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Alterations in the Endogenous Enteric Bacterial Flora and Microbic Permeability of the Intestinal Wall in Relation to the Nutritional and Meteorological Changes

Published online by Cambridge University Press:  15 May 2009

Lloyd Arnold
Lloyd Arnold
Affiliation:
(From the Department of Bacteriology and Pathology, University of Illinois, College of Medicine, and Illinois State Department of Public Health, Chicago, Illinois.)
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There are certain demonstrable changes that take place within the gastrointestinal tract during the process of adaptation to external stimuli. The body as a whole reacts in this adjustment to a changing environment. We have presented our evidence and indicated some instances where these gastrointestinal changes can be considered significant from an epidemiological and preventive medicine standpoint.

The loss of the self-disinfecting power, changes in acid-base equilibrium, and other demonstrable alterations within the lumen of the alimentary tract are only a part of the changes taking place in the organism during the process of adaptation to external environmental changes. If certain diseases are associated with a disturbance of the equilibrium between the parasites and the host, then it naturally follows that we must have more information upon the biological mechanism of the host in regard to its changes in susceptibility and resistance to the parasitic environment. Our present knowledge of bacteriology throws little light upon this epidemiological question. It has been the aim of the author to study the mechanism by which the organism adapts itself to certain environmental changes. We have avoided using pharmacological and other artificial agents that would produce body changes, but have restricted ourselves to simple alterations in diet, external temperature and similar mild or natural environmental factors, and followed the mechanism of adaptation to these physiological stimuli.

The loss of the power of a body-covering layer, to destroy bacteria in contact with it, must increase the hazards of invasion of this body surface by bacteria. We have shown that a sudden change in the intra-intestinal acid-base equilibrium leads to an inhibition of the mucosa to destroy bacteria within its lumen and is accompanied at times by the appearance of viable bacteria in the thoracic duct lymph stream.

If an organism does not adapt itself to its meteorological environment, it is more susceptible to its parasitic environment. The same is true of the nutritional environmental factors. Disturbances due to lack of adaptation to climatic changes can in part be offset by altering the diet. The weather and food factors cannot be separated and one can influence the other.

Changes in climate are beneficial to the well-being of the population living in the temperate zones where meteorological conditions are ever changing as compared to the steady cold in the arctic or constant heat as in the tropics. Changes in food are also beneficial. A high protein meal is stimulating. In the tropics where the skin is in a state of over-stimulation due to the high external temperature and humidity the ingestion of an alcoholic beverage to stimulate the splanchnic system before a meal is beneficial. Acidifying an infant's food in hot weather is a common practice. Many such instances could be cited. It seems to be of advantage to an organism to be in a changing environment. The tonus of our physiological systems is not static or fixed, but is ever changing. The more delicate the index used to measure functional changes, the more frequently are such changes observed. These alterations in environment must not exceed the power of the organism to adapt itself to these changes.

Type
Research Article
Information
Journal of Hygiene , Volume 29 , Issue 1 , April 1929 , pp. 82 - 116
Copyright
Copyright © Cambridge University Press 1929

