1.Johannessen Landmark C, Larsson PG, Rytter E, Johannessen SI. Antiepileptic drugs in epilepsy and other disorders--a population-based study of prescriptions. Epilepsy Res. 2009; 87(1): 31–39.
2.Hayes J, Prah P, Nazareth I, etal. Prescribing trends in bipolar disorder: cohort study in the United Kingdom THIN primary care database 1995–2009. PLoS One. 2011; 6(12): e28725.
3.Barbui C, Conti V, Purgato M, etal. Use of antipsychotic drugs and mood stabilizers in women of childbearing age with schizophrenia and bipolar disorder: epidemiological survey. Epidemiol Psychiatr Sci. 2013; 22(4): 355–361.
4.Adedinsewo DA, Thurman DJ, Luo YH, etal. Valproate prescriptions for nonepilepsy disorders in reproductive-age women. Birth Defects Res A Clin Mol Teratol. 2013; 97(6): 403–408.
5.Gentile S. Prophylactic treatment of bipolar disorder in pregnancy and breastfeeding: focus on emerging mood stabilizers. Bipolar Disord. 2006; 8(3): 207–220.
6.Gentile S. Bipolar disorder and pregnancy: to treat or not to treat? BMJ. 2012; 345: e7367.
7.Vajda FJ, O'Brien TJ, Graham JE, Lander CM, Eadie MJ. Dose dependence of fetal malformations associated with valproate. Neurology. 2013; 81(11): 999–1003.
8.Meador KJ. Comment: valproate dose effects differ across congenital malformations. Neurology. 2013; 81(11): 1002.
9.Pennell PB, Klein AM, Browning N, etal. Differential effects of antiepileptic drugs on neonatal outcomes. Epilepsy Behav. 2012; 24(4): 449–456.
10.FDA Drug Safety Communication. Valproate anti-seizure products contraindicated for migraine prevention in pregnant women due to decreased IQ scores in exposed children. http://www.fda.gov/Drugs/DrugSafety/ucm350684.htm. Accessed: July 5, 2013.
11.Koch S, Titze K, Zimmermann RB, etal. Long-term epilepsy and neuropsychological consequences of maternal anticonvulsant treatment during pregnancy for school-age children and adolescents. Epilepsia. 1999; 40(9): 1237–1243.
13.Steinhausen HC, Losche G, Koch S, Helge H. The psychological development of children of epileptic parents. I. Study design and comparative findings. Acta Paediatr. 1994; 83(9): 955–960.
14.Losche G, Steinhausen HC, Koch S, Helge H. The psychological development of children of epileptic parents. II. The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors. Acta Paediatr. 1994; 83(9): 961–966.
15.Koch S, Jäger-Roman E, Lösche G, etal. Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome. Acta Paediatr. 1996; 84(6): 739–746.
16.Adab N, Jacoby D, Smith D, Chadwick D. Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry. 2001; 70(1): 15–21.
17.Dean CS, Hailey H, Moore SJ, etal. Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth. J Med Genet. 2002; 39(4): 251–259.
18.Gaily E, Kantola-Sorsa E, Hiilesmaa V, etal. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology. 2004; 362(1): 28–32.
19.Eriksson K, Viinikainen K, Monkkonen A, etal. Children exposed to valproate in utero—population based evaluation of risks and confounding factors for long-term neurocognitive development. Epilepsy Res. 2005; 65(3): 189–200.
20.Viinikainen K, Eriksson K, Monkkonen A, etal. The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children. Epilepsy Behav. 2006; 9(4): 636–640.
21.Thomas SV, Ajaykumar B, Sindhu K, etal. Motor and mental development of infants exposed to antiepileptic drugs in utero. Epilepsy Behav. 2008; 13(1): 229–236.
22.Meador KJ, Baker GA, Browning N, etal. for the NEAD Study Group. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med. 2009; 360(16): 1597–1605.
23.McVearry KM, Gaillard WD, VanMeter J, Meador KJ. A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy. Epilepsy Behav. 2009; 16(4): 609–616.
24.Cohen MJ, Meador KJ, Browning N, etal. Fetal antiepileptic drug exposure: motor, adaptive, and emotional/behavioral/functioning at age 3 years. Epilepsy Behav. 2011; 22(2): 240–246.
25.Meador KJ, Baker GA, Browning N, etal. for the NEAD Study Group. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years. Neurology. 2012; 78(16): 1207–1214.
26.Meador KJ, Baker GA, Browning N, etal. for the NEAD Study Group. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol. 2013; 12(3): 244–252.
27.Cohen MJ, Meador KJ, Browning N, etal, for the NEAD study group. Fetal antiepileptic drug exposure: adaptive and emotional/behavioral functioning at age 6 years. Epilepsy Behav. 2013; 29(2): 308–315.
28.Meador KJ, Baker GA, Browning N, etal, for the NEAD Study Group. Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age. Brain. 2011; 134(Pt 2): 396–404.
29.Adab N, Kini U, Vinten J, etal. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry. 2004; 75(11): 1575–1583.
30.Vinten J, Adab N, Kini U, etal, for the Liverpool and Manchester Neurodevelopment Study Group. Neuropsychological effects of exposure to anticonvulsant medication in utero. Neurology. 2005; 64(6): 949–954.
31.Vinten J, Bromley RL, Taylor J, etal, on behalf of the Liverpool and Manchester Neurodevelopment Group. The behavioral consequences of exposure to antiepileptic drugs in utero. Epilepsy Behav. 2009; 14(1): 197–201.
