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Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant

  • J. A. Mumford (a1), H. Wilson (a2), D. Hannant (a1) and D. M. Jessett (a1)

Equine influenza vaccines containing inactivated whole virus and Carbomer adjuvant stimulated higher levels and longer lasting antibody to haemagglutinin in ponies than vaccines of equivalent antigenic content containing aluminium phosphate adjuvants. Five months after the third dose of vaccine containing Carbomer adjuvant, ponies were protected against clinical disease induced by an aerosol of virulent influenza virus (A/equine/Newmarket/79, H3N8). In contrast ponies which received vaccine containing aluminium phosphate adjuvant were susceptible to infection and disease. There was an inverse correlation between prechallenge levels of antibody detected by single radial haemolysis (SRH) and duration of virus excretion, pyrexia and coughing. All ponies with antibody levels equivalent to SRH zones of ≥ 154 mm2 were protected against infection and all those with levels ≤ 85 mm2 were protected from disease.

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Hinshaw VS Naeve CW, Webster RG, Douglas A Skehel JJ Bryans J. Analysis of antigenic variation in equine 2 influenza A viruses. Bull WHO 1983: 61: 153–8.
Burrows R, Spooner PR, Goodridge D. A three-year evaluation of four commercial equine influenza vaccines in ponies maintained in isolation. International Symposium on Influenza Immunisation (II) 1977; 39: 341–6.
Mumford JA, Wood JM, Folkers C, Schild G. Protection against experimental infection with influenza virus A/equine/Miami/63 (H3N8) provided by inactivated whole virus vaccines containing homologous virus. Epidemiol Infect 1988: 100: 501–10.
Wood JM, Schild GC, Folkers C, Mumford J, Newman RW. The standardisation of inactivated equine influenza vaccines by single–radial immunodiffusion. J Biol Stand 1983; 11: 133–6.
Mumford JA, Wood JM Scott AM, Folkers C, Schild GC. Studies with inactivated equine influenza vaccine. 2. Protection against experimental infection with influenza virus A/equine/Newmarket/79 (H3N8). J Hyg 1983; 90: 385–95.
Burrows R, Goodridge D, Denyer M, Hutchings G Frank CJ. Equine influenza infections in Great Britain 1979. Vet Rec 1982; 110: 494–7.
7. Carbomer 934P. USP XXII, NF XVII. United States Pharmacopeial Convention Inc., Rockville. Maryland, 1990: 1911.
Mumford JA Hannant D, Jessett DM. Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine Vet J 1990: 22: 93–8.
Wood JM Mumford J Folkers C, Scott AM, Schild GC. Studies with inactivated equine influenza vaccine. 1. Serological responses of ponies to graded doses of vaccine. J Hyg 1983: 90: 371–84.
Haaheim LR, Schild GC. Antibodies to strain–specific and cross–reactive determinants of the haemagglutinin of influenza H3N8 viruses. Acta Path Microbiol Scand (Section B) 1980; 88: 335–40.
Virelizier JL. Host defences against influenza; the role of anti–haemagglutinin antibody. J Immunol 1975; 115: 434–9.
Hannant D, Jessett DM O'Neill T, Sundquist B, Mumford JA. Nasopharyngeal, tracheobronchial, and systemic immune responses to vaccination and aerosol infection with equine–2 influenza A virus (H3N8). In: Powell DG ed. Proceedings of the 5th International Conference on Equine Infectious Diseases. Lexington: Kentucky University Press, 1988: 6673.
Hannant D, Mumford JA. Cell mediated immune responses in ponies following infection with equine influenza virus (H3N8): the influence of induction culture conditions on the properties of cytotoxic effector cells. Vet Immunol Immunopath 1989; 21: 327–37.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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