Skip to main content
×
Home

Spontaneous ventricular thrombosis in patients with inflammatory bowel disease

  • Stella Pak (a1), Juan Linares (a1), Yan Yatsynovich (a1), David Cha (a2), Dexter Nye (a2), Diana Kaminski (a2) and Jillian Costello (a3)...
Abstract
Abstract

Inflammatory bowel disease is closely associated with an increased risk for thrombotic events. Thrombosis mostly occurs in the extremities, lungs, and liver; but it can also occur in the ventricles of the heart. The primary goal of this article is to increase awareness of the risk for ventricular thrombosis in this patient population among healthcare professionals and, thus, appropriate prompt use of thromboprophylaxis therapy for these patients during acute flare-ups. Early diagnosis and intervention are critical for ventricular thrombosis to prevent systemic embolisation of the thrombus. Concisely, inflammatory bowel disease predisposes to the development of thrombi. A low threshold for the use of imaging studies to detect such thrombi is warranted.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Spontaneous ventricular thrombosis in patients with inflammatory bowel disease
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Spontaneous ventricular thrombosis in patients with inflammatory bowel disease
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Spontaneous ventricular thrombosis in patients with inflammatory bowel disease
      Available formats
      ×
Copyright
Corresponding author
Correspondence to: S. Pak, Department of Medicine, Kettering Medical Center, 3535 Southern Blvd, Kettering, OH 45429, United States of America. Tel: +937 298 4331; Fax: (937) 395-8399; E-mail: Stella.Pak@rockets.utoledo.edu
References
Hide All
1. Stokman PJ, Nandra CS, Richard Asinger BcW. Left ventricular thrombus. Curr Treat Options Cardiovasc Med 2001; 3: 515521.
2. Egolum UO, Stover DG, Lenihan D, et al. Intracardiac thrombus: diagnosis, complications, and management. Am J Med Sci 2013; 345: 391395.
3. Yamamoto K, Ikeda U, Furuhashi K, Irokawa M, Nakayama T, Shimada K. The coagulation system is activated in idiopathic cardiomyopathy. J Am Coll Cardiol 1995; 25: 16341640.
4. Lisitsyna T, Alekberova Z, Ovcharov P, Volkov A, Korsakova J, Nasonov E. Left ventricular intracardiac thrombus in a patient with Behçet disease successfully treated with immunosuppressive agents without anticoagulation: a case report and review of the literature. Rheumatol Int 2015; 35: 19311935.
5. Sabzi F, Faraji R. Large in-transient left ventricular thrombus due to anabolic steroid-induced cardiomyopathy. Indian J Crit Care Med 2017; 21: 5154.
6. Malik SA, Malik S, Dowsley TF, Singh B. Left ventricular thrombus as a complication of clozapine-induced cardiomyopathy: a case report and brief literature review. Case Reports Cardiol. 2015; 2015: 5.
7. Cousin E, Scholfield M, Faber C, Caldeira C, Guglin M. Treatment options for patients with mobile left ventricular thrombus and ventricular dysfunction: a case series. Hear Lung Vessel 2014; 6: 8891.
8. Oeser C, Andreas M, Rath C, Habertheuer A, Kocher A. Left ventricular thrombus in a patient with cutaneous T-cell lymphoma, hypereosinophilia and Mycoplasma pneumoniae infection – a challenging diagnosis: a case report. J Cardiothorac Surg 2015; 10: 21.
9. Giannotta M, Tapete G, Emmi G, Silvestri E, Milla M. Thrombosis in inflammatory bowel diseases: what’s the link? Thromb J 2015; 13: 14.
10. Freeman HJ. Venous thrombosis with inflammatory bowel disease. World J Gastroenterol 2008; 14: 991993.
11. Saleh T. Left ventricular thrombosis in ulcerative colitis. Case Rep Gastroenterol 2010; 4: 220223.
12. Urgesi R, Zampaletta C, Masini A, et al. Spontaneous right ventricular thrombus in a patient with active ulcerative colitis and protein C deficiency: a review with a case report. Eur Rev Med Pharmacol Sci 2010; 14: 455463.
