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Attempts to infect pigs with Coxsackie virus type B5

Published online by Cambridge University Press:  15 May 2009

A. J. M. Garland  and
J. A. Mann
A. J. M. Garland
Affiliation:
Animal Virus Research Institute, Pirbright, Woking, Surrey
J. A. Mann
Affiliation:
Animal Virus Research Institute, Pirbright, Woking, Surrey
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Summary

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Despite the existence of a close serological relationship between the entero-viruses Swine Vesicular Disease (SVD) and Coxsackie type B5 (Cx B5), the administration of this Coxsackie virus type to susceptible pigs by various routes failed to produce clinical disease.

Viraemia was not detected after exposure but virus was recovered intermittently from faeces and buccal swabs. A mixed virus population was demonstrated in faecal cultures from some pigs, including Coxsackie virus type B5 and other agents, presumably native pig enteroviruses. The Coxsackie virus persisted in faeces in declining amounts for up to 8 days after primary exposure.

Serum neutralizing antibody showed a transient rise to Coxsackie virus, reaching a peak at 14 days and declining below demonstrable titres by 28 days after exposure. The antibody titres attained were proportional to the dose of virus administered and the degree of neutralization was very similar to both SVD and Cx B5 viruses.

On cross challenge by exposure to SVD virus 28 days after exposure to Cx B5 virus, most animals (5/6) succumbed with typical vesicular lesions, although the serum neutralizing antibody titres showed a characteristically anamnestic response to both viruses.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 1 , August 1974 , pp. 85 - 96
Copyright
Copyright © Cambridge University Press 1974

References

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