Skip to main content Accessibility help
×
Home
Hostname: page-component-684899dbb8-bjz6k Total loading time: 0.225 Render date: 2022-05-16T22:24:40.923Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true }

Bacterial flora of Tasmanian SIDS infants with special reference to pathogenic strains of Escherichia coli

Published online by Cambridge University Press:  15 May 2009

S. S. Bettiol
Affiliation:
University of Tasmania, Department of Pathology, 43 Collins Street, Hobart, Tasmania 7000, Australia
F. J. Radcliff
Affiliation:
University of Tasmania, Department of Pathology, 43 Collins Street, Hobart, Tasmania 7000, Australia
A. L. C. Hunt
Affiliation:
University of Tasmania, Department of Pathology, 43 Collins Street, Hobart, Tasmania 7000, Australia
J. M. Goldsmid
Affiliation:
University of Tasmania, Department of Pathology, 43 Collins Street, Hobart, Tasmania 7000, Australia
Rights & Permissions[Opens in a new window]

Summary

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The general bacterial flora of 38 Tasmanian SIDS infants was examined together with faecal flora of 134 comparison infants ranging in age from birth to 6 months. The microflora of all specimens received was investigated with special emphasis on the toxigenic Escherichia coli (TEC). Samples were examined for verocytotoxigenic E. coli, free faecal verocytotoxin (FVT), heat labile toxin (LT) and heat stable toxin (ST) producers with the use of a Vero cell assay and commercial kits. The findings of this study revealed a high isolation rate (39%) of TEC from SIDS infants as compared to 1.5% from the healthy comparison infants. Atypical E. coli strains were also identified during the study, including E. coli A–D. An analysis of the same specimens for rotaviral and adenoviral antigens indicated that 30% of the SIDS cases were positive as compared to 20% in the comparison group.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1994

