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Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis

Published online by Cambridge University Press:  30 March 2005

F. G. A. VERSTEEGH
Affiliation:
Department of Pediatrics, Groene Hart Hospital, Gouda, The Netherlands
P. L. J. M. MERTENS
Affiliation:
Municipal Health Department, Rotterdam, The Netherlands
H. E. DE MELKER
Affiliation:
National Institute of Public Health and the Environment, Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, Bilthoven, The Netherlands
J. J. ROORD
Affiliation:
Department of Pediatrics, Free University Medical Centre, Amsterdam, The Netherlands
J. F. P. SCHELLEKENS
Affiliation:
National Institute of Public Health and the Environment, Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, Bilthoven, The Netherlands
P. F. M. TEUNIS
Affiliation:
National Institute of Public Health and the Environment, Diagnostic Laboratory of Infectious Diseases and Perinatal Screening, Bilthoven, The Netherlands
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Abstract

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To investigate the possible dependence on age of the rate of decline of IgG antibodies to pertussis toxin (IgG-PT) after natural infection with Bordetella pertussis we measured IgG-PT in follow-up sera of 121 patients (age 0–94 years) obtained after 123 episodes of B. pertussis infection. For analysis we applied a dynamic model for the inactivation of B. pertussis by the immune system. There were no significant differences in rise, peak and decline of IgG-PT between different age groups, although there was a tendency for a more rapid increase, a higher peak and a faster decline with increasing age. The IgG-PT cut-off of 100 U/ml for serodiagnosis of pertussis appeared valid in all age groups. A decline of IgG-PT to <10 U/ml was associated with increased risk of re-infection with B. pertussis.

Type
Research Article
Copyright
2005 Cambridge University Press
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Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis
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