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Detrimental Health Effects of Benzene Exposure in Adults After a Flaring Disaster at the BP Refinery Plant in Texas City

  • Mark A. D’Andrea (a1) and G. Kesava Reddy (a1)

Abstract

Objective

To examine the adverse effects of benzene exposure in adults from a prolonged flaring disaster at the BP refinery in Texas City, Texas.

Methods

Adults aged 18 years and older who had been exposed and unexposed to benzene were included. We reviewed medical charts and compared measures of white blood cells (WBCs), platelets, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), aspartate amino transferase (AST), and alanine amino transferase (ALT) in exposed and unexposed adults.

Results

Records from 2213 adults (benzene exposed, n=1826; unexposed, n=387) were reviewed. Benzene-exposed subjects had significantly higher WBC counts (7.9±2.3 vs 6.8±1.6×103 per µL, P=0.0000) and platelet counts (270.8±60.9 vs 242.5±53.7×103 per µL, P=0.0000) than did the unexposed subjects. Serum creatinine levels were also significantly higher in the exposed group than in the unexposed group (1.0±0.2 vs 0.8±0.2 mg/dL, P=0.000). Serum levels of ALP were significantly higher in the exposed subjects than in the unexposed subjects (82.1±15.6 vs 71.8±8.2 IU/L, P=0.000). Similarly, benzene-exposed subjects had significantly higher levels of AST (26.2±6.4 vs 19.7±5.3 IU/L, P=0.000) and ALT (30.6±10.8 vs 20.9±9.6 IU/L, P=0.000) than in those unexposed to benzene.

Conclusion

Benzene exposure resulted in significant alterations in hematologic and liver profiles in adults. (Disaster Med Public Health Preparedness. 2016;10:233–239)

Copyright

Corresponding author

Correspondence and reprint requests to G. Kesava Reddy, PhD, MHA, University Cancer and Diagnostic Centers, 12811 Beamer Road, Houston, TX 77089 (e-mail: kreddy_usa@yahoo.com).

