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Women's Mental Health During Pregnancy Influences Fetal and Infant Developmental and Health Outcomes

Published online by Cambridge University Press:  07 November 2014

Ilona S. Federenko  and
Pathik D. Wadhwa
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Abstract

Women's mental health during pregnancy has important implications not only for the well-being of the mother, but also for the development, health, and well-being of her unborn child. A growing body of empirical evidence from population-based studies suggests that two indicators of women's mental health during pregnancy—psychosocial stress and social support—may exert a significant influence on fetal development and infant birth outcomes, such as birth weight and length of gestation, even after controlling for the effects of established sociodemographic, obstetric, and behavioral risk factors. This paper describes the role of three major biological systems involved in the physiology of pregnancy and stress physiology: neuroendocrine, immune/inflammatory, and cardiovascular systems. These systems have been hypothesized to mediate the effects of maternal mental health on fetal developmental and health outcomes, and a central role has been proposed for placental corticotropin-releasing hormone in this process. However, not all women reporting high prenatal stress and/or low social support proceed to develop adverse birth outcomes, raising the question of the determinants of susceptibility/vulnerability in the context of high stress and/or low social support. In this context, the role of race/ethnicity and genetic predisposition are. discussed as two promising avenues of further investigation.

Type
Review Articles
Information
CNS Spectrums , Volume 9 , Issue 3 , March 2004 , pp. 198 - 206
Copyright
Copyright © Cambridge University Press 2004

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References

REFERENCES

1.Stowe, ZN, Calhoun, K, Ramsey, C, Sadek, N, Newport, J. Mood disorders during pregnancy and lactation: defining issues of exposure and treatment. CNS Spectr. 2001;6:150–166.CrossRefGoogle Scholar
2.Andersson, L, Sundström-Poromaa, I, Bixo, M, Wulff, M, Bondestam, K, Åström, M. Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol. 2003;189:148–154.CrossRefGoogle ScholarPubMed
3.Wadhwa, PD, Glynn, L, Hobel, CJ, et al.Behavioral perinatology: biobehavioral processes in human fetal development. Regul Pept. 2002;108:149–157.CrossRefGoogle ScholarPubMed
4.Copper, RL, Goldenberg, RL, Das, A, et al.The preterm prediction study: maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks' gestation. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol.. 1996;175:1286–1292.CrossRefGoogle ScholarPubMed
5.Dole, N, Savitz, DA, Hertz-Picciotto, I, Siega-Riz, AM, McMahon, MJ, Buekens, P. Maternal stress and preterm birth. Am J Epidemiol. 2003;157:14–24.CrossRefGoogle ScholarPubMed
6.Hedegaard, M, Henriksen, TB, Sabroe, S, Secher, NJ. Psychological distress in pregnancy and preterm delivery. BMJ. 1993;307:234–239.CrossRefGoogle ScholarPubMed
7.Misra, DP, O'Campo, P, Strobino, D. Testing a sociomedical model for preterm delivery. Paediatr Perimt Epidemiol. 2001;15:110–122.CrossRefGoogle ScholarPubMed