References

REFERENCES

Armstrong, C. (1926). Outbreaks of Milk-Borne Diseases. Intern. Assoc. Dairy and Milk Inspection 15th Annual Report, p. 186.Google Scholar
Arnold, , Lloyd, (1926, 1). Experimental Method for Study of Bacterial Flora of Gastro-Intestinal Tract. J. Infect. Diseases, 38, 246.CrossRefGoogle Scholar
Arnold, , Lloyd, (1926, 3). Influence of Acidified Milk on Duodenal Function in Infants. Amer. J. Dis. of Children, 31, 668.Google Scholar
Arnold, , Lloyd, (1927, 1). Diarrhoea in Infants. Arch. Pediatrics, 44, 71.Google Scholar
Arnold, , Lloyd, (1927, 3). Host Susceptibility to Typhoid, Dysentery, Food-Poisoning and Diarrhoea. J. Amer. Med. Assoc. 89, 789.CrossRefGoogle Scholar
Arnold, , Lloyd, (1927, 4). The Auto-Sterilising Mechanism of the Gastro-Intestinal Tract. A Note on the use of Dilute Acids in the Prevention and Treatment of Cholera. Indian Med. Gaz. 62, 344.Google ScholarPubMed
Arnold, , Lloyd, (1928, 3). The Passage of Living Bacteria through the Wall of the Intestine and the Influence of Diet and Climate upon Intestinal Auto-disinfection. Amer. J. Hyg. 8, 604.Google Scholar
Arnold, , Lloyd, (1928, 5). Food-Poisoning. Illinois State Med. J. 53, 353.Google Scholar
Arnold, , Lloyd, and Brody, L. (1926, 2). Bacterial Flora and Hydrogen-ion Concentration of Duodenum. J. Infect. Diseases, 38, 249.CrossRefGoogle Scholar
Arnold, , Lloyd, and Brody, L. (1926, 4). Gastro-Duodenal Bactericidal Mechanism. Amer. J. Hygiene, 6, 672.Google Scholar
Arnold, , Lloyd, and Brody, L. (1927, 2). Influence of “Effective Temperature” upon Bactericidal Action of the Gastro-Intestinal Tract. Proc. Soc. Exp. Biol. & Med. 24, 832.CrossRefGoogle Scholar
Arnold, , Lloyd, and Brody, L. (1928, 1). Passage of Living Bacteria through the Intact Intestinal Mucosa. Proc. Soc. Exp. Biol. & Med. 25, 247.CrossRefGoogle Scholar
Arnold, , Lloyd, and Finder, J. G. (1928, 2). Influence of Oral Administration of Bile upon Fasting Gastric Acidity and Intestinal Bactericidal Action. Proc. Soc. Exp. Biol. & Med. 25, 615.CrossRefGoogle Scholar
Arnold, , Lloyd, , Ostrom, M. L. and Singer, C. (1928, 4). Auto-Sterilizing Power of Nasal Mucosa. Proc. Soc. Exp. Biol. & Med. 25, 624.CrossRefGoogle Scholar
Arnold, , Lloyd, and Weiss, E. (1926). Prophylactic and Therapeutic Possibilities of the Twort-D'Herelle's Bacteriophage. J. Lab. and Clin. Med. St Louis, 12, 20.Google Scholar
Arquin, S. (1928). Stomach Tonus and Peripheral Leucocyte Count (Splanchnoperipheral Balance). Arch. Int. Med. 41, 913.CrossRefGoogle Scholar
Ballot, A. M. (1865). Karnemelk als voedsel voor kinderen beneden het jaar. Nederl. Tijdschr. v. Geneesk. 2 ser., 1, 402.Google Scholar
Barbour, H. G., Dawson, M. H. and Neuwirth, I. (1925). Water, Salt and Lipoid Accumulation in the Serum as a Preliminary to Sweating. Amer. J. Physiol. 74, 204.CrossRefGoogle Scholar
Barbour, H. G. and Hamilton, W. F. (1925, 1). Evidence that Cold Anhydremia is due to loss of fluid from the Blood Stream. Amer. J. Physiol. 73, 315.CrossRefGoogle Scholar
Barbour, H. G. and Hamilton, W. F. (1925, 2). The Fate of the Fluid leaving the Blood in Cold Anhydremia. Amer. J. Physiol. 73, 321.Google Scholar
Besredka, A. (1927). Local Immunisation: Specific Dressings. Baltimore: Williams & Wilkins.Google Scholar
Bienstock, B. (1884). Ueber die Bakterien der Faeces. Zeitschr. f. klin. Med. 8, 1.Google Scholar
Brownlee, J. and Young, M. (1922). The Epidemiology of Summer Diarrhoea. Proc. Roy. Soc. Med. (Sect. Epidemiol.), 15, 55.Google ScholarPubMed
Calmette, A. (1923). Les vaccinations microbiennes par voie buccale. Ann. Inst. Pasteur, 37, 900.Google Scholar
