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An outbreak of cowpox in captive cheetahs: virological and epidemiological studies

  • D. Baxby (a1), D. G. Ashton (a2), D. M. Jones (a2) and L. R. Thomsett (a3)

This paper describes virological and epidemiological features of an infection which killed two of three affected cheetahs at Whipsnade Park in 1977. Two animals had profuse skin lesions and the third had an acute haemorrhagic pneumonia. The outbreak was shown to be caused by cowpox virus. Cowpox virus is believed to circulate in small wild animals, but the source of infection was not traced despite virological and serological tests on 93 captive and 102 wild animals.

Sub-clinical infections did not occur in susceptible contact cheetahs. Immune globulin did not influence the outcome and smallpox vaccine does not take in cheetahs. Management of any future outbreak will rely on prompt diagnosis and segregation of infected animals.

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Barnard J. E. & Elford W. J. (1931). The causative organism in infectious ectromelia. Proceedings of the Royal Society B 109, 360380.
Baxby D. (1975). Identification and interrelationships of the variola/vaccinia subgroup of poxviruses. Progress in Medical Virology 19, 215246.
Baxby D. (1977). Is cowpox misnamed? a review often human cases. British Medical Journal i, 13791381.
Baxby D. & Ghaboosi B. (1977). Laboratory characteristics of poxviruses isolated from captive elephants in Germany. Journal of General Virology 37, 407414.
Baxby D., Shackleton W. B., Wheeler J. & Turner A. (1979). Comparison of cowpox-like viruses isolated from European zoos. Archives of Virology 61, 337340.
Boulter E. A. (1957). The titration of vaccinial neutralizing antibody on chorio-allantoic membranes. Journal of Hygiene 55, 502512.
Davies J. H. T., Janes L. R. & Downie A. W. (1938). Cowpox infection in farmworkers. Lancet ii, 15341537.
Downie A. W. (1939 a). A study of the lesions produced experimentally by cowpox virus. Journal of Pathology and Bacteriology 48, 361379.
Downie A. W. (1939 b). The immunological relationship of the virus of spontaneous cowpox to vaccinia virus. British Journal of Experimental Pathology 20, 158176.
Goodpasture E. W. (1928). Diseases of fowls as exemplified by contagious epithelioma (fowlpox) of chickens and pigeons. In Filterable Viruses (ed. Rivers T. M.), pp. 233277. Baltimore: Williams & Wilkins.
Kaplan C., Healing T. D., Evans N., Healing L. & Prior A. (1980). Evidence for infection by viruses in small British field rodents. Journal of Hygiene 84, 285294.
Marennikova S. S., Maltseva N. N., Korneeva V. I. & Garanina N. M. (1977). Outbreak of pox disease among Carnivora (Felidae) and Edentata. Journal of Infectious Diseases 135, 358366.
Marennikova S. S. & Shelukhina E. M. (1976). White rats as a source of pox infection in Carnivora of the family Felidae. Acta Virologica 20, 442.
McCarthy K. & Helbert D. (1960). A comparison of the haemagglutinins of variola, alastrim, vaccinia, cowpox and ectromelia viruses. Journal of Pathology and Bacteriology 79, 416420.
Thomsett L. R., Baxby D. & Denham E. M. (1978). Cowpox in the domestic cat. Veterinary Record 108, 567.
Zwart P., Gispen R. & Peters J. C. (1970). Cowpox in okapis Okapia johnstoni at Rotterdam zoo. British Veterinary Journal 127, 2024.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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