8.Nordentoft, M, Lou, HC, Hansen, D, et al.Intrauterine growth retardation and premature delivery: the influence of maternal smoking and psychosocial factors. Am J Public Health. 1996;86:347–354.CrossRefGoogle ScholarPubMed
9.Pritchard, CW, Teo, PY. Preterm birth, low birthweight and the stressfulness of the household role for pregnant women. Soc Sci Med. 1994;38:89–96.CrossRefGoogle ScholarPubMed
10.Axelrod, J, Reisine, TD. Stress hormones: their interaction and regulation. Science. 1984;224:452–459.CrossRefGoogle ScholarPubMed
11.Herbert, TB, Cohen, S. Stress and immunity in humans: a meta-analytic review. Psychosom Med. 1993;55:364–379.CrossRefGoogle ScholarPubMed
12.Chrousos, GP, Gold, PW. The concepts of stress and stress system disorders. JAMA. 1992;267:1244–1252.CrossRefGoogle ScholarPubMed
13.McEwen, BS, Stellar, E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993;153:2093–2101.CrossRefGoogle ScholarPubMed
14.Cosmi, EV, Luzi, G, Gori, F, Chiodi, A. Response of utero-placental fetal blood flow to stress situation and drugs. Eur J Obstet Gynecol Reprod Biol. 1990;36:239.CrossRefGoogle ScholarPubMed
15.Myers, RE. Maternal psychological stress and fetal asphyxia: a study in the monkey. Am J Obstet Gynecol. 1975;122:47–59.CrossRefGoogle ScholarPubMed
16.Shepherd, RW, Stanczyk, FZ, Bethea, CL, Novy, MJ. Fetal and maternal endocrine responses to reduced uteroplacental blood flow. J Clin Endocrinol Metab. 1992;75:301–307.Google ScholarPubMed
17.McLean, M, Bisits, A, Davies, J, Woods, R, Lowry, P, Smith, R. A placental clock controlling the length of human pregnancy. Nat Med. 1995;1:460–463.CrossRefGoogle ScholarPubMed
18.De Souza, EB. Corticotropin-releasing factor and interleukin-1 receptors in die brain-endocrine-immune axis. Role in stress response and infection. Ann N Y Acad Sci. 1993;697:9–27.CrossRefGoogle Scholar
19.Jemmott, JB 3rd, Locke, SE. Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: how much do we know? Psychol Bull. 1984;95:78–108.CrossRefGoogle ScholarPubMed
20.Garite, TJ. Premature rupture of the membranes. In: Creasy, RK, Resnik, R, eds. Maternal-Fetal Medicine; Principles and Practice. Philadelphia, Penn: W.B. Saunders & Co.; 1994;625–638.Google Scholar
21.Lockwood, CJ. Recent advances in elucidating the pathogenesis of preterm delivery, the detection of patients at risk, and preventative therapies. Curr Opin Obstet Gynecol. 1994;6:7–18.CrossRefGoogle ScholarPubMed
22.Hobel, C, Culhane, J. Role of psychosocial and nutritional stress on poor pregnancy outcome. J Nutr. 2003;133(5 suppl 2):1709S–1717S.CrossRefGoogle ScholarPubMed
23.Hannigan, JH, Armant, DR. Alcohol in pregnancy and neonatal outcome. Semin Neonatol. 2000;5:243–254.CrossRefGoogle ScholarPubMed
24.Higgins, S. Smoking in pregnancy. Curr Opin Obstet Gynecol. 2002;14:145–151.CrossRefGoogle ScholarPubMed
25.Bishai, R, Koren, G. Maternal and obstetric effects of prenatal drug exposure. Clin Perinotol. 1999;26:75–86, vii.CrossRefGoogle ScholarPubMed
26.Khan, IY, Lakasing, L, Poston, L, Nicolaides, KH. Fetal programming for adult disease: where next? J Matern Fetal Neonatal Med. 2003;13:292–299.CrossRefGoogle ScholarPubMed
27.Zuckerman, B, Bauchner, H, Parker, S, Cabral, H. Maternal depressive symptoms during pregnancy, and newborn irritability. J Dev Behav Pediatr. 1990;11:190–194.CrossRefGoogle ScholarPubMed