Carnot, P. and Gruzewska, F. (1925). Variations de concentration ionique de la bile et du sac pancréatique pendant la sécrétion acide du sac gastrique. Compt. Rend. Soc. Biol. 93, 240.Google Scholar
Carnot, P. and Gruzewska, F. (1926). La concentration ionique de la bile et sa teneur en CO2 pendant la sécrétion gastrique. Compt. Rend. Soc. Biol. 94, 369.Google Scholar
Cornwall, J. W. and Le Frenais, H. M. (1924). The Mechanism of Infection of B. typhosus. Indian J. Med. Res. 11, 883.Google Scholar
Ecker, E. E. and Wolpaw, B. J. (1926). The Failure of a Paratyphoid Vaccine to Confer Specific Resistance to Paratyphoid Intoxication. J. Prev. Med. 1, 145.Google Scholar
Ficker, M. (1904). Ueber die Keimdichte der normalen Schleimhaut des Intestinaltraktus. Arch. f. Hyg. 52, 179.Google Scholar
Ficker, M. (1905). Ueber den Einfluss des Hungers auf die Bakterien Durchlässigkeit des Intestinaltraktus. Arch. f. Hyg. 54, 354.Google Scholar
Ficker, M. (1906). Ueber den Einfluss der Erschöpfung auf die Keimdurchlässigkeit des Intestinaltraktus. Arch. f. Hyg. 57, 56.Google Scholar
Freezer, C. R. E., Gibson, C. S. and Mathews, E. (1928). A Contribution to the Study of “Alkalis” as Therapeutic Agents. Ouy's Hospital Rep. 78, 191.Google Scholar
Gaensslen, M. (1927). Der Einfluss veranderter Nahrung auf den periphersten Gefässabschnitt. Klin. Wochenschr. 6, 786.CrossRefGoogle Scholar
Gay, F. P. (1928). Local and Tissue Immunity. Newer Knowledge of Bacteriology, etc. Chicago: Jordan and Falk.Google Scholar
Gessner, C. (1889). Ueber die Bakterien im Duodenum des Menschen. Arch. f. Hyg. 9, 128.Google Scholar
Hahn, H., Klocman, L. and Moro, E. (1916). Experimentelle Untersuchungen zur endogenen Infektion des Dünndarms. Jahrb. f. Kinderh. 84, 10.Google Scholar
Hektoen, L. (1911). On the Local Production of Antibodies. J. Infect. Diseases, 9, 103.CrossRefGoogle Scholar
Hoelzel, F. (1926). The Effect of Variations in Protein Intake on the Acidity of the Secretion of the Fasting Stomach. Amer. J. Physiol. 77, 166.CrossRefGoogle Scholar
Jordan, E. O. and Geiger, J. C. (1923). Two “Food Poisoning” Outbreaks apparently due to Bacilli of the Paratyphoid Enteritidis Group. J. Infect. Diseases, 32, 471.CrossRefGoogle Scholar
Kisskalt, K. (1915). Das jahreszeitliche Auftreten der Kriegsseuchen. Deutsch. med. Wochenschr. p. 579.Google Scholar
Knorr, M. (1926). Akute Gastroenteritis und typhöser Paratyphus. Centralbl. Bakt. etc., Orig. Abt. 1, 99, 25.Google Scholar
Leach, C. N., Dehler, S. A. and Havens, L. C. (1926). The Prevalence of Carriers among Recovered Typhoid Patients. Amer. J. Pub. Health, 16, 391.CrossRefGoogle ScholarPubMed
Moclendon, J. F., Bissel, F. S., Lowe, E. R. and Meyer, P. F. (1920). Hydrogen-ion Concentration of the Content of the Small Intestine. J. Amer. Med. Assoc. 75, 1639.Google Scholar
Meyer, E. (1927). Die Einwirkung parentaler Eiweisszufuhr auf den Gasstoffwechsel. Zeitschr. f. ges. exp. Med. 55, 649.CrossRefGoogle Scholar
Mills, C. A. (1928). Functional Insufficiency of the Suprarenal Glands. Arch. Int. Med. 42, 390.CrossRefGoogle Scholar
Mills, C. A. and Necheles, H. (1927). Specific Dynamic Action of Food and Blood Coagulability. Proc. Soc. Exp. Biol. & Med. 25, 195.CrossRefGoogle Scholar
Moro, E. (1916). Bemerkungen zur Lehre von der Säuglingsernährung. II. Die endogene Infektion des Dünndarms. Jahrb. f. Kinderh. 84, 1.Google Scholar
Mueller, E. F. (1926). Evidence of Nervous Control of Leucocytic Activity by the Involuntary Nervous System. Arch. Int. Med. 37, 268.CrossRefGoogle Scholar
Mueller, E. F. and Petersen, W. F. (1927, 1). Ueber die Wirkung der Protein-Körperinjektion auf die Mageninnervation. München. med. Wochenschr. 74, 531, 588.Google Scholar
