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Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics

Published online by Cambridge University Press:  28 June 2019

Kazuhiro Shiraga Open the ORCID record for Kazuhiro Shiraga [Opens in a new window] ,
Kojiro Ono ,
Ryo Inuzuka ,
Hiroko Asakai ,
Takumi Ookubo ,
Akira Shirayama ,
Kouji Higashi  and
Hiromichi Nakajima
Kazuhiro Shiraga
Affiliation:
Department of Cardiology, Chiba Children’s Hospital, Chiba, Japan Department of Pediatrics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
Kojiro Ono
Affiliation:
Department of Radiology, Chiba Children’s Hospital, Chiba, Japan Division of Fundamental Engineering, Graduate School of Science and Engineering, Chiba University, Chiba, Japan
Ryo Inuzuka
Affiliation:
Department of Pediatrics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
Hiroko Asakai
Affiliation:
Department of Pediatrics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
Takumi Ookubo
Affiliation:
Department of Radiology, Chiba Children’s Hospital, Chiba, Japan
Akira Shirayama
Affiliation:
Department of Radiology, Chiba Children’s Hospital, Chiba, Japan
Kouji Higashi
Affiliation:
Department of Cardiology, Chiba Children’s Hospital, Chiba, Japan
Hiromichi Nakajima*
Affiliation:
Department of Cardiology, Chiba Children’s Hospital, Chiba, Japan
*
Author for correspondence: Hiromichi Nakajima, Department of Cardiology, Chiba Children’s Hospital, 579-1 Hetachou, Midori-ku, Chiba city, Chiba 2660007 Japan. Tel: +81-43-292-2111; Fax: +81-43-292-3815; E-mail: h.nkjm11@pref.chiba.lg.jp
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Abstract

Introduction:

Liver fibrosis and cirrhosis are one of the critical complications in Fontan patients. However, there are no well-established non-invasive and quantitative techniques for evaluating liver abnormalities in Fontan patients. Intravoxel incoherent motion diffusion-weighted imaging with MRI is a non-invasive and quantitative method to evaluate capillary network perfusion and molecular diffusion. The objective of this study is to assess the feasibility of intravoxel incoherent motion imaging in evaluating liver abnormalities in Fontan children.

Materials and Methods:

Five consecutive Fontan patients and four age-matched healthy volunteers were included. Fontan patients were 12.8 ± 1.5 years old at the time of MRI scan. Intravoxel incoherent motion imaging parameters (D, D*, and f values) within the right hepatic lobe were compared. Laboratory test, ultrasonography, and cardiac MRI were also conducted in the Fontan patients. Results of cardiac catheterization conducted within one year of the intravoxel incoherent motion imaging were also examined.

Results:

In Fontan patients, laboratory test and liver ultrasonography showed almost normal liver condition. Cardiac catheter and MRI showed good Fontan circulation. Cardiac index was 2.61 ± 0.23 L/min/m2. Intravoxel incoherent motion imaging parameters D, D*, and f values were lower in Fontan patients compared with controls (D: 1.1 ± 0.0 versus 1.3 ± 0.2 × 10−3 mm2/second (p = 0.04), D*: 30.8 ± 24.8 versus 113.2 ± 25.6 × 10−3 mm2/second (p < 0.01), and f: 13.2 ± 3.1 versus 22.4 ± 2.4% (p < 0.01), respectively).

Conclusions:

Intravoxel incoherent motion imaging is feasible for evaluating liver abnormalities in children with Fontan circulation.

Keywords

IVIMintravoxel incoherent motionFontanliver perfusionliver fibrosisliver cirrhosis
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 7 , July 2019 , pp. 898 - 903
Copyright
© Cambridge University Press 2019 

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