1Higgins, A and Lees, P (1984). The acute inflammatory process, arachidonic acid metabolism and the mode of action of anti-inflammatory drugs – a review. Equine Veterinary Journal 16: 163–175.
2Han, J and Ulevitch, R (2005). Limiting inflammatory responses during activation of innate immunity – a review. Nature Immunology 6: 1198–1205.
3Cannon, J and Kluger, M (1983). Endogenous pyrogen activity in human plasma after exercise. Science 220: 617–619.
4Moldoveanu, A, Shephard, R and Shek, P (2001). The cytokine response to physical activity and training (Review). Sports Medicine 31: 115–144.
5Brenner, I, Natale, V, Vasiliou, P, Moldoveanu, A, Shek, P and Shephard, R (1999). Impact of three different types of exercise on components of the inflammatory response. European Journal of Applied Physiology 80: 452–460.
6Shek, P, Sabiston, B, Buguet, A and Radomski, M (1995). Strenuous exercise and immunological changes: a multiple-time-point analysis of leukocyte subsets, CD4/CD8 ratio, immunoglobulin production and NK cell response. International Journal of Sports Medicine 15: 466–474.
7Cannon, J (2000). Inflammatory cytokines in nonpathological states. News in Physiological Sciences 15: 298–303.
8Moncada, S and Higgs, A (1993). The l-arginine–nitric oxide pathway. New England Journal of Medicine 329: 2002–2012.
9Sureda, A, Tauler, P, Aguilo, A, Fuentespina, E, Cordova, A, Tur, J and Pons, A (2006). Blood cell NO synthesis in response to exercise. Nitric Oxide 15: 5–12.
10Bird, J, Wells, T, Platt, D and Bayliss, M (1997). IL-1 beta induces the degradation of equine articular cartilage by a mechanism that is not mediated by nitric oxide. Biochemical and Biophysical Research Communications 238: 81–85.
11Kim, D, Taylor, H, Moore, R, Paulsen, D and Cho, D (2003). Articular chondrocyte apoptosis in equine osteoarthritis. The Veterinary Journal 166: 52–57.
12Murrell, G, Jang, D and Williams, R (1995). Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochemical and Biophysical Research Communications 206: 15–21.
13Farrell, A, Blake, D, Parlmer, R and Moncada, S (1992). Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Annals of the Rheumatic Diseases 51: 1219–1222.
14Johnston, S and Fox, S (1997). Mechanisms of action of anti-inflammatory medication used for the treatment of osteoarthritis. Journal of the American Veterinary Medical Association 210: 1486–1492.
15Dimock, A, Siciliano, P and McIlwraith, C (2000). Evidence supporting an increased presence of reactive oxygen species in the diseased equine joint. Equine Veterinary Journal 32: 439–443.
16Van den Boom, R, van de lest, C, Bull, S, Brama, P, van Weeren, P and Barneveld, A (2005). Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints. Equine Veterinary Journal 37: 250–256.
17Auer, D, Ng, J, Hrdlicka, J and Seawright, A (1989). The elimination of injected superoxide dismutase from synovial fluid of the horse. Australian Veterinary Journal 66: 117–119.
18Henneke, D, Potter, G, Kreider, J and Yeates, B (1983). Relationship between condition score, physical measurement, and body fat percentage in mares. Equine Veterinary Journal 15: 371–372.
19Westervelt, R, Stouffer, H, Hintz, H and Schryver, H (1976). Estimating fatness in horses and ponies. Journal of Animal Science 43: 781–785.
20McKeever, KH and Malinowski, K (1997). Exercise capacity in young and old mares. American Journal of Veterinary Research 58: 1468–1472.
21Williams, C and Carlucci, S (2006). Oral vitamin E supplementation and oxidative stress, vitamin and antioxidant status in intensely exercising horses. Equine Veterinary Journal Supplement 36: 617–621.
22Graham-Thiers, P, Kronfeld, D, Kline, K, Sklan, D and Harris, P (2003). Dietary protein and fat effects on protein status in Arabian horses during interval training and repeated sprints. Journal of Equine Veterinary Science 23: 554–559.
23Wilson, J, Kronfeld, D, Gay, L, Williams, J, Wilson, T and Lindinger, M (1998). Sarcoplasmic reticulum responses to repeated sprints are affected by conditioning of horses. Journal of Animal Science 76: 3065–3071.
