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Antibodies to Eubacterium and Peptostreptococcus species and the estimated probability of Crohn's disease

Published online by Cambridge University Press:  25 March 2010

J. P. Van de Merwe ,
P. I. M. Schmitz  and
F. Wensinck
J. P. Van de Merwe
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
P. I. M. Schmitz
Affiliation:
Institute of Biostatistics, Erasmus University, Rotterdam, The Netherlands
F. Wensinck
Affiliation:
Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands
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Summary

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Anaerobic coccoid rods belonging to species of Eubacterium and Peptostreptococcus agglutinate more frequently with sera from patients with Crohn's disease than with sera from patients suffering from other diseases and from healthy subjects. Results of agglutination tests with four strains of coccoid anaerobes were used to estimate the probability that a patient suffers from Crohn's disease. The data on healthy subjects and patients with Crohn's disease were subjected to logistic discriminant analysis. With the methods and interpretation described, 52% of the patients with Crohn's disease were recognized as ‘definite’ or ‘probable’ Crohn's disease and 14% as ‘suspected’. Only 1% of the healthy subjects were classified as ‘suspected’ and none as ‘definite’ or ‘probable’ Crohn's disease.

Type
Research Article
Information
Journal of Hygiene , Volume 87 , Issue 1 , August 1981 , pp. 25 - 33
Copyright
Copyright © Cambridge University Press 1981

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