28.Pritchard, CW. Depression and smoking in pregnancy in Scotland. J Epidemiol Community Health. 1994;48:377–382.CrossRefGoogle ScholarPubMed
29.Pascoe, JM, Kokotailo, PK, Broekhuizen, FF. Correlates of multigravida women's binge drinking during pregnancy. A longitudinal study. Arch Pediatr Adolesc Med. 1995;149:1325–1329.CrossRefGoogle ScholarPubMed
30.McCormick, MC, Brooks-Gunn, J, Shorter, T, Holmes, JH, Wallace, CY, Heagarty, MC. Factors associated with smoking in low-income pregnant women: relationship to birth weight, stressful life events, social support, health behaviors and mental distress. J Clin Epidemiol. 1990;43:441–448.CrossRefGoogle ScholarPubMed
31.Bresnahan, K, Zuckerman, B, Cabral, H. Psychosocial correlates of drug and heavy alcohol use among pregnant women at risk for drug use. Obstet Gynecol. 1992;80:976–980.Google ScholarPubMed
32.Hoffman, S, Hatch, MC. Stress, social support and pregnancy outcome: a reassessment based on recent research. Paediatr Perinat Epidemiol. 1996;10:380–405.CrossRefGoogle ScholarPubMed
33.Dejin-Karlsson, E, Ostergren, PO. Psychosocial factors, lifestyle, and fetal growth: the added value of both pre- and post-natal assessments. Eur J Public Health. 2003;13:210–217.CrossRefGoogle ScholarPubMed
34.McEwen, BS. Protective and damaging effects of stress mediators. N Engl J Med. 1998;338:171–179.CrossRefGoogle ScholarPubMed
35.Yen, SSC. Endocrinology of pregnancy. In: Creasy, RK, Resnik, R, eds. Maternal-Fetal Medicine: Principles and Practice. Philadelphia, Penn: W.B. Saunders & Co.; 1994;382–412.Google Scholar
36.Smith, R, Mesiano, S, McGrath, S. Hormone trajectories leading to human birth. Regul Pept. 2002;108:159–164.CrossRefGoogle ScholarPubMed
37.Mesiano, S. Roles of Estrogen and Progesterone in Human Parturition. Newcastle, Australia: Karger; 2001.CrossRefGoogle ScholarPubMed
38.Grammatopoulos, DK, Hillhouse, EW. Role of corticotropin-releasing hormone in onset of labor. Lancet. 1999;354:1546–1549.CrossRefGoogle Scholar
39.Challis, JRG, Matthews, SG, Gibb, W, Lye, SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000;21:514–550.Google Scholar
40.Petraglia, F, Florio, P, Nappi, C, Genazzani, AR. Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms. Endocr Rev. 1996;17:156–186.Google ScholarPubMed
41.Majzoub, JA, Karalis, KP. Placental corticotropin-releasing hormone: function and regulation. Am J Obstet Gynecol. 1999;180(1 pt 3):S242–S246.CrossRefGoogle ScholarPubMed
42.Jaffe, RB. Role of human fetal adrenal gland in the initiation of parturition. In: Smith, R, ed. The Endocrinology of Parturition. Newcastle, Australia: Karger; 2001.Google Scholar
43.Smith, R. The timing of birth. Sci Am. 1999;280:68–75.CrossRefGoogle ScholarPubMed
44.Petraglia, F, Sawchenko, PE, Rivier, J, Vale, W. Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta. Nature. 1987;328:717–719.CrossRefGoogle ScholarPubMed
45.Petraglia, F, Sutton, S, Vale, W. Neurotransmitters and peptides modulate the release of immunoreactive corticotropin-releasing factor from cultured human placental cells. Am J Obstet Gynecol. 1989;160:247–251.CrossRefGoogle ScholarPubMed
46.Florio, P, Severi, FM, Ciarmela, P, Fiore, G, Calonaci, G, Merola, A, De Felice, C, Palumbo, M, Petraglia, F. Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family. Endocrine. 2002; 19(1): 91–102.CrossRefGoogle ScholarPubMed
47.Korebrits, C, Yu, DH, Ramirez, MM, Marinoni, E, Becking, AD, Challis, JR. Antenatal glucocorticoid administration increases corticotrophin-releasing hormone in maternal plasma. Br J Obstet Gynaecol. 1998;105:556–561.CrossRefGoogle ScholarPubMed
48.Smith, R, Mesiano, S, Chan, EC, Brown, S, Jaffe, RB. Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998;83:2916–2920.Google ScholarPubMed
49.Challis, JR, Matthews, SG, Van Meir, C, Ramirez, MM. Current topic: the placental corticotrophin-releasing hormone-adrenocorticotrophin axis. Placenta. 1995;16:481–502.CrossRefGoogle ScholarPubMed
50.Campbell, EA, Linton, EA, Wolfe, CD, Scraggs, PR, Jones, MT, Lowry, PJ. Plasma corticotropin-releasing hormone concentrations during pregnancy and parturition. J Clin Endocrinol Metab. 1987;64:1054–1059.CrossRefGoogle ScholarPubMed
51.Erickson, K, Thorsen, P, Chrousos, G, Grigoriadis, DE, Khongsaly, O, McGregor, J, Schulkin, J. Preterm birth: associated neuroendocrine, medical, and behavioral risk factors. J Clin Endocrinol Metab. 2001;86:2544–2552.Google ScholarPubMed
52.Hobel, CJ, Dunkel-Schetter, C, Roesch, SC, Castro, LC, Arora, CP. Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery. Am J Obstet Gynecol. 1999;180 (1 pt 3):S257–S263.CrossRefGoogle ScholarPubMed
53.Holzman, C, Jetton, J, Siler-Khodr, T, Fisher, R, Rip, T. Second trimester corticotropin-releasing hormone levels in relation to preterm delivery and ethnicity. Obstet Gynecol. 2001;97:657–663.Google ScholarPubMed
54.Kurki, T, Laatikainen, T, Salminen-Lappalainen, K, Ylikorkala, O. Maternal plasma corticotrophin-releasing hormone-elevated in preterm labor but unaffected by indomethacin or nylidrin. Br J Obsta Gynaecol. 1991;98:685–691.CrossRefGoogle ScholarPubMed
55.Petraglia, F, Aguzzoli, L, Florio, P, et al.Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery. Placenta. 1995;16:157–164.CrossRefGoogle ScholarPubMed
56.Wadhwa, PD, Porto, M, Garite, TJ, Chicz-DeMet A, Sandman, CA. Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy. Am J Obstet Gynecol. 1998;179:1079–1085.CrossRefGoogle ScholarPubMed
57.Warren, WB, Patrick, SL, Goland, RS. Elevated maternal plasma corticotropinreleasing hormone levels in pregnancies complicated by preterm labor. Am J Obstet Gynecol. 1992;166:1198–1204.CrossRefGoogle ScholarPubMed
58.Wolfe, CD, Patel, SP, Linton, EA, Campbell, EA, Anderson, J, Dornhorst, A, Lowry, PJ, Jones, MT. Plasma corticotrophin-releasing factor (CRF) in abnormal pregnancy. Br J Obstet Gynaecol. 1988;95:1003–1006.CrossRefGoogle ScholarPubMed
59.McGrath, S, McLean, M, Smith, D, Bisits, A, Giles, W, Smith, R. Maternal plasma corticotropin-releasing hormone trajectories vary depending on the cause of preterm delivery. Am J Obstet Gynecol. 2002;186:257–260.CrossRefGoogle ScholarPubMed
60.Wadhwa, PD, Sandman, CA, Chicz-DeMet, A, Porto, M. Placental CRH modulates maternal pituitary adrenal function in human pregnancy. Ann N Y Acad Sci. 1997;814:276–281.CrossRefGoogle ScholarPubMed