References

Knight, B. Sudden death in infancy – the cot death syndrome. London: Faber & Faber. 1983: 1741.Google Scholar
McGlashin, ND. Sudden infant deaths in Tasmania, 1980–1986: a seven year prospective study. Soc Sci Med 1989: 8: 1015–26.CrossRefGoogle Scholar
Althoff, H. Sudden Infant Death Syndrome (SIDS). Stuttgart, New York: Gustav Fischer Verlag. 1980.Google Scholar
Lee, S, Barson, AJ, Drucker, DB, Morris, JA, Telford, DR. Lethal challenge of gnotobiotic weanline rats with bacterial isolates from cases of sudden infant death syndrome (SIDS). J Clin Pathol 1987; 40: 1393–6.CrossRefGoogle Scholar
Harrison, DFN. Histologic evaluation of the larynx in SIDS. Ann Otol Rhinol Laryngol 1991; 100: 173–5.CrossRefGoogle Scholar
6. World Health Organisation. Causes of infant death by sex and age. World Health Statistics Annual 1990. Geneva: WHO. 409–10.Google Scholar
Newman, NM. The epidemiology of Sudden Infant Death Syndrome in Australia, with particular reference to Tasmania, 1975–1981. In: Harper, RM, Hoffman, HJ, eds. Sudden Infant Death Syndrome – risk factors and basic mechanisms. New York: PMA Publishing Corp, 1988.Google Scholar
Gilbert, R, Rudd, P, Berry, PJ et al. , Combined effect of infection and heavy wrapping on the risk of sudden unexpected infant death. Arch Dis Child 1992; 67: 171–7.CrossRefGoogle ScholarPubMed
Sonnabend, OAR, Sonnabend, WFF, Krech, U, Molz, G, Sigrist, T. Continuous microbiological and pathological study of 70 sudden and unexpected infant deaths: toxigenic intestinal Clostridium botulinum infection in 9 cases of sudden infant death syndrome. Lancet 1985; i: 237–41.CrossRefGoogle Scholar
Morris, JA, Haran, D, Smith, A. Hypothesis: common bacterial toxins are a possible cause of the Sudden Infant Death Syndrome. Med Hypotheses 1987; 22: 211–22.CrossRefGoogle ScholarPubMed
Telford, DR, Morris, JA, Hughes, P et al. , The nasopharyngeal bacterial flora in the sudden infant death syndrome. J Infect 1989; 18: 125–30.CrossRefGoogle ScholarPubMed
Dwyer, T, Ponsonby, ALB, Newman, NM, Gibbons, LE. Prospective cohort study of prone sleeping position and sudden infant death syndrome. Lancet 1991; 337: 1244–7.CrossRefGoogle ScholarPubMed
Scott, DJ, Gardner, PS, McQuillan, J, Stanton, AN, Downham, MAPS. Respiratory viruses and cot death. B M J 1978; 2: 1213.CrossRefGoogle ScholarPubMed
McKendrick, N, Drucker, DB, Morris, JA et al. , Bacterial toxins: a possible cause of cot death. J Clin Pathol 1991; 45: 4953.CrossRefGoogle Scholar
Arnon, SS. Breast–feeding and toxigenic intestinal infections: missing links in SIDS? In: Tildon, JT, Roeder, LM, Steinschneider, A, eds. Sudden Infant Death Syndrome. London: Academic Press; 1983: 539–55.Google Scholar
Morris, JA, Malam, JE, Carrick, GF, Telford, DR. Staphylococcal toxins and cot death. J Med Microbiol (J Path Soc of Great Britain and Ireland, 165th Meeting) 1992: A293.Google Scholar
Drucker, DB, Aluyi, HS, Telford, DR, Morris, JA. Lethal synergy of toxin preparations from bacteria associated with cot–death. J Med Microbiol (J of Path Soc of Great Britain and Ireland, 165th Meeting): 1992: A294.Google Scholar
Bettelheim, KA, Goldwater, PN, Dwyer, BW, Bourne, AJ, Smith, DL. Toxigenic Escherichia coli associated with sudden infant death syndrome. Scand J Infect Dis 1990; 22: 467–76.CrossRefGoogle ScholarPubMed
Bettelheim, KA, Dwyer, BW, Smith, DL, Goldwater, PN, Bourne, AJ.. Toxigenic Escherichia coli associated with sudden infant death syndrome. Med J Aust 1989; 151: 538.Google ScholarPubMed
Luke, R, Bettelheim, K, Agbodaze, D, Evangelidis, H, Pearce, J, Goldwater, P. Escherichia coli toxins and sudden infant death syndrome (SIDS). Research Network News (National SIDS Council) 1992; 3: 78.Google Scholar
Hunt, ALC. A study of shigellosis in Tasmania. Master of Medical Science Qualifying Thesis, Hobart, Tasmania, University of Tasmania, 1989.Google Scholar
Bettiol, SS. An investigation of Escherichia coli (A–D) in Tasmania. Honours Qualifying Thesis, Hobart, Tasmania, University of Tasmania, 1989.Google Scholar
Karmali, MA. Laboratory diagnosis of verocytotoxin–producing Escherichia coli infections. Culture (Oxoid) 1988; Sep 9: 14.Google Scholar
Karmali, MA. Infection by verocytotoxin–producing Escherichia coli. Clin Microbiol Rev 1989; 2: 1538.CrossRefGoogle ScholarPubMed
Gross, RJ, Rowe, B. Escherichia coli diarrhoea. In: Microbes and infection of the gut, Goodwin, CS, ed. Melbourne: Blackwell Scientific Publications, 1984: 7994.Google Scholar
Law, D, Ganguli, LA, Donohue-Rolfe, A, Acheson, DWK. Detection by enzyme–linked immunoabsorbent assay of low numbers of shiga–like toxin producing Escherichia coli in mixed cultures after growth in the presence of mitomycin C. J Med Microbiol 1992; 36: 198202.CrossRefGoogle Scholar
Losonsky, G. Diarrhoea and gastroenteritis. Current Opinion Infect Dis 1992; 5: 576–81.CrossRefGoogle Scholar
Bettiol, SS, Hunt, ALC, Goldsmid, JM. The clinical significance of Escherichia coli Alkalescens–Dispar (A–D) in Tasmania. Israel J Med Sci. In press.Google Scholar
Kallenius, G, Molby, R, Svenson, SB et al. , Occurrence of P–fimbriated Escherichia coli in urinary tract infections. Lancet 1981; ii: 1369–72.CrossRefGoogle Scholar
Martinez, FD. Sudden infant death syndrome and small airway occlusion: facts and a hypothesis. Pediatrics 1991; 87: 190–8.Google Scholar
Ramfrez-Ronda, CH, Fuxengh-Lopez, Z, Nevarez, M. Increased pharyngeal bacterial colonization during viral illness. Arch Intern Med 1981; 141: 1599–603.CrossRefGoogle Scholar
You have Access
28
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Bacterial flora of Tasmanian SIDS infants with special reference to pathogenic strains of Escherichia coli
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Bacterial flora of Tasmanian SIDS infants with special reference to pathogenic strains of Escherichia coli
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Bacterial flora of Tasmanian SIDS infants with special reference to pathogenic strains of Escherichia coli
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *