Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-06-14T05:24:37.791Z Has data issue: false hasContentIssue false

The administration of vitamin C in a large institution and its effect on general health and resistance to infection

Published online by Cambridge University Press:  15 May 2009

A. J. Glazebrook
Affiliation:
From the Departments of Clinical Medicine and Bacteriology, University of Edinburgh
Scott Thomson
Affiliation:
From the Departments of Clinical Medicine and Bacteriology, University of Edinburgh
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The vitamin C in the dietary of an institution was largely destroyed by the methods of cooking and distribution.

2. Some 50 mg. of ascorbic acid per head per day were required to be added to the diet to produce an optimum excretion level.

3. Large doses of ascorbic acid were given to a group of adolescents in the institution over a period of several months. A record was kept of the incidences of infectious diseases in this treated group and in the remainder (controls). The following conclusions were reached:

(a) The incidences of common cold and tonsillitis were the same in the two groups.

(b) The average duration of illness due to the common cold was the same in the two groups.

(c) The duration of illness of tonsillitis was longer in the control group than in the test group.

(d) Cases of rheumatic fever and pneumonia occurred in the control group but no case of either disease occurred in the test group.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1942

References

REFERENCES

Abbasy, M. A., & Harris, L. J., (1937). Lancet, 2, 1429.Google Scholar
Abbasy, M. A., Harris, L. J., & Ellman, P., (1937). Lancet, 2, 181.CrossRefGoogle Scholar
Abbasy, M. A., Harris, L. J., & Hill, N. J., (1937). Lancet, 2, 177.CrossRefGoogle Scholar
Abbasy, M. A., Harris, L. J., Ray, S. N., & Marrack, J. R., (1935). Lancet, 2, 1399.CrossRefGoogle Scholar
Abbasy, M. A., Hill, N. J., & Harris, L. J., (1936). Lancet, 2, 1413.CrossRefGoogle Scholar
Albrecht, E., (1938). Med. Klin. 34, 972.Google Scholar
Bakhsh, I., & Rabbani, M., (1939). Indian med. Gaz. 74, 274.Google Scholar
Bamberger, P., & Wendt, L., (1935). Klin. Wschr. 14, 846.CrossRefGoogle Scholar
Bamberger, P., & Zell, W., (1936). Z. Kinderheilk. 58, 307.Google Scholar
Birkhaug, K. E., (1939). Acta tuberc. scand. 13, 45.Google Scholar
Bloch, C. E., (1931). Amer. J. Dis. Child. 42, 263.CrossRefGoogle Scholar
Bonnholtzer, E., (1937). Dtsch. med. Wschr. 26, 1001.CrossRefGoogle Scholar
Bourne, G., (1938). Brit. med. J. 1, 560.CrossRefGoogle Scholar
Crandon, J. H., Lund, C. C., & Dill, D. B., (1940). New Engl. J. Med. 223, 353.CrossRefGoogle Scholar
Crawford, W., & Broadley, H., (1938). The Peoples Food. London: Heinemann.Google Scholar
Dieckhoff, J., & Schuler, K., (1938). Klin. Wschr. 17, 936.CrossRefGoogle Scholar
Erwin, G. S., Weight, R., & Doherty, C. J., (1940). Brit. med. J. 1, 688.CrossRefGoogle Scholar
Farmer, C. J., & Abt, A. F., (1935). Proc. Soc. exp. Biol., N.Y., 32, 1625.CrossRefGoogle Scholar
Fox, F. W., (1941). Brit. med. J. 1, 311.CrossRefGoogle Scholar
Fox, F. W., Dangerfield, L. F., Gottlich, S. F., & Jokl, E., (1940). Brit. med. J. 2, 143.CrossRefGoogle Scholar
Funck, C., (1931). The Vitamins. London.Google Scholar
Gairdner, D., (1938). Brit. med. J. 2, 742.CrossRefGoogle Scholar
Gander, J., & Neiderberger, W., (1936). Munch, med. Wschr. 83, 1386.Google Scholar
Gothlin, G. F., (1937). Lancet, 2, 703.CrossRefGoogle Scholar
Grant, A. H., (1926). J. infect. Dis. 39, 502.CrossRefGoogle Scholar
Grant, A. H., (1930). Amer. Rev. Tuberc. 21, 115.Google Scholar
Groth-Peterson, I. B., & Groth-Peterson, E., (1939). Nordisk. Med. 2, 1565.Google Scholar
Gunzel, W., & Kroehnert, G., (1937). Fortschr. Therap. 13, 460.Google Scholar
Hadfield, G., (1938). Communication to Pathological Society of Great Britain and Ireland.Google Scholar
Hagmann, E. A., (1937). J. Pediat. 11, 480.CrossRefGoogle Scholar
Ham, A. W., & Elliott, H. C., (1936). Amer. J. Anat. 58, 127.Google Scholar
Hamburger, R., & Goldschmidt, L., (19221923). Jb. Kinderheilk. 100, 210.Google Scholar
Harde, E., Rothstein, I. A., & Ratish, H. D., (1935). Proc. soc. exp. Biol., N.Y., 32, 1088.CrossRefGoogle Scholar