61.Chan, EC, Smith, R, Lewin, T, et al.Plasma corticotropin-releasing hormone, beta-endorphin and cortisol inter-relationships during human pregnancy. Acta Endocrinol (Copenh). 1993;128:339–344.Google ScholarPubMed
62.Goland, RS, Conwell, IM, Warren, WB, Wardlaw, SL. Placental corticotropin-releasing hormone and pituitary-adrenal function during pregnancy. Neuroendocrinology. 1992;56:742–749.CrossRefGoogle ScholarPubMed
63.Sasaki, A, Shinkawa, O, Yoshinaga, K. Placental corticotropin-releasing hormone may be a stimulator of maternal pituitary adrenocorticotropic hormone secretion in humans. J Clin Invest. 1989;84:1997–2001.CrossRefGoogle ScholarPubMed
64.Wadhwa, PD, Dunkel-Schetter, C, Chicz-DeMet, A, Porto, M, Sandman, CA. Prenatal psychosocial factors and the neuroendocrine axis in human pregnancy. Psychosom Med. 1996;58:432–446.CrossRefGoogle ScholarPubMed
65.Petraglia, F, Hatch, MC, Lapinski, R, et al.Lack of effect of psychosocial stress on maternal corticotropin-releasing factor and catecholamine levels at 28 weeks' gestation. J Soc Gynecol Investig. 2001;8:83–88.CrossRefGoogle ScholarPubMed
66.Lockwood, CJ, Kuczynski, E. Markers of risk for preterm delivery. J Perinat Med. 1999;27:5–20.CrossRefGoogle ScholarPubMed
67.Spina, V, Aleandri, V, Pacchiarotti, A, Salvi, M. [Immune tolerance in pregnancy. Maternal-fetal interactions]. Minerva Gincol. 1998;50:533–537. Italian.Google ScholarPubMed
68.Strelkauskas, AJ, Davies, IJ, Dray, S. Longitudinal studies showing alterations in the levels and functional response of T and B lymphocytes in human pregnancy. Clin Exp Immunol. 1978;32:531–539.Google Scholar
69.Gehrz, RC, Christianson, WR, Linner, KM, Conroy, MM, McCue, SA, Balfour, HH Jr. A longitudinal analysis of lymphocyte proliferative responses to mitogens and antigens during human pregnancy. Am J Obstet Gynecol. 1981;140:665–670.CrossRefGoogle ScholarPubMed
70.Lin, H, Mosmann, TR, Guilbert, L, Tuntipopipat, S, Wegmann, TG. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol. 1993;151:4562–4573.CrossRefGoogle ScholarPubMed
71.Piccinni, MP, Romagnani, S. Regulation of fetal allograft survival by a hormonecontrolled Th1- and Th2-type cytokines. Immunol Res. 1996;15:141–150.CrossRefGoogle ScholarPubMed
72.Shaarawy, M, Nagui, AR. Enhanced expression of cytokines may play a fundamental role in the mechanisms of immunologically mediated recurrent spontaneous abortion. Acta Obstet Gynecol Scand. 1997;76:205–211.CrossRefGoogle ScholarPubMed
73.Szereday, L, Varga, P, Szekeres-Bartho, J. Cytokine production by lymphocytes in pregnancy. Am J Retrod Immunol. 1997;38:418–422.CrossRefGoogle ScholarPubMed
74.Oleszczuk, J, Darmochwal-Kolarz, D, Leszczynska-Gorzelak, B, Rolinski, J. Alterations in the immune system of patients with imminent preterm labor. Gynecol Obstet Invest. 2000;49:110–113.CrossRefGoogle Scholar
75.Hillier, SL, Witkin, SS, Krohn, MA, Watts, DH, Kiviat, NB, Eschenbach, DA. The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection. Obsta Gynecol. 1993;81:941–948.Google ScholarPubMed
76.Romero, R, Gomez, R, Ghezzi, F, Yoon, BH, Mazor, M, Edwin, SS, Berry, SM. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol. 1998;179:186–193.CrossRefGoogle ScholarPubMed
77.Romero, R, Mazor, M, Munoz, H, Gomez, R, Galasso, M, Sherer, DM. The pretern labor syndrome. Ann N Y Acad Sci. 1994;34:414–429.CrossRefGoogle Scholar
