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Metabolites: novel therapeutics or “me-too” drugs? Using desvenlafaxine as an example

  • Thomas L. Schwartz (a1)
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Abstract
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*Address for correspondence: Thomas L. Schwartz, Associate Professor, Director of Adult Clinical Services, Dept. of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA. (Email schwartt@upstate.edu)
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3. SH Preskorn . Understanding outliers on the usual dose response curve: venlafaxine as a way to phenotype patients in terms of their CYP 2D6 status and why it matters. J Psychiatr Pract. 2010; 16(1): 4649.

4. AL Nichols , K Focht , O Jiang , . Pharmacokinetics of venlafaxine extended release 75 mg and desvenlafaxine 50 mg in healthy CYP2D6 extensive and poor metabolizers: a randomized, open-label, two-period, parallel-group, crossover study. Clin Drug Investig. 2001; 31(3): 155167.

5. KW Lobello , SH Preskorn , CJ Guico-Pabia . CYP2D6 phenotype predicts antidepressant efficacy of venlafaxine. J Clin Psychiatry. 2010; 71(11): 14821487.

6. CJ Bachmeier , D Beaulieu-Abdelahad , NJ Ganey , . Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos. 2011; 32(4): 233244.

7. JH Lin . Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv Drug Deliv Rev. 2003; 55: 5381.

8. AI Nichols , KA Tourian , SY Tse , . Desvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin-norepinephrine reuptake inhibitor. Expert Opin Drug Metab Toxicol. 2010; 6(12): 15651574.

9. K Droll , K Bruce-Mensah , SV Otton , . Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians. Pharmacogenetics. 1998; 8(4): 325333.

10. I Ieiri , H Takane , K Otsubo . The MDR1 (ABCB1) gene polymorphism and its clinical implications. Clin Pharmacokinet. 2004; 43(9): 553576.

11. CJ Guico-Pabia , Q Jiang , PT Ninan , . Clinical outcomes following switch from venlafaxine ER to desvenlafaxine in nonresponders and responders. Curr Med Res Opin. 2011; 27(9): 18151826.

12. P Bech , P Boyer , JM Germain , . HAM-D17 and HAM-D6 sensitivity to change in relation to desvenlafaxine dose and baseline depression severity in major depressive disorder. Pharmacopsychiatry. 2010; 43(7): 271276.

13. T Norman . The new antidepressants—mechanisms of action. Aust Prescr. 1999; 22: 106108.

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CNS Spectrums
  • ISSN: 1092-8529
  • EISSN: 2165-6509
  • URL: /core/journals/cns-spectrums
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