Harris, L. J., (1937). Brit. med. J. 1, 774.CrossRefGoogle Scholar
Harris, L. J., & Abbasy, M. A., (1937). Lancet. 2, 1429.CrossRefGoogle Scholar
Harris, L. J., Abbasy, M. A., & Yudkin, J., (1936). Lancet, 1, 1488.CrossRefGoogle Scholar
Harris, L. J., & Ray, S. N., (1935). Lancet, 1, 71.CrossRefGoogle Scholar
Harris, L. J., Ray, S. N., & Ward, A., (1933). Biochem. J. 27, 2011.CrossRefGoogle Scholar
Harrison, R. J., Mourane, A. E., & Wormall, A., (1938). St Bart's Hosp. J. 08, p. 224.Google Scholar
Hasselbach, F., (1936a). Dtsch. med. Wschr. 62, 924.CrossRefGoogle Scholar
Hasselbach, P., (1936b). Z. Tuberc. 75, 336.Google Scholar
Heise, F. H., & Martin, G. J., (1936). Proc. soc. exp. Biol., N.Y., 34, 642.CrossRefGoogle Scholar
Hess, A. F., (1917). J. Amer. med. Ass. 68, 235.CrossRefGoogle Scholar
Hess, A. F., (1920). Scurvy, Past and Present. London and Philadelphia.Google Scholar
Hess, A. F., (1923). System of Pediatrics. Philadelphia.Google Scholar
Hess, A. F., & Benjamin, H. R., (1934). Proc. Soc. exp. Biol., N.Y., 31, 855.CrossRefGoogle Scholar
Hochwald, A., (1937). Dtsch. med. Wschr. 63, 182.CrossRefGoogle Scholar
Hurford, J. V., (1938). Lancet, 1, 498.Google Scholar
Jennings, G. H., & Glazebrook, A. J., (1938). Brit. med. J. 2, 784.CrossRefGoogle Scholar
Johnson, S. W., & Zilva, S. S., (1934). Biochem. J. 28, 1393.CrossRefGoogle Scholar
Kellie, A. E., & Zilva, S. S., (1939). Biochem. J. 33, 153.CrossRefGoogle Scholar
Kendall, A. I., & Chinn, H., (1938). J. infect. Dis. 62, 330.CrossRefGoogle Scholar
Lind, W., (1772). Scurvy in Hampshire. London.Google Scholar
Mackay, H. M. M., (1934). Lancet, 2, 1462.CrossRefGoogle Scholar
Mirsky, I. A., Swadesh, S., & Soskin, S., (1935). Proc. Soc. exp. Biol., N.Y., 32, 1130.CrossRefGoogle Scholar
Mouriquand, G., & Edel, V., (1940). Bull. Acad. med. Paris, 123, 8.Google Scholar
Ormerod, M. J., & Unkauf, B., (1937). Canad. med. Ass. J. 37, 134.Google Scholar
Orr, J., (1936). Food, Health and Income. London.Google Scholar
Otani, T., (1936). Klin. Wschr. 51, 1884.CrossRefGoogle Scholar
Park, E. A., Guild, H. G., Jackson, D., & Bond, M., (1935). Arch. Dis. Child. 10, 265.CrossRefGoogle Scholar
Parsons, L. G., (1938). Lancet, 1, 65.CrossRefGoogle Scholar
Pemberton, J., (1940). Brit. med. J. 2, 217.CrossRefGoogle Scholar
Portnoy, B., & Wilkinson, J. F., (1938). Brit. med. J. 1, 554.CrossRefGoogle Scholar
Radford, M., de Savitsch, E. C., & Sweeney, H. C., (1937). Amer. Rev. Tuberc. 35, 784.Google Scholar
Rinehart, J. F., (1935). Ann. intern. Med. 9, 586.CrossRefGoogle Scholar
Rinehart, J. F., Greenberg, L. D., & Baker, F., (1936). Proc. soc. exp. Biol., N.Y., 35, 347.CrossRefGoogle Scholar
Rinehart, J. F., Greenberg, L. D., Olney, M. B., & Choy, F., (1938). Arch, intern. Med. 61, 552.CrossRefGoogle Scholar
Rinehart, J. F., & Mettier, S. R., (1933). Amer. J. Path. (Proc.), 9, 952.Google Scholar
Rinehart, J. F., & Mettier, S. R., (1934). Amer. J. Path. (Proc.), 10, 61.Google Scholar
Robertson, E. C., (1934). Medicine, 13, 123.CrossRefGoogle Scholar
Roff, F. S., & Glazebrook, A. J., (1939). J. Boy. nav. med. Senv. 25, 340.CrossRefGoogle Scholar
Roff, F. S., & Glazebrook, A. J., (1940). Brit. dent. J. 68, 135.Google Scholar
Schmidt-Weyland, P., & Koltzsch, W., (1928). Z. Hyg. InfektKr. 108, 199.CrossRefGoogle Scholar
Sennewald, K., (1938). Forschr. Therap. 14, 139.Google Scholar
Smith, S. L., (1938). J. Amer. med. Ass. 111, 1753.CrossRefGoogle Scholar
Stewart, C. P., Learmonth, J. R., & Pollock, J. A., (1941). Lancet, 1, 818.CrossRefGoogle Scholar
Szent-Gyorgyi, A., (1938). Pr. méid. 46, 995.Google Scholar
Szirmal, F., (1940). Dtsch. Arch. Klin. Med. 185, 434.Google Scholar
Thomson, S., & Glazebrook, A. J., (1942). J. Hyg., Camb., 41, 570.Google Scholar
Vogl, A., (1937). Munch, med. Wschr. 84, 1569.Google Scholar
Warns, E. H. J., (1938). Ned. Tij. Geneeskunde, 82, 393.Google Scholar
Werkman, C. H., Nelson, V. E., & Fulmer, E. I., (1924). J. Infect. Dis. 34, 447.CrossRefGoogle Scholar
Wolbach, S. B., (1936). J. Amer. med. Ass. 108, 7.CrossRefGoogle Scholar
Wolbach, S. B., & Howe, P. R., (1926). Arch. path. lab. Med. 1, 1.Google Scholar
Wright, I. S., Lilienfield, A., & Maclenathen, E., (1937). Arch, intern. Med. 60, 264.CrossRefGoogle Scholar
Zilva, S. S., (1938). Lancet, 1, 1411.Google Scholar