78.Herrera, JA, Alvarado, JP, Martínez, JE. The psychosocial environment and the cellular immunity in the pregnant patient. Stress Med. 1988;4:49–57.CrossRefGoogle Scholar
79.Culhane, JF, Rauh, V, McCollum, KF, Elo, IT, Hogan, V. Exposure to chronic stress and ethnic differences in rates of bacterial vaginosis among pregnant women. Am J Obstet Gynecol. 2002;187:1272–1276.CrossRefGoogle ScholarPubMed
80.Monga, M, Creasy, RK. Cardiovascular and renal adaptation to pregnancy. In: Creasy, RK, Resnik, R, eds. Maternal-fetal Medicine: Principles and Practice. Philadelphia, Penn: W.B. Saunders & Co.; 1994;758–767.Google Scholar
81.Meis, PJ, Goldenberg, RL, Mercer, BM, et al.The preterm prediction study: risk factors for indicated preterm births. Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development. Am J Obstet Gynecol. 1998;178:562–567.CrossRefGoogle ScholarPubMed
82.Rozanski, A, Blumenthal, JA, Kaplan, J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation. 1999;99:2192–2217.CrossRefGoogle ScholarPubMed
83.Esch, T, Stefano, GB, Fricchione, GL, Benson, H. Stress in cardiovascular diseases. Med Sci Monit. 2002;8:RA93-RA101.Google ScholarPubMed
84.Curtis, BM, O'Keefe, JH Jr. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clin Proc. 2002;77:45–54.CrossRefGoogle ScholarPubMed
85.Sharpley, CF. Psychosocial stress-induced heart rate reactivity and atherogenesis: cause or correlation? J Behav Med. 1998;21:411–432.CrossRefGoogle ScholarPubMed
86.Yeung, AC, Vekshtein, VI, Krantz, DS, et al. The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress. N Engl J Med. 1991;325:1551–1556.CrossRefGoogle ScholarPubMed
87.Jiang, W, Babyak, M, Krantz, DS, et al. Mental stress-induced myocardial ischemia and cardiac events. JAMA. 1996;275:1651–1656.CrossRefGoogle ScholarPubMed
88.Chang, Q, Natelson, BH, Ottenweller, JE, Conway, RS. Stress triggers different pathophysiological mechanisms in younger and older cardiomyopathic hamsters. Cardiovasc Res. 1995;30:985–991.CrossRefGoogle ScholarPubMed
89.McCubbin, JA, Lawson, EJ, Cox, S, Sherman, JJ, Norton, JA, Read, JA. Prenatal maternal blood pressure response to stress predicts birth weight and gestational age: a preliminary study. Am J Obsta Gynecol. 1996; 175:706–712.CrossRefGoogle ScholarPubMed
90.Huneke, B, Ude, C. [Uteroplacental and fetal arterial Ultrasound Doppler Flow Velocity measurements in unselected pregnancies as a screening test at 32 to 34 gestational weeks]. Z Geburtshilfe Neonatol. 2002;206:57–64. German.Google ScholarPubMed
91.Sjostrom, K, Valentin, L, Thelin, T, Marsal, K. Maternal anxiety in late pregnancy: effect on fetal movements and fetal heart rate. Early Hum Dev. 2002;67:87–100.CrossRefGoogle ScholarPubMed
92.Teixeira, JM, Fisk, NM, Glover, V. Association between maternal anxiety in pregnancy and increased uterine artery resistance index: cohort based study. BMJ. 1999;318:153–157.CrossRefGoogle ScholarPubMed
93.Jeske, W, Soszynski, P, Lukaszewicz, E, et al. Enhancement of plasma corticotropinreleasing hormone in pregnancy-induced hypertension. Acta Endocrinol (Copenh). 1990;122:711–714.Google ScholarPubMed
94.Perkins, AV, Linton, EA, Eben, F, Simpson, J, Wolfe, CD, Redman, CW. Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies. Br J Obsta Gynoecol. 1995; 102:118–122.CrossRefGoogle ScholarPubMed
