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Overlapping neurobehavioral circuits in ADHD, obesity, and binge eating: evidence from neuroimaging research

  • Karen E. Seymour (a1), Shauna P. Reinblatt (a1), Leora Benson (a1) and Susan Carnell (a1)
Abstract

Attention-deficit/hyperactivity disorder (ADHD) and conditions involving excessive eating (eg, obesity, binge/loss of control eating) are increasingly prevalent within pediatric populations, and correlational and some longitudinal studies have suggested inter-relationships between these disorders. In addition, a number of common neural correlates are emerging across conditions, eg, functional abnormalities within circuits subserving reward processing and executive functioning. To explore this potential cross-condition overlap in neurobehavioral underpinnings, we selectively review relevant functional neuroimaging literature, specifically focusing on studies probing (i) reward processing, (ii) response inhibition, and (iii) emotional processing and regulation, and we outline 3 specific shared neurobehavioral circuits. Based on our review, we also identify gaps within the literature that would benefit from further research.

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Corresponding author
*Address for correspondence, Karen E. Seymour, PhD, Johns Hopkins University School of Medicine, Division of Child & Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, 550 N. Broadway, Baltimore, MD 21205, USA.(Email: kseymou2@jhmi.edu)
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