder, LE, Stefansson, T, et al.Dynamics of thrombophlebitis in central venous catheterization via basilic and cephalic veins. Acta Chir Scand 1984;150:285–93.Google Scholar
14.Lokich, JJ, Becker, B. Subclavian vein thrombosis in patients treated with infusion chemotherapy for advanced malignancy. Cancer 1983;52:1586–9.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
15.Markman, M. Diagnosis and management of superior vena cava syndrome. Cleve Clin J Med 1999;66:5961.CrossRefGoogle ScholarPubMed
16.Sculier, JP, Feld, R. Superior vena cava obstruction syndrome: recommendations for management. Cancer Treat Rev 1985;12: 209–18.Google Scholar
17.Hoch, JR. Management of the complications of long-term venous access. Semin Vasc Surg 1997;10:135–43.Google ScholarPubMed
18.Lowell, JA, Bothe, A Jr. Central venous catheter related thrombosis. Surg Oncol Clin North Am 1995;4:479–92. CrossRefGoogle ScholarPubMed
19.Adelstein, DJ, Hines, JD, Carter, SG, Sacco, D. Thromboembolic events in patients with malignant superior vena cava syndrome and the role of anticoagulation. Cancer 1988;62:2258–62.Google Scholar
25.Wudel, JL Jr, Nesbitt, JC. Superior vena cava syndrome. Curr Treat Options Oncol 2001;2:7791.Google Scholar
20.Weber, T, Huemer, G, Tschernich, H, Kranz, A, Imhof, M, Sladen, RN. Catheter-induced thrombus in the superior vena cava diagnosed by transesophageal echocardiography. Acta Anaesthesiologica Scandinavica 1998;42:1227–30.CrossRefGoogle ScholarPubMed
21.Nazarian, GK, Foshager, MC. Color Doppler sonography of the thoracic inlet veins. Radio Graphics 1995;15:1357–71.Google Scholar
23.Demondion, X, Boutry, N, Drizenko, A, Paul, C, Francke, JP, Cotton, A. Thoracic outlet: anatomic correlation with MR imaging. Am J Roentgenol 2000;175:417–22.Google Scholar
24.Shinde, TS, Lee, VS, Rofsky, NM, Krinksy, GA, Weinreb, JC. Three-dimensional Gadolinium-enhanced MR venographic evaluation of patency of central veins in the thorax: initial experience. Radiology 1999;213:555–60.CrossRefGoogle ScholarPubMed
22.Chen, JC, Bongard, F, Klein, SR. A contemporary perspective on superior vena cava syndrome. Am J Surg 1990;160:207–11.Google Scholar
26.Hirsh, J, Dalen, J, Guyatt, G. The sixth (2000) ACCP guidelines for antithrombotic therapy for prevention and treatment of thrombosis. American College of Chest Physicians. Chest 2001;119 (suppl):1S–2S.Google Scholar
27.Bern, MM, Lokich, JJ, Wallach, SR, Bothe, A Jr, Benotti, PN, Arkin, CF, et al.Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective trial. Ann Intern Med 1990;112:423–8.CrossRefGoogle ScholarPubMed
28.Boraks, P, Seale, J, Price, J, Bass, G, Ethell, M, Keeling, D, et al.Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies. Br J Haematol 1998;101:483–6.Google Scholar
29.Montreal, M, Alastrue, A, Rull, M, Mira, X, Muxart, J, Rosell, R, et al.Upper extremity deep venous thrombosis in cancer patients with venous access devices — prophylaxis with a low molecular weight heparin (Fragmin). Thromb Haemost 1996;75:21–3.Google Scholar
30.Eastman, ME, Khorsand, M, Maki, DG, Williams, EC, Kim, K, Sondel, PM, et al.Central venous device-related infection and thrombosis in patients treated with moderate dose continuousinfusion interleukin-2. Cancer 2001;91:806–14.Google Scholar
31.Heaton, DC, Han, DY, Inder, A. Minidose (1 mg) warfarin as prophylaxis for central vein catheter thrombosis. Intern Med J 2002;32:84–8.Google Scholar
32.Teichgräber, UK, Gebauer, B, Benter, T, Wagner, HJ. Central venous access catheters: radiological management of complications. Cardiovasc Intervent Radiol 2003;26:321–33.Google Scholar
33.Mewissen, MW, Seabrook, GR, Meissner, MH, Cynamon, J, Labropoulos, N, Haughton, SH. Catheter-directed thrombolysis for lower extremity deep venous thrombosis: report of a national multicenter registry. Radiology 1999;211:3949.CrossRefGoogle ScholarPubMed
34.Smith, NL, Ravo, B, Soroff, HS, Khan, SA. Successful fibrinolytic therapy for superior vena cava thrombosis secondary to long-term total parenteral nutrition. JPEN: J Parenteral Enteral Nutr 1985;9:55–7.CrossRefGoogle ScholarPubMed
35.Gray, BH, Olin, JW, Graor, RA, Young, JR, Bartholomew, JR, Ruschhaupt, WF. Safety and efficacy of thrombolytic therapy for superior vena cava syndrome. Chest 1991;99:54–9.Google Scholar
36.Lawson, M, Bottino, JC, Hurtubise, MR. The use of urokinase to restore patency of occluded central venous catheters. Am J Intraven Ther Clin Nutr 1982;9:2932.Google Scholar
37.Gray, RJ, Levitin, A, Buck, D, Brown, LC, Sparling, YH, Jablonski, KA, et al.Percutaneous fibrin sheath stripping versus transcatheter urokinase infusion for malfunctioning well-positioned tunneled central venous dialysis catheters: a prospective, randomized trial. J Vasc Interv Radiol 2000;11:1121–9.Google Scholar
38.Savader, SJ, Ehrman, KO, Porter, DJ, Haikal, LC, Oteham, AC. Treatment of hemodialysis catheter-associated fibrin sheaths by rt-PA infusion: critical analysis of 124 procedures. J Vasc Interv Radiol 2001;12:711–5.Google Scholar
39.Whigham, CJ, Lindsey, JI, Goodman, CJ, Fisher, RG. Venous port salvage utilizing low dose tPA. Cardiovasc Intervent Radiol 2002;25:513–6.CrossRefGoogle ScholarPubMed
40.McGee, DC, Gould, MK. Preventing complications of central venous catheterization. N Engl J Med 2003;348(12):1123–33.Google Scholar