24Vick, M, Adams, A, Murphy, B, Sessions, D, Horohov, D, Cook, R, Shelton, B and Fitzgerald, B (2007). Relationships among inflammatory cytokines, obesity, and insulin sensitivity in the horse. Journal of Animal Science 85: 1144–1155.
25Ainsworth, D, Appleton, J, Eicker, S, Luce, R, Flaminio, M and Antczak, F (2003). The effect of strenuous exercise on mRNA concentrations of interleukin-12, interferon-gamma and interleukin-4 in equine pulmonary and peripheral blood mononuclear cells. Veterinary. Immunology and Immunopathology 91: 61–71.
26Colahan, P, Kollias-Baker, C, Leutenegger, C and Jones, J (2002). Does training affect mRNA transcription for cytokine production in circulating leucocytes? Equine Veterinary Journal Supplement 34: 154–158.
27Ostrowski, K, Rohde, T, Asp, S, Schjerling, P and Pedersen, B (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology 515: 287–291.
28Cross, A (1996). Novel approaches to the treatment of sepsis: lessons learned and future directions. Shock 6: 71–74.
29Rhind, S, Shek, P, Shinkai, S and Shephard, R (1996). Effects of moderate endurance exercise and training on in vitro lymphocyte proliferation, interleukin-2, production, and IL-2 receptor expression. European Journal of Applied Physiology 74: 348–360.
30Peake, J, Suzuki, K, Hordern, M, Wilson, G, Nosaka, K and Coombes, J (2005). Plasma cytokine changes in relation to exercise intensity and muscle damage. European Journal of Applied Physiology 95: 514–521.
31Flynn, M, McFarlin, B and Markofski, M (2007). The anti-inflammatory actions of exercise training. American Journal of Lifestyle Medicine 1: 220–235.
32Moyna, N, Acker, G, Fulton, J, Weber, K, Goss, F, Roberson, R, Tollerud, D and Rabin, B (1996). Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females. International Journal of Sports Medicine 17: 585–591.
33Pavlov, V and Tracey, K (2004). Review – neural regulators of innate immune responses and inflammation. Cellular and Molecular Life Sciences 61: 2322–2331.
34Gannon, G, Rhind, S, Suzuki, M, Shek, P and Shaphard, R (1997). Circulating levels of peripheral blood leucocytes and cytokines following competitive cycling. Canadian Journal of Applied Physiology 22: 133–147.
35Niess, A, Passek Lorenz, I, Dickhuth, H, Northoff, H and Fehrenback, E (1999). Expression of the antioxidant stress protein heme oxygenase-I (HO-I) I human leukocytes. Acute and adaptational response to endurance exercise. Journal of Free Radicals and Biology in Medicine 26: 184–192.
36Bruunsgaard, H, Galbo, H, Halkjaer-Kristensen, J, Johansen, T, MacLean, D and Pedersen, B (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. Journal of Physiology 499: 833–841.
37Northoff, H, Enkel, S and Weinstock, C (1995). Exercise, injury and immune function. Exercise Immunology Reviews 1: 1–25.
38Mucci, P, Durand, F, Lebel, B, Bousquet, J and Prefaut, C (2000). Interleukins 1-beta, -8, and histamine increases in highly trained, exercising athletes. Medicine and Science in Sports and Exercise 32: 1094–1100.
39Suzuki, S, Nakaji, S, Yamada, M, Totsuka, M, Sato, K and Sugawara, K (2002). Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exercise Immunology Review 8: 6–48.
40Suzuki, K, Nakaji, S, Yamada, M, Liu, Q, Kurakake, S, Okamura, N, Kumae, T, Umeda, T and Sugawara, K (2003). Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Medicine and Science in Sports and Exercise 35: 348–355.
41Sprenger, H, Jacobs, C, Nain, M, Gressner, A, Prinz, H, Wesemann, W and Gemsa, D (1992). Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clinical Immunology and Immunopathology 63: 188–195.
42Petersen, A and Pedersen, B (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology 98: 1154–1162.
43Ostrowski, K, Hermann, C, Bangash, A, Schjerling, P, Nielsen, J and Pedersen, B (1998). A trauma-like elevation of plasma cytokines in humans in response to treadmill running. Journal of Physiology 513: 889–894.
