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Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

  • Bernardo Dell’Osso (a1) (a2), Beatrice Benatti (a1), Chiara Arici (a1), Carlotta Palazzo (a1), A. Carlo Altamura (a1), Eric Hollander (a3), Naomi Fineberg (a4), Dan J. Stein (a5), Humberto Nicolini (a6) (a7), Nuria Lanzagorta (a7), Donatella Marazziti (a8), Stefano Pallanti (a9), Michael van Ameringen (a10), Christine Lochner (a11), Oguz Karamustafalioglu (a12), Luchezar Hranov (a13), Martijn Figee (a14), Lynne Drummond (a15), Carolyn I. Rodriguez (a2), John Grant (a16), Damiaan Denys (a14), Jose M. Menchon (a17) and Joseph Zohar (a18)...
Abstract
Objective

Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCD patients.

Methods

A total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson’s chi-squared and t tests. Logistic regression was performed to assess the impact of the collected data on the SA variable.

Results

14.6% of our sample reported at least one SA during their lifetime. Patients with an SA had significantly higher rates of comorbid psychiatric disorders (60 vs. 17%, p<0.001; particularly tic disorder), medical disorders (51 vs. 15%, p<0.001), and previous hospitalizations (62 vs. 11%, p<0.001) than patients with no history of SA. With respect to geographical differences, European and South African patients showed significantly higher rates of SA history (40 and 39%, respectively) compared to North American and Middle-Eastern individuals (13 and 8%, respectively) (χ2=11.4, p<0.001). The logistic regression did not show any statistically significant predictor of SA among selected independent variables.

Conclusions

Our international study found a history of SA prevalence of ~15% in OCD patients, with higher rates of psychiatric and medical comorbidities and previous hospitalizations in patients with a previous SA. Along with potential geographical influences, the presence of the abovementioned features should recommend additional caution in the assessment of suicide risk in OCD patients.

Copyright
Corresponding author
*Address correspondence and reprint requests to: Bernardo Dell’Osso, Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’Granda, Ospedale Maggiore Policlinico–Milano, Via Francesco Sforza 35, 20122 Milano, Italy. (Email: bernardo.dellosso@unimi.it)
Footnotes
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This research was supported by the European College of Neuropsychopharmacology (ECNP) Research Networks Initiative.

Footnotes
References
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