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Modifying layered double hydroxide nanoparticles for tumor imaging and therapy

Published online by Cambridge University Press:  01 January 2024

Li Li ,
Bei Li ,
Wenyi Gu  and
Zhi Ping Xu
Li Li
Affiliation:
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Bei Li
Affiliation:
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Wenyi Gu
Affiliation:
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Zhi Ping Xu*
Affiliation:
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
*
*gordonxu@uq.edu.au
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Abstract

Tumor theranostics (a portmanteau of therapeutics and diagnostics) is now achieved in various ways with complex nanoparticle systems. Layered double hydroxide (LDH) nanoparticles are effective at drug/gene delivery and as imaging agents in potential tumor theranostics. This mini-review paper summarizes recent progress in developing LDH nanoparticles as a pH-sensitive magnetic resonance imaging (MRI) contrast agent, as a positron emission tomography (PET) imaging agent, and as a co-delivery platform for two therapeutic agents for tumor diagnosis and therapy. These results have indicated clearly the potential application of LDH nanoparticles for simultaneous diagnosis and treatment of cancers.

Keywords

Co-delivery of Therapeutic AgentsImaging AgentLayered Double HydroxideMRIPETTumor Theranostics
Type
Research Article
Information
Clays and Clay Minerals , Volume 67 , Issue 1 , 15 February 2019 , pp. 72 - 80
Copyright
Copyright © Clay Minerals Society 2019

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