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Contributions from scientific research to the risk assessment of GMOs. Lessons learned from a symposium held in Brussels, Belgium, 21–22 October 2010

Published online by Cambridge University Press:  19 August 2011


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Review article
© ISBR, EDP Sciences, 2011


Albajes, R, Lumbierres, B, Pons, X (2009) Responsiveness of arthropod herbivores and their natural enemies to modified weed management in corn. Environ. Entomol. 38: 944954 Google ScholarPubMed
Barros, E, Lezar, S, Anttonen, MJ, van Dijk, JP, Röhlig, RM, Kok, EJ, Engel, KH (2010) Comparison of two GM maize varieties with a near-isogenic non-GM variety using transcriptomics, proteomics and metabolomics. Plant Biotechnol. J. 8: 436451 Google ScholarPubMed
Batista, R, Saibo, N, Lourenço, T, Oliveira, MM (2008) Microarray analyses reveal that plant mutagenesis may induce more transcriptomic changes than transgene insertion. Proc. Natl. Acad. Sci. USA 105: 36403645 Google ScholarPubMed
Bockstael, O, Chtarto, A, Wakkinen, J, Yang, X, Melas, C, Levivier, M, Brotchi, J, Tenenbaum, L (2008) Differential transgene expression profiles in rat brain, using rAAV2/1 vectors with tetracycline-inducible and cytomegalovirus promoters. Hum. Gene Ther. 19: 12931305 Google ScholarPubMed
Brandon, EF, Hermsen, HP, van Eijkeren, JC, Tiesjema, B (2010) Effect of administration route on the biodistribution and shedding of replication-deficient AAV2: a qualitative modeling approach. Curr. Gene Ther. 10: 91106 Google Scholar
Davies, HV, Shepherd, LV, Stewart, D, Frank, T, Röhlig, RM, Engel, KH (2010) Metabolome variability in crop plant species –when, where, how much and so what? Regul. Toxicol. Pharmacol. 58: S54S61 Google Scholar
Di Castri F (1992) L’écologie en temps réel. In Theys J, Kalaora B, eds, La terre outragée. Les experts sont formels ! Autrement, Paris
Dirks RHG, Van Dun CMP, Reinink K, inventors (2003) Reverse Breeding, World Intellectual Property Organization WO/2003/017753
Dirks, R, van Dun, K, de Snoo, CB, van den Berg, M, Lelivelt, CL, Voermans, W, Woudenberg, L, de Wit, JP, Reinink, K, Schut, JW, van der Zeeuw, E, Vogelaar, A, Freymark, G, Gutteling, EW, Keppel, MN, van Drongelen, P, Kieny, M, Ellul, P, Touraev, A, Ma, H, de Jong, H, Wijnker, E (2009) Reverse breeding: a novel breeding approach based on engineered meiosis. Plant Biotechnol. J. 7: 837845 Google ScholarPubMed
Duque, S, Joussemet, B, Riviere, C, Marais, T, Dubreil, L, Douar, AM, Fyfe, J, Moullier, P, Colle, MA, Barkats, M (2009) Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons. Mol. Ther. 17: 11871196 Google ScholarPubMed
EC (2001) Council Directive 2001/18/EC of 12 March 2001 on the deliberate release into the environment of genetically modified organisms and repealing Council Directive 90/220/EEC. Official Journal of the European Union L106: 1–38
EC (2009) Directive 2009/41/EC of the European Parliament and of the Council of 6 May 2009 on the contained use of genetically modified micro-organisms. Official Journal of the European Union L 125: 75–97
EFSA (2010) Guidance on the environmental risk assessment of genetically modified plants. EFSA Journal 8: 1879
Frank, T, Nörenberg, S, Engel, KH (2009) Metabolite profiling of two novel low phytic acid (lpa) soybean mutants. J. Agric. Food Chem. 57: 64086416 Google ScholarPubMed
Hadaczek, P, Forsayeth, J, Mirek, H, Munson, K, Bringas, J, Pivirotto, P, McBride, JL, Davidson, BL, Bankiewicz, KS (2009) Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum. Gene Ther. 20: 225237 Google ScholarPubMed
Henderson, IR, Jacoben, SE (2007) Epigenetic inheritance in plants. Nature 447: 418-424 Google ScholarPubMed
Johannes, F, Porcher, E, Teixeira, FK, Saliba-Colombani, V, Simon, M (2009) Assessing the impact of transgenerational epigenetic variation on complex traits. PLoS Genet. 5: e1000530 Google ScholarPubMed
Kogel, KH, Voll, LM, Schäfer, P, Jansen, C, Wu, Y, Langen, G, Imani, J, Hofmann, J, Schmiedl, A, Sonnewald, S, von Wettstein, D, Cook, RJ, Sonnewald, U (2010) Transcriptome and metabolome profiling of field-grown transgenic barley lack induced differences but show cultivar-specific variances. Proc. Natl. Acad. Sci. USA 107: 61986203 Google ScholarPubMed
Nap J-P, van Kessel AG (2006) Epigenetics in context, COGEM literature report 2006-05.
NIH (1976) Guidelines for Research Involving Recombinant DNA Molecules. National Institutes of Health, Donald S. Fredrickson papers.