44Pedersen, B (2000). Special feature for the Olympics: effects of exercise on the immune system: exercise and cytokines. Immunology and Cell Biology 78: 532–535.
45MacIntyre, D, Sorichter, S, Mair, J, Berg, A and McKenzie, D (2001). Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. European Journal of Applied Physiology 84: 180–186.
46Haahr, P, Pedersen, B, Fomsgaard, A, Tvede, N, Diamant, M, Klarlund, K, Halkjaer-Kristensen, J and Bendtzen, K (1991). Effect of physical exercise on in vitro production of interleukin 1, interleukin 6, tumour necrosis factor-alpha, interleukin 2 and interferon-gamma. International Journal of Sports Medicine 12: 223–227.
47Kindig, C, Gallatin, L, Erickson, H, Fedde, M and Poole, D (2000). Cardiorespiratory impact of the nitric oxide synthase inhibitor l-NAME in the exercising horse. Respiratory Physiology 120: 151–156.
48Manohar, M, Goetz, T and Hassan, A (2006). Nitric oxide synthase inhibition in Thoroughbred horses augments O2 extraction at rest and submaximal exercise, but not during short-term maximal exercise. Equine Veterinary Journal Supplement 36: 481–486.
49Mills, P, Marlin, D, Scott, C and Smith, N (1997). Nitric oxide and thermoregulation during exercise in the horse. Journal of Applied Physiology 82: 1035–1039.
50Cai, H and Harrison, D (2000). Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circulation Research 87: 841–844.
51Tauler, P, Auuilo, A, Cases, N, Sureda, A, Gimenez, F, Villa, G, Cordova, A and Biescas, A (2002). Acute phase immune response to exercise coexists with decreased neutrophil antioxidant enzyme defenses. Free Radical Research 36: 1101–1107.
52Suzuki, S, Totsuke, M, Nakaji, S, Yamada, M, Kudoh, S, Liu, Q, Sugawara, K, Yamaya, K and Sato, K (1999). Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. Journal of Applied Physiology 87: 1360–1367.
53Clarkson, P and Thompson, H (2000). Antioxidants: what role do they play in physical activity and health? The American Journal of Clinical Nutrition Supplement 72: 637S–646S.
54Jung, O, Marklund, S, Geiger, H, Pedrazzini, T, Busse, R and Brandes, R (2003). Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability. Circulation Research 93: 622–629.
55Jonsson, L, Rees, D, Edlund, T and Marklund, S (2002). Nitric oxide and blood pressure in mice lacking extracellular-superoxide dismutase. Free Radical Research 36: 755–758.
56Van den boom, R, Brama, P, Kiers, G, DeGroot, J, Barneveld, A and van Weeren, R (2004). The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and tumour necrosis factor alpha activities in normal equine joints. Equine Veterinary Journal 36: 155–159.
57Gronhahl, A and Dolvik, N (1993). Heritability estimations of osteochondrosis in the tibiotarsal joint and of bony fragments in the palmar/plantar portion of the metacarpo- and metatarsophalangeal joints of horses. Journal of the American Veterinary Medical Association 203: 101–104.
58Dutto, D, Hoyt, D, Cogger, E and Wickler, S (2004). Ground reaction forces in horses trotting up an incline and on the level over a range of speeds. Journal of Experimental Biology 207: 3507–3514.
59Fenton, J, Chlebek-Brown, K, Peters, T, Caron, J and Orth, M (2000). Glucosamine HCl reduces equine articular cartilage degradation in explant culture. Osteoarthritis and Cartilage 8: 258–265.
60Tung, J, Fenton, J, Arnold, C, Alexander, L, Yuzbasiyan-Gurkan, V, Venta, P, Peters, T, Orth, M, Richardson, D and Caron, J (2002). Recombinant equine interleukin-1 beta induces putative mediators of articular cartilage degradation in equine chondrocytes. Canadian Journal of Veterinary Research 66: 19–25.
61Stefanovic-Racic, M, Meyers, K, Meschter, C, Coffey, J, Hoffman, R and Evans, C (1994). N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis and Rheumatism 37: 1062–1069.
62Stefanovic-Racic, M, Meyers, K, Meschter, C, Coffey, J, Hoffman, R and Evans, C (1995). Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. Journal of Rheumatology 22: 1922–1928.
63Wiseman, M, Henson, F, Lee, D and Bader, D (2003). Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface. Equine Veterinary Journal 35: 451–456.