95.Warren, WB, Gurewitsch, ED, Goland, RS. Corticotropin-releasing hormone and pituitary-adrenal hormones in pregnancies complicated by chronic hypertension. Am J Obstet Gynecol. 1995;172:661–666.CrossRefGoogle ScholarPubMed
96.Giles, WB, McLean, M, Davies, JJ, Smith, R. Abnormal umbilical artery Doppler waveforms and cord blood corticotropin-releasing hormone. Obstet Gynecol. 1996;87:107–111.CrossRefGoogle ScholarPubMed
97.Wadhwa, PD. Prenatal stress and life-span development. In: Friedman, HS, ed. Encyclopedia of Mental Health. San Diego, Calif: Academic Press; 1998;265–280.Google Scholar
98.Wadhwa, PD, Sandman, CA, Garite, TJ. The neurobiology of stress in human pregnancy: implications for prematurity and development of the fetal central nervous system. Prog Brain Res. 2001;133:131–142.CrossRefGoogle ScholarPubMed
99.Matthews, SG, Owen, D, Banjanin, S, Andrews, MH. Glucocorticoids, hypothalamo-pituitary-adrenal (HPA) development, and life after birth. Endocr Rev. 2002;28:707–718.Google ScholarPubMed
100.Matthews, SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endcrinol Metab. 2002;13:373–380.CrossRefGoogle ScholarPubMed
101.Welberg, LA, Seckl, JR. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol. 2001;13:113–128.CrossRefGoogle ScholarPubMed
102.Cabral, H, Fried, LE, Levenson, S, Amaro, H, Zuckerman, B. Foreign-born and US-born black women: differences in health behaviors and birth outcomes. Am J Public Health. 1990;80:70–72.CrossRefGoogle ScholarPubMed
103.Collins, JW Jr, Hammond, NA. Relation of maternal race to the risk of preterm, non-low birth weight infants: a population study. Am J Epidemiol. 1996;143:333–337.CrossRefGoogle Scholar
104.Guyer, B, Hoyert, DL, Martin, JA, Ventura, SJ, MacDorman, MF, Strobino, DM. Annual summary of vital statistics—1998. Pediatrics. 1999;104:1229–1246.CrossRefGoogle ScholarPubMed
105.Schoendorf, KC, Hogue, CJ, Kleinman, JC, Rowley, D. Mortality among infants of black as compared with white college-educated parents. N Engl J Med. 1992;326:1522–1526.CrossRefGoogle Scholar
106.Hogue, CJ, Hoffman, S, Hatch, MC. Stress and preterm delivery: a conceptual framework. Paediatr Perinat Epidemiol. 2001; 15(suppl 2):30–40.CrossRefGoogle ScholarPubMed
107.Rich-Edwards, J, Krieger, N, Majzoub, J, Zierler, S, Lieberman, E, Gillman, M. Maternal experiences of racism and violence as predictors of preterm birth: rationale and study design. Paediatr Perinat Epidemiol 2001; 15(suppl 2):124–135.CrossRefGoogle ScholarPubMed
108.Siler-Khodr, TM, Forthman, G, Khodr, C, Matyszczyk, S, Khodr, Z, Khodr, G. Maternal serum corticotropin-releasing hormone at midgestation in Hispanic and white women. Obstet Gynecol. 2003;101:557–564.Google ScholarPubMed
109.Wüst, S, van Rossum, EFC, Federenko, IS, Koper, JW, Kumsta, R, Hellhammer, DH. Common polymorphisms of the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Eniocrinol Metab. 2004; 89 (2): 565–573.CrossRefGoogle ScholarPubMed
110.Baerwald, CGO, Mok, C, Fife, MS, et al. Distribution of corticotropin-releasing hormone promoter polymorphism in different ethnic groups: evidence for natural selection in human populations. Immunogenetics. 1999;49:894–899.CrossRefGoogle ScholarPubMed