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Predictors of functional response and remission with desvenlafaxine 50 mg/d in patients with major depressive disorder

  • Claudio N. Soares (a1), Jean Endicott (a2), Matthieu Boucher (a3), Rana S. Fayyad (a4) and Christine J. Guico-Pabia (a5)...

The predictive value of early functional improvement for treatment success at week 8 was assessed in a pooled analysis in patients with major depressive disorder (MDD).


Data were pooled from 7 double-blind studies in adult patients with MDD randomly assigned to desvenlafaxine 50 mg/d or placebo. Four levels of treatment success were determined at week 8 for patients with baseline Sheehan Disability Scale (SDS) score > 12 (N = 2156): functional response (SDS ≤12 and ≥50% improvement in SDS), functional/depression response (SDS ≤12 and ≥50% improvement in both SDS and 17-item Hamilton Rating Scale for Depression [HAM-D17] score), functional remission (SDS < 7), and functional/depression remission (SDS < 7 and HAM-D17 ≤7). Week 2 improvement in SDS was evaluated as a predictor of later functional response/remission using receiver operating characteristic analysis. Odds ratios (ORs) of the predictability of improvement thresholds were computed from a logistic regression model.


The proportion of patients achieving each level of treatment success was significantly greater for patients treated with desvenlafaxine (40%, 32%, 23%, 15%, respectively) vs placebo (31%, 22%, 17%, 10%; all P ≤ 0.002). Early change in SDS was a highly significant predictor of functional response/remission (ORs, 0.958–0.970; all P < 0.0001).


Patients’ early functional response to desvenlafaxine 50 mg/d is predictive of treatment success.

Corresponding author
Address for correspondence: Claudio N. Soares, MD, PhD, FRCPC, Women's Health Concerns Clinic, 301 James St. South FB638, Hamilton, ON, Canada. (Email
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This study was sponsored by Pfizer. Medical writing support was provided by Kathleen Dorries, PhD, of Peloton Advantage and was funded by Pfizer.

Clinical Trial Registry Numbers: 332:, NCT00277823; 333:, NCT00300378; 335:, NCT00384033; 3359:, NCT00798707; 3362:, NCT00863798; 3364:, NCT01121484; 4415:, NCT00824291.

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CNS Spectrums
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