13. Chin WW, Van Tosh A, Hecht SR, Berger M. Left ventricular thrombus with normal left ventricular function in ulcerative colitis. Am Heart J 1988; 116: 562563.
14. Iyer A, Marney L, Ipp S, Bough G, McCoombe D, Tam R. Recurrent left ventricular thrombus in Crohn’s disease: a rare presentation. Asian Cardiovasc Thorac Ann 2014; 22: 8688.
15. Rasalingam R, Saeed IM, Woodard PK, Perez JE. Left ventricular thrombus in the setting of normal left ventricular function in patients with Crohn’s disease. Echocardiography 2016; 33: 145149.
16. Koneru S, Koshy G, Sharp C, Khalafallah AA. Hypereosinophilic syndrome associated with ulcerative colitis presenting with recurrent Loeffler’s endocarditis and left ventricular thrombus treated successfully with immune suppressive therapy and anticoagulation. BMJ Case Rep 2013; 2013: 2013200919.
17. O’Sullivan CJ, Eberli FR. Left ventricular thrombus formation after acute myocardial infarction: vigilance still required in the modern era. Swiss Med Wkly 2015; 145: w14158.
18. Bryant RV, Jairath V, Curry N, Travis SP. Thrombosis in inflammatory bowel disease: are we tiloring prophylaxis to those most at risk? J Crohns Colitis 2014; 8: 166171.
19. Dwyer JP, Javed A, Hair CS, Moore GT. Venous thrombosis and underutilisation of anticoagulant thromboprophylaxis in hospitalised patients with inflammatory bowel disease. Intern Med J 2014; 44: 779784.
20. Papa A, Gerardi V, Marzo M, Felice C, Rapaccini GL, Gasbarrini A. Venous thrombosis in patients with inflammatory bowel disease: focus on prevention and treatment. World J Gastroenterol 2014; 20: 31733179.
21. Habash F, Vallurupalli S. Challenges in management of left ventricular thrombus. Ther Adv Cardiovasc Dis 2017; 11: 203213.
22. Weinsaft JW, Kim HW, Shah DJ, et al. Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction. J Am Coll Cardiol 2008; 52: 148157.
23. Attili AK, Schuster A, Nagel E, Reiber JH, van der Geest RJ. Quantification in cardiac MRI: advances in image acquisition and processing. Int J Cardiovasc Imaging 2010; 26 (Suppl 1): 2740.
24. Vaggar JN, Gadhinglajkar S, Pillai V, Sreedhar R, Cahndran R, Roy S. Echocardiographic detection of free-floating thrombus in left ventricle during coronary artery bypass grafting. Ann Card Anaesth 2015; 18: 579583.
25. Roifman I, Connelly KA, Wright GA, Wijeysundera HC. Echocardiography vs. cardiac magnetic resonance imaging for the diagnosis of left ventricular thrombus: a systematic review. Can J Cardiol 2015; 31: 785791.
26. Manning WJ, Weintraub RM, Waksmonski CA, et al. Accuracy of transesophageal echocardiography for identifying left atrial thrombi. A prospective, intraoperative study. Ann Intern Med 1995; 123: 817822.
27. Weinsaft JW, Kim HW, Crowley AL, et al. LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement cardiovascular magnetic resonance imaging. JACC Cardiovasc Imaging 2011; 4: 702712.
28. Gulsin G, Serna S, Morris C, Taher A, Loke I. Takotsubo cardiomyopathy with left ventricular thrombus presenting as critical limb ischaemia. Oxf Med Case Reports 2016; 2016: 195198.
29. Kassop D, Donovan MS, Cheezum MK, et al. Cardiac masses on cardiac CT: a review. Curr Cardiovasc Imaging Rep 2014; 7: 9281.
30. Lee H-J, Kim H-L, Hwang D, et al. Huge left ventricular thrombus and apical ballooning associated with recurrent massive strokes in a septic shock patient. Korean J Crit Care Med 2016; 31: 3943.
31. Unai S, Hirose H, Entwistle JW 3rd, Samuels LE. Resolution of hemolysis from pump thrombus during left ventricular assist device exchange. World J Clin Cases 2014; 2: 373376.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 5
Total number of PDF views: 23 *
Loading metrics...

Abstract views

Total abstract views: 62 *
Loading metrics...

* Views captured on Cambridge Core between 20th November 2017 - 11th December 2017. This data will be updated every 24 hours.