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Beyond the pill: new medication delivery options for ADHD

Published online by Cambridge University Press:  07 July 2017

Andrew J. Cutler  and
Gregory W. Mattingly
Andrew J. Cutler*
Affiliation:
Chief Medical Officer, Florida Clinical Research Center, Bradenton, Florida
Gregory W. Mattingly
Affiliation:
Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri Midwest Research Group, Weldon Spring, Missouri
*
*Address for correspondence: Andrew J. Cutler, Florida Clinical Research Center, 8043 Cooper Creek Boulevard, Suite 107, Bradenton, Florida 34201. (Email: acutler@flcrc.com)
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Abstract

Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules. This is especially true for attention-deficit/hyperactivity disorder (ADHD), which is one of the most common chronic pediatric conditions and often involves children with a variety of overlapping physical, psychological, or neurodevelopmental disorders. A special challenge for developing alternative dosage forms for ADHD treatment is the incorporation of a once-daily long-acting formulation. Traditional ADHD medication formulations have been limited, and issues surrounding prescribed dosing regimens—including poor medication adherence, difficulty swallowing, and the lack of dosing titration options—persist in ADHD treatment. In other disease areas, the development of alternative formulations has provided options for patients who have issues with consuming solid dosage forms, particularly children and individuals with developmental disorders. In the light of these new developments, several alternative formulations for ADHD medications are under development or have recently become available. This article reviews the various strategies for developing alternative dosage forms in other disease areas and discusses the application of these strategies in ADHD treatment. Alternative dosage forms may increase medication adherence, compliance, and patient preference and, therefore, improve the overall treatment for ADHD.

Keywords

Attention-deficit/hyperactivity disorderformulationstimulant
Type
Review Articles
Information
CNS Spectrums , Volume 22 , Issue 6 , December 2017 , pp. 463 - 474
Copyright
© Cambridge University Press 2016 

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Footnotes

Writing and editorial support were provided by Liqing Xiao and Jennifer Tyson of AlphaBioCom LLC, and funded by Neos Therapeutics Inc.

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