References

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1. Rothman, N, Smith, MT, Hayes, RB, et al. An epidemiologic study of early biologic effects of benzene in Chinese workers. Environ Health Perspect. 1996;104(suppl 6):1365-1370. http://dx.doi.org/10.1289/ehp.961041365.
2. Wallace, L. Environmental exposure to benzene: an update. Environ Health Perspect. 1996;104(suppl 6):1129-1136. http://dx.doi.org/10.1289/ehp.961041129.
3. Smith, MT. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health. 2010;31(1):133-148. http://dx.doi.org/10.1146/annurev.publhealth.012809.103646.
4. Snyder, R, Hedli, CC. An overview of benzene metabolism. Environ Health Perspect. 1996;104(suppl 6):1165-1171. http://dx.doi.org/10.1289/ehp.961041165.
5. Khalade, A, Jaakkola, MS, Pukkala, E, et al. Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis. Environ Health. 2010;9(1):31. http://dx.doi.org/10.1186/1476-069X-9-31.
6. Costantini, AS, Benvenuti, A, Vineis, P, et al. Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: evidence from the Italian Multicenter Case-Control Study. Am J Ind Med. 2008;51(11):803-811. http://dx.doi.org/10.1002/ajim.20592.
7. Snyder, R. Overview of the toxicology of benzene. J Toxicol Environ Health A. 2000;61(5-6):339-346. http://dx.doi.org/10.1080/00984100050166334.
8. Marchetti, F, Eskenazi, B, Weldon, RH, et al. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect. 2012;120(2):229-234. http://dx.doi.org/10.1289/ehp.1103921.
9. Avis, SP, Hutton, CJ. Acute benzene poisoning: a report of three fatalities. J Forensic Sci. 1993;38(3):599-602. http://dx.doi.org/10.1520/JFS13444J.
10. Winek, CL, Collom, WD. Benzene and toluene fatalities. J Occup Med. 1971;13:259-261.
11. Dundarz, MR, Turkbay, T, Akay, C, et al. Antioxidant enzymes and lipid peroxidation in adolescents with inhalant abuse. Turk J Pediatr. 2003;45:43-45.
12. Dere, E, Ari, F. Effect of Benzene on liver functions in rats (Rattus norvegicus). Environ Monit Assess. 2009;154(1-4):23-27. http://dx.doi.org/10.1007/s10661-008-0374-7.
13. Kotseva, K, Popov, T. Study of the cardiovascular effects of occupational exposure to organic solvents. Int Arch Occup Environ Health. 1998;71(suppl):S87-S91.
14. Baslo, A, Aksoy, M. Neurological abnormalities in chronic benzene poisoning. A study of six patients with aplastic anemia and two with preleukemia. Environ Res. 1982;27(2):457-465. http://dx.doi.org/10.1016/0013-9351(82)90100-1.
15. Mandiracioglu, A, Akgur, S, Kocabiyik, N, et al. Evaluation of neuropsychological symptoms and exposure to benzene, toluene and xylene among two different furniture worker groups in Izmir. Toxicol Ind Health. 2011;27(9):802-809. http://dx.doi.org/10.1177/0748233711399309.
16. ATSDR. Public Health Statement: Benzene. CAS#: 71-43-2. Agency for Toxic Substances and Disease Registry. http://www.atsdr.cdc.gov/ToxProfiles/tp3-c1-b.pdf. Published August 2007. Accessed June 2014.
17. Whysner, J, Vijayaraj Reddy, M, Ross, PM, et al. Genotoxicity of benzene and its metabolites. Mutat Res. 2004;566(2):99-130. http://dx.doi.org/10.1016/S1383-5742(03)00053-X.
18. Goldstein, BD. Benzene toxicity: a critical evaluation: hematotoxicity in humans. J Toxicol Environ Health Suppl . 1977;2:69-105.
19. Kim, S, Vermeulen, R, Waidyanatha, S, et al. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev. 2006;15(11):2246-2252. http://dx.doi.org/10.1158/1055-9965.EPI-06-0262.
20. Evans L. BP’s 40-Day Emissions Event. http://www.propublica.org/documents/item/bps-40-day-emissions-event. Published June 4, 2010. Accessed June 2014.
22. Evans, L. Texas Commission on Environmental Quality Investigation Report. Emissions Event (Incident No. 138052) Review on British Petroleum products, North America (Investigation No. 824714). 2010.
23. D’Andrea, MA, Reddy, GK. Adverse health effects of benzene exposure among children following a flaring incident at the British Petroleum refinery in Texas City. Clin Pediatr (Phila). 2015 Aug 11 [Epub ahead of print].
24. D’Andrea, MA, Reddy, GK. Hematological and hepatic alterations in nonsmoking residents exposed to benzene following a flaring incident at the British petroleum plant in Texas City. Environ Health. 2014;13(1):115. http://dx.doi.org/10.1186/1476-069X-13-115.
25. D’Andrea, MA, Reddy, GK. Health effects of benzene exposure among children following a flaring incident at the British Petroleum Refinery in Texas City. Pediatr Hematol Oncol. 2014;31(1):1-10. http://dx.doi.org/10.3109/08880018.2013.831511.
26. D’Andrea, MA, Singh, O, Reddy, GK. Health consequences of involuntary exposure to benzene following a flaring incident at British Petroleum refinery in Texas City. Am J Disaster Med . 2013;8:169-179. http://dx.doi.org/10.5055/ajdm.2013.0124.
27. Vlaanderen, J, Lan, Q, Kromhout, H, et al. Occupational benzene exposure and the risk of chronic myeloid leukemia: a meta-analysis of cohort studies incorporating study quality dimensions. Am J Ind Med. 2012;55(9):779-785. http://dx.doi.org/10.1002/ajim.22087.
28. McHale, CM, Zhang, L, Smith, MT. Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis. 2012;33(2):240-252. http://dx.doi.org/10.1093/carcin/bgr297.
29. Nishikawa, T, Izumo, K, Miyahara, E, et al. Benzene induces cytotoxicity without metabolic activation. J Occup Health. 2011;53(2):84-92. http://dx.doi.org/10.1539/joh.10-002-OA.
30. Liu, C-S, Tsai, J-H, Kuo, S-W. Comparison of complete blood counts and urinary benzene metabolites after exposure to benzene. Mid Taiwan J Med. 2000;5:235-242.
31. Ray, MR, Roychoudhury, S, Mukherjee, S, et al. Occupational benzene exposure from vehicular sources in India and its effect on hematology, lymphocyte subsets and platelet P-selectin expression. Toxicol Ind Health. 2007;23(3):167-175. http://dx.doi.org/10.1177/0748233707080907.
32. McHale, CM, Zhang, L, Lan, Q, et al. Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect. 2010;119(5):628-634. http://dx.doi.org/10.1289/ehp.1002546.
33. Avogbe, PH, Ayi-Fanou, L, Cachon, B, et al. Hematological changes among Beninese motor-bike taxi drivers exposed to benzene by urban air pollution. Afr J Environ Sci Technol. 2011;5:464-472.
34. Ceresa, C, Grazioli, C, Monteverde, A. On the behavior of thromboelastograms in rice-field leptospirosis [in Italian]. Minerva Med. 1960;51:3544-3552.
35. Aksoy, M, Dincol, K, Akgun, T, et al. Haematological effects of chronic benzene poisoning in 217 workers. Br J Ind Med. 1971;28:296-302.
36. Al-Helaly, LA, Ahmed, TY. Antioxidants and some biochemical parameters in workers exposed to petroleum station pollutants in Mosul City, Iraq. Int Res J Environ Sci. 2014;3:31-37.
37. Innerfield, F. Enzymes in Clinical Chemistry . New York, NY: McGraw Hill Publications; 1960.
38. Chang, WJ, Joe, KT, Park, HY, et al. The relationship of liver function tests to mixed exposure to lead and organic solvents. Ann Occup Environ Med. 2013;25(1):5. http://dx.doi.org/10.1186/2052-4374-25-5.
39. Mohammadi, S, Mehrparvar, A, Labbafinejad, Y, et al. The effect of exposure to a mixture of organic solvents on liver enzymes in an auto manufacturing plant. J Public Health. 2010;18(6):553-557. http://dx.doi.org/10.1007/s10389-010-0340-z.
40. Perez, CA, Bosia, JD, Cantore, MS, et al. Gastroenterol Hepatol. 2006;29:334-337. http://dx.doi.org/10.1157/13089716.
41. Tomei, F, Giuntoli, P, Biagi, M, et al. Liver damage among shoe repairers. Am J Ind Med. 1999;36(5):541-547. http://dx.doi.org/10.1002/(SICI)1097-0274(199911)36:5<541::AID-AJIM6>3.0.CO;2-4.
42. Fernández-D’Pool, J, Oroño-Osorio, A. Liver function of workers occupationally exposed to mixed organic solvents in a petrochemical. Invest Clin. 2001;42:87-106.
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