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Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant

  • J. A. Mumford (a1), H. Wilson (a2), D. Hannant (a1) and D. M. Jessett (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268800057848
  • Published online: 01 May 2009
Abstract
SUMMARY

Equine influenza vaccines containing inactivated whole virus and Carbomer adjuvant stimulated higher levels and longer lasting antibody to haemagglutinin in ponies than vaccines of equivalent antigenic content containing aluminium phosphate adjuvants. Five months after the third dose of vaccine containing Carbomer adjuvant, ponies were protected against clinical disease induced by an aerosol of virulent influenza virus (A/equine/Newmarket/79, H3N8). In contrast ponies which received vaccine containing aluminium phosphate adjuvant were susceptible to infection and disease. There was an inverse correlation between prechallenge levels of antibody detected by single radial haemolysis (SRH) and duration of virus excretion, pyrexia and coughing. All ponies with antibody levels equivalent to SRH zones of ≥ 154 mm2 were protected against infection and all those with levels ≤ 85 mm2 were protected from disease.

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JM Wood , GC Schild , C Folkers , J Mumford , RW Newman . The standardisation of inactivated equine influenza vaccines by single–radial immunodiffusion. J Biol Stand 1983; 11: 133–6.

R Burrows , D Goodridge , M Denyer , G Hutchings CJ Frank . Equine influenza infections in Great Britain 1979. Vet Rec 1982; 110: 494–7.

JA Mumford D Hannant , DM Jessett . Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine Vet J 1990: 22: 93–8.

D Hannant , JA Mumford . Cell mediated immune responses in ponies following infection with equine influenza virus (H3N8): the influence of induction culture conditions on the properties of cytotoxic effector cells. Vet Immunol Immunopath 1989; 21: 327–37.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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