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An outbreak of rubella in the Federation of Bosnia and Herzegovina between December 2009 and May 2010 indicates failure to vaccinate during wartime (1992–1995)

  • M. HUKIC (a1), J. M. HÜBSCHEN (a2), M. SEREMET (a1), I. SALIMOVIC-BESIC (a1), M. MULAOMEROVIC (a3), N. MEHINOVIC (a4), S. KARAKAS (a5), E. CHARPENTIER (a2) and C. P. MULLER (a2)...

A rubella outbreak involving 1900 cases was recorded in the Federation of Bosnia and Herzegovina between mid-December 2009 and the end of May 2010. Sera from 389 suspected rubella cases were examined for the presence of rubella-specific IgM and IgG antibodies. A total of 32 throat swabs from suspected rubella cases were tested by RT–PCR and were used to attempt virus isolation. Most patients (945/1900, 49·73%) had never received rubella vaccination or had an unknown vaccination status (563/1900, 29·63%). About 45% (178/389) of suspected rubella patients were IgM positive. From 13 of the throat swabs a virus isolate and E1 gene sequences attributed to genotype 2B were obtained. The rubella outbreak was due to failure to vaccinate during the war period (1992–1995) and emphasizes the need for additional vaccination opportunities.

Corresponding author
*Author for correspondence: Prof. Dr. C. P. Muller, Institute of Immunology, Centre de Recherche Public Santé/Laboratoire National de Santé, 20A rue Auguste Lumière, L-1950 Luxembourg. (Email: claude.muller@LNS.ETAT.LU)
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1.J Chantler , JS Wolinsky , A Tingle . Rubella virus. In: BN Fields , DM Knipe , PM Howley , eds. Fields Virology, 4th edn, vol. 1., Philadelphia: Lippincott-Raven Publishers, 2001, pp. 963990.

3.World Health Organization. Strategic plan for measles and congenital rubella infection in the European region of WHO. World Health Organization Regional Office for Europe, Copenhagen, Denmark ( Accessed 25 September 2007.

5.Institute of Public Health. Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina. Epidemiological bulletins of the Institute of Public Health, volumes 16–28, 1997–2009.

6.JM Hübschen , A multiplex TaqMan PCR assay for the detection of measles and rubella virus. Journal of Virological Methods 2008; 149: 246250.

7.World Health Organization.Manual for the Laboratory Diagnosis of Measles and Rubella Virus Infection, 2nd edn.Geneva, Switzerland: Department of Immunization, Vaccines and Biologicals ( Accessed 5 May 2010.

8.S Kumar , K Tamura , M Nei . MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Briefings in Bioinformatics 2004; 5: 150163.

10.World Health Organization.Update of standard nomenclature for wild-type rubella viruses, 2007. Weekly Epidemiological Record 2007; 82: 216222.

12.JM Hübschen , CP Muller . Rubella and Congenital Rubella. In: ET Bope , R Kellerman , RE Rakel , eds. Conn's Current Therapy 2011. Philadelphia, USA: Elsevier Saunders, 2011, pp. 141142.

13.P D'Agaro , Epidemiological and molecular assessment of a rubella outbreak in North-Eastern Italy. Journal of Medical Virology 2010; 82: 19761982.

15.S Kasper , Rubella in Austria 2008–2009: no longer a typical childhood disease. Pediatric Infectious Disease Journal 2010; 29: 448452.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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