Mueller, E. F. and Petersen, W. F. (1926, 2). Die Bedeutung der physiologischen Schwankungen der peripheren Leukocytenzahlen. Ihre Beziehungen zur Mageninnervation. Klin. Wochenschr. 5, 137.CrossRefGoogle Scholar
Mueller, E. F. and Kast, L. (1928). Ueber die Bedeutung der physiologischen Schwankungen der peripheren Leukooytenzahlen. III. Ihre Beziehung zur Gallenproduktion. Klin. Wochenschr. 7, 450.CrossRefGoogle Scholar
Neisser, M. (1896). Ueber die Durchgängigkeit der Darmwand für Bakterien. Zeitschr. f. Hyg. u. Infektionskr. 22, 12.Google Scholar
Peters, O. H. (1911). Observations upon the Natural History of Epidemic Diarrhoea. Cambridge: University Press.Google Scholar
Petersen, W. F. (1922). Protein Therapy and Non-specific Resistance. New York: Mac-millan.CrossRefGoogle Scholar
Petersen, W. F. and Mueller, E. F. (1927). The Splanchnoperipheral Balance, during Chill and Fever. Arch. Int. Med. 40, 575.CrossRefGoogle Scholar
Petersen, W. F., Milles, G. and Mueller, E. F. (1928). Ueber Aenderungen des Kalium-Calcium-Quotienten der Lymphe bei experimenteller Sepsis. Zeitschr. f. d. ges. exp. Med. 60, 336.CrossRefGoogle Scholar
Petersen, W. F. and Oettingen, V. (1927). Veranderungen der Lymphe beim Hunde nach Quarzlichtbestrahlungen. Arch. f. exp. Path. u. Pharm. 123, 160.CrossRefGoogle Scholar
Pollitzer, H. and Stolz, E. (1925). Untersuchungen zur Pathologie des respiratorischen Stoffwechsels. Wien. Arch. f. inn. Med. 9, 307; 10, 137; 11, 319; 12, 169.Google Scholar
Rolly, and Liebermeister, G. (1905). Experimentelle Untersuchungen iiber die Ursachen der Abtötung von Bakterien im Dünndarm. Deulsch. Arch. f. klin. Med. 83, 413.Google Scholar
Ross, W. C. and Bagchi, K. N. (1918-1919). The Seasonal Variation in the Reaction and Hardness of River Water in India. Indian J. Med. Research, 6, 423.Google Scholar
Russell, A. J. H. (1925-1926). A Memorandum on the Epidemiology of Cholera. Indian J. Med. Res. 13, 637.Google Scholar
Savage, W. G. and White, P. F. (1925). An Investigation of the Salmonella Group with Special Reference to Food-Poisoning. Medical Res. Council Special Report Series, No. 90.Google Scholar
Schottmueller, H. (1904). Zur Etiologie der akuten Gastro-enteritia. (Cholera nostras.) München. med. Wochenschr. 51, 294 and 349.Google Scholar
Schuetz, R. (1901). Kritischerund experimenteller Beitrag zur Frage der Gastro-Intestinalen Desinfection. Arch. f. Verdauungskr. 7, 43.CrossRefGoogle Scholar
Scholberg, H. A. and Wallis, R. L. M. (1910). Report on the Chemical Changes Produced in Milk by Bacteria and their Relation to the Epidemic Diarrhoea in Infants. 39th Annual Report, Local Government Board—1909–10, pp. 109, 504.Google Scholar
Semple, D. and Greig, E. D. W. (1908). An Enquiry on Enteric Fever in India. Sci. Mem. by Officers of Medical and Sanit. Dep., Govt. of India, No. 32.Google Scholar
Thiele, F. H. and Embleton, D. (1913-1914). Infection: Paths of Spread in Bacterial Infection. Proc. Roy. Soc. Med. (Path. Sec), 7, 69.CrossRefGoogle Scholar
Toenniessen, E. (1923). Die Bedeutung des vegetativen Nervensystems für die Wärme-regulation und den Stoffwechsel. Ergebn. d. inn. Med. u. Kinder. 23, 141.Google Scholar
Underhill, F. P. and Simpson, G. E. (1920). The Effect of Diet on the Excretion of Indican and the Phenols. J. Biol. Ohem. 44, 69.CrossRefGoogle Scholar
Van der Ries, V. (1925). Die Darmbakterien des Erwachsenen und ihre klinische Bedeutung. Ergebn. d. inn. Med. u. Kinder. 27, 77.Google Scholar
Wassermann, A. and Citron, J. (1911). Ein Beitrag zur Frage der localen Immunität der Gewebe. Zeitschr. f. Hyg. 68, 346.Google Scholar
Weichardt, W. (1926). Unspezifische Immunität. Jena: Fischer.Google Scholar