32.Bromley RL, Mawer G, Love J, etal, on behalf of the Liverpool and Manchester Neurodevelopment Group. Early cognitive development in children born to women with epilepsy: a prospective report. Epilepsia. 2010; 51(10): 2058–2065.
33.Shallcross R, Bromley RL, Irwin B, etal, on behalf of the Liverpool/Manchester Neurodevelopment Group and the UK Epilepsy and Pregnancy Register. Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology. 2011; 76(4): 383–389.
34.Bromley RL, Mawer G, Clayton-Smith J, Baker GA, on behalf of the Liverpool and Manchester Neurodevelopment Group. Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology. 2008; 71(28): 1923–1924.
35.Bromley RL, Mawer GE, Briggs M, etal, on Behalf of the Liverpool and Manchester Neurodevelopment Group.. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry. 2013; 84(6): 637–643.
36.Johnson CP, Myers SM. American Academy of Pediatrics Council on Children with Disabilities. Identification and evaluation of children with autistic spectrum disorders. Pediatrics. 2007; 120(5): 1183–1215.
37.Nadebaum C, Anderson V, Vajda F, etal. The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy. J Int Neuropsychol Soc. 2011; 17(1): 133–142.
38.Nadebaum C, Anderson V, Vajda F, etal. Language skills of school-aged children prenatally exposed to antiepileptic drugs. Neurology. 2011; 76(8): 719–726.
39.Cummings C, Stewart M, Stevenson M, Morrow J, Nelson J. Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine. Arch Dis Child. 2011; 96(7): 643–647.
40.Kantola-Sorsa E, Gaily E, Isoaho M, Korkman M. Neuropsychological outcomes in children of mothers with epilepsy. J Int Neuropsychol Soc. 2007; 13(4): 642–652.
41.Christensen J, Grønborg TK, Sørensen MJ, etal. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013; 309(16): 1696–1703.
42.Veiby G, Daltvei AK, Schjølberg S, etal. Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia. 2013; 54(8): 1462–1472.
43.Rosner B. Fundamentals of Biostatistics. Belmont, CA: Duxbury-Brooks/Cole; 2006.
44.Veiby G, Engelsen BA, Gilhus NE. Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy. JAMA Neurol. 2013; 70(11): 1367–1374.
45.Thomas JM, Benham AL, Gean M, etal. Practice parameters for the psychiatric assessment of infant and toddlers (0-36 months). American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry. 1997; 36(10 Suppl): S21–S36.
46.Meisels SJ, Provence S. Screening and Assessment: Guidelines for Identifying Young Disabled and Developmentally Vulnerable Children and Their Families. Washington, DC: Zero to Three/National Center for Clinical Infants Program; 1989.
47.Gentile S. SSRIs in pregnancy and lactation with emphasis on neurodevelopmental outcome. CNS Drugs. 2005; 19(7): 623–633.
48.Thapar A, Fowler T, Rice F, etal. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Am J Psychiatry. 2003; 160(11): 1985–1989.
49.Larsson HJ, Eaton WW, Madsen KK. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol. 2005; 161(10): 916–925.
50.Hultman CM, Sparén P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology. 2002; 13(4): 417–423.
51.Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet. 1991; 337(8746): 867–872.
52.Wright TL, Hoffman LH, Davies. Lithium teratogenicity. Lancet. 1970; 24; 2(7678): 876.
53.Pennell PB, Klein AM, Browning N, etal, for the NEAD Study Group. Differential effects of antiepileptic drugs on neonatal outcomes. Epilepsy Behav. 2012; 24(4): 449–456.
54.Fox AW, Diamond ML, Spiering EL. Migraine during pregnancy: options for therapy. CNS Drugs. 2005; 19(6): 465–481.
56.Holmes LB, Hernandez-Diaz S. Newer anticonvulsants: lamotrigine, topiramate and gabapentin. Birth Defects Res A Clin Mol Teratol. 2012; 94(8): 599–606.
58.Campbell E, Kennedy F, Irwin B, etal. Malformation risks of antiepileptic drug monotherapies in pregnancy. J Neurol Neurosurg Psychiatry. 2013; Nov; 84(11): e2.
59.Gentile S. Lithium in pregnancy: the need to treat, the duty to ensure safety. Exp Opin Drug Saf. 2012; 11(3): 425–437.
60.Vajda FJ, Graham J, Roten A, etal. Teratogenicity of the newer antiepileptic drugs—the Australian experience. J Clin Neurosci. 2012; 19(1): 57–59.
61.Gentile S. Antipsychotic therapy during early and late pregnancy: a systematic review. Schizophr Bull. 2010; 36(3): 518–544.
62.Kjaer D, Christensen J, Becha BH, etal. Preschool behavioral problems in children prenatally exposed to antiepileptic drugs—a follow-up study. Epilepsy Behav. 2013; 29(2): 407–411.
63.Boden R, Lundgren M, Brandt L, etal. Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study. BMJ. 2012; 345: e7085.
65.Frederick IO, Qiu C, Enquobahrie DA, etal. Lifetime prevalence and correlates of migraine among women in a Pacific Northwest pregnancy cohort study. Headache. In press. doi: 10.1111/head.12206.
66.Wright G, Patel M. Focal migraine and pregnancy. BMJ. 1986; 293(6561): 1557–1558.
67.MacGregor EA. Headache in pregnancy. Neurol Clin. 2012; 30(3): 835–866.