OECD (1986) Recombinant DNA safety considerations, Paris.
Perry, JN, Ter Braak, CJ, Dixon, PM, Duan, JJ, Hails, RS, Huesken, A, Lavielle, M, Marvier, M, Scardi, M, Schmidt, K, Tothmeresz, B, Schaarschmidt, F, van der Voet, H (2009) Statistical aspects of environmental risk assessment of GM plants for effects on non-target organisms. Environ. Biosafety Res. 8: 6578 Google ScholarPubMed
Perry, JN, Devos, Y, Arpaia, S, Bartsch, D, Gathmann, A, Hails, RS, Kiss, J, Lheureux, K, Manachini, B, Mestdagh, S, Neemann, G, Ortego, F, Schiemann, J, Sweet, JB (2010) A mathematical model of exposure of non-target Lepidoptera to Bt-maize pollen expressing Cry1Ab within Europe. Proc. Biol. Sci. 277: 14171425 Google ScholarPubMed
Rauschen, S, Eckert, J, Schaarschmidt, F, Schuphan, I, Gathmann, A (2008) An evaluation of methods for assessing the impacts of Bt-maize MON810 cultivation and pyrethroid insecticide use on Auchenorrhyncha (Planthoppers and Leafhoppers). Agric. For. Entomol. 10: 331-339 Google Scholar
Rauschen, S, Schultheis, E, Pagel-Wieder, S, Schuphan, I, Eber, S (2009) Impact of Bt-corn MON88017 in comparison to three conventional lines on Trigonotylus caelestialium (Kirkaldy) (Heteroptera: Miridae) field densities. Transgenic Research 18: 203214 Google ScholarPubMed
Rauschen, S, Schaarschmidt, F, Gathmann, A (2010) Occurrence and field densities of Coleoptera in the maize herb layer: implications for Environmental Risk Assessment of genetically modified Bt-maize. Transgenic Res. 19: 727744 Google ScholarPubMed
Raybould, A (2006) Problem formulation and hypothesis testing for environmental risk assessments of genetically modified crops. Environ. Biosafety Res. 5: 119125 Google ScholarPubMed
Raybould, A (2007) Ecological and ecotoxicological methods for assessing the environmental risks of transgenic crops. Plant Sci. 173: 589-602 Google Scholar
Reinders, J, Wulff-Brande, BH, Mirouze, M, Mari-Ordonez, A, Dapp, M, Razhan, W, Bucher, E, Theiler, G, Paskowski, J (2009) Compromised stability of DNA methylation and transposon immobilization in mosaic Arabidopsis epigenomes. Genes Dev. 8: 939-950 Google Scholar
Richards, EJ (2006) Inherited epigenetic variation – revisiting soft inheritance. Nature Rev. Genet. 7: 395-401 Google ScholarPubMed
Röhlig, RM, Engel, KH (2010) Influence of the input system (conventional versus organic farming) on metabolite profiles of maize (Zea mays) kernels. J. Agric. Food Chem. 58: 30223030 Google ScholarPubMed
Romeis, J, Bartsch, D, Bigler, F, Candolfi, MP, Gielkens, MM, Hartley, SE, Hellmich, RL, Huesing, JE, Jepson, PC, Layton, R, Quemada, H, Raybould, A, Rose, RI, Schiemann, J, Sears, MK, Shelton, AM, Sweet, J, Vaituzis, Z, Wolt, JD (2008) Assessment of risk of insect-resistant transgenic crops to nontarget arthropods. Nat. Biotechnol. 26: 203208 Google ScholarPubMed
Samulski, RJ, Berns, KI, Tan, M, Muzyczka, N (1982) Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc. Natl. Acad. Sci. USA 79: 20772081 Google ScholarPubMed
SCBD (2000) Cartagena Protocol on Biosafety to the Convention on Biological Diversity: text and annexes, Secretariat of the Convention on Biological Diversity, Montreal
Steidler, L, Hans, W, Schotte, L, Neirynck, S, Obermeier, F, Falk, W, Fiers, W, Remaut, E (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289: 13521355 Google ScholarPubMed
Steidler, L, Neirynck, S, Huyghebaert, N, Snoeck, V, Vermeire, A, Goddeeris, B, Cox, E, Remon, JP, Remaut, E (2003) Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10. Nat. Biotechnol. 21: 785789 Google ScholarPubMed
Tenenbaum, L, Jurysta, F, Stathopoulos, A, Puschban, Z, Melas, C, Hermens, WT, Verhaagen, J, Pichon, B, Velu, T, Levivier, M (2000) Tropism of AAV-2 vectors for neurons of the globus pallidus. Neuroreport 11: 22772283 Google ScholarPubMed
Tiesjema, B, Hermsen, HP, van Eijkeren, JC, Brandon, EF (2010) Effect of administration route on the biodistribution and shedding of replication-deficient HAdV-5: a qualitative modelling approach. Curr. Gene Ther. 10: 107127 Google ScholarPubMed
van Dijk, JP, Leifert, C, Barros, E, Kok, EJ (2010) Gene expression profiling for food safety assessment: examples in potato and maize. Regul. Toxicol. Pharmacol. 58: S21S25 Google Scholar
Wolt, JD, Keese, P, Raybould, A, Fitzpatrick, JW, Burachik, M, Gray, A, Olin, SS, Schiemann, J, Sears, M, Wu, F (2010) Problem formulation in the environmental risk assessment for genetically modified plants. Transgenic Res. 19: 425436 Google ScholarPubMed