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  • Developmental Medicine & Child Neurology, Volume 48, Issue 9
  • September 2006, pp. 770-772

Recurrent optic neuritis associated with Chlamydia pneumoniae infection of the central nervous system

  • Daniela Pohl (a1), Kevin Rostasy (a1), Jens Gieffers (a2), Matthias Maass (a3) and Folker Hanefeld (a1)
  • DOI:
  • Published online: 14 August 2006

It has been suggested that Chlamydia pneumoniae (C. pneumoniae) is involved in the pathogenesis of diverse diseases of the central nervous system (CNS), including multiple sclerosis. We report the case of a 12-year-old male with isolated recurrent optic neuritis and an associated CNS infection with C. pneumoniae. The patient presented with three attacks of optic neuritis within 5 months. A positive polymerase chain reaction for C. pneumoniae in the cerebrospinal fluid led to the diagnosis of a CNS infection with C. pneumoniae. After treatment with the antibiotic rifampicin, he experienced no further attacks during the follow-up period of 6 years. These findings suggest the possibility of a C. pneumoniae infection as a contributing factor or even causative event for the development of optic neuritis.

Corresponding author
Department of Paediatrics and Paediatric Neurology, Georg-August-Universität Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany. E-mail:
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Developmental Medicine and Child Neurology
  • ISSN: 0012-1622
  • EISSN: 1469-8749
  • URL: /core/journals/developmental-medicine-and-child-neurology
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