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A Linkage Study Between the GABAA β2 and GABAAγ2 Subunit Genes and Major Psychoses

Published online by Cambridge University Press:  07 November 2014

Alda M. Ambrósio ,
James L. Kennedy ,
Fabio Macciardi ,
Nicole King ,
Maria H. Azevedo ,
Catarina R. Oliveira  and
Carlos N. Pato
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Abstract

Background:

Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses.

Objective:

Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses.

Methods:

Thirty-two schizophrenic families and 25 bipolar families were tested for linkage.

Results:

Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAAβ2: NPL narrow=−0.450; NPL broad=−0.808; GABAA γ2: NPL narrow=0.177; NPL broad=−0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=−0.159; NPL broad=0.070).

Conclusion:

Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population.

Type
Original Research
Information
CNS Spectrums , Volume 10 , Issue 1 , January 2005 , pp. 57 - 61
Copyright
Copyright © Cambridge University Press 2005

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