Skip to main content Accessibility help
×
×
Home

Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England

  • K. M. HANSFORD (a1), M. FONVILLE (a2), S. JAHFARI (a2), H. SPRONG (a2) and J. M. MEDLOCK (a1)...
Summary

This paper reports the first detection of Borrelia miyamotoi in UK Ixodes ricinus ticks. It also reports on the presence and infection rates of I. ricinus for a number of other tick-borne pathogens of public health importance. Ticks from seven regions in southern England were screened for B. miyamotoi, Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum and Neoehrlichia mikurensis using qPCR. A total of 954 I. ricinus ticks were tested, 40 were positive for B. burgdorferi s.l., 22 positive for A. phagocytophilum and three positive for B. miyamotoi, with no N. mikurensis detected. The three positive B. miyamotoi ticks came from three geographically distinct areas, suggesting a widespread distribution, and from two separate years, suggesting some degree of endemicity. Understanding the prevalence of Borrelia and other tick-borne pathogens in ticks is crucial for locating high-risk areas of disease transmission.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England
      Available formats
      ×
Copyright
Corresponding author
* Author for correspondence: Miss K. M. Hansford, Medical Entomology & Zoonoses Ecology Group, MRA&BS, Emergency Response Department, Public Health England, Porton Down, UK. (Email: kayleigh.hansford@phe.gov.uk)
References
Hide All
1. Jameson, LJ, Medlock, JM. Tick surveillance in Great Britain. Vector Borne and Zoonotic Diseases; 2011 11: 403412.
2. Hubbard, MJ, Baker, AS, Cann, KJ. Distribution of Borrelia burgdorferi s.l. spirochaete DNA in British ticks (Argasidae and Ixodidae) since the 19th century, assessed by PCR. Medical and Veterinary Entomology 1998; 12: 8997.
3. Dubrey, SW, et al. Lyme disease in the United Kingdom. Postgraduate Medical Journal 2014: 90: 3342.
4. Stanek, G, et al. Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clinical Microbiology and Infection 2011; 17: 6979.
5. Smith, FD, Wall, LER. Prevalence of Babesia and Anaplasma in ticks infesting dogs in Great Britain. Veterinary Parasitology 2013; 198: 1823.
6. Tijsse-Klasen, E, et al. Spotted fever group rickettsiae in Dermacentor reticulatus and Haemaphysalis punctata ticks in the UK. Parasites and Vectors 2013; 6: 212.
7. Stuen, S, Granquist, EG, Silaghi, C. Anaplasma phagocytophilum – a widespread multi-host pathogen with highly adaptive strategies. Frontiers in Cellular Infection Microbiology 2013; 3: 31.
8. Ogden, NH, et al. Granulocytic Ehrlichia infection in ixodid ticks and mammals in woodlands and uplands of the U.K. Medical and Veterinary Entomology 1998; 12: 423429.
9. Jahfari, S et al. Prevalence of Neoehrlichia mikurensis in ticks and rodents from North-west Europe. Parasites and Vectors 2012; 5: 74.
10. Andersson, M, Scherman, K, Råberg, L. Infection dynamics of the tick-borne pathogen ‘Candidatus Neoehrlichia mikurensis’ and co-infections with Borrelia afzelii in bank voles in Southern Sweden. Applied and Environmental Microbiology. Published online: 27 12 2013 . doi:10.1128/AEM.03469-13.
11. Holden, K, et al. Coinfection with Anaplasma phagocytophilum alters Borrelia burgdorferi population distribution in C3H/HeN mice. Infection and Immununity 2005; 73: 34403444.
12. Fraenkel, CJ, Garpmo, U, Berglund, J. Determination of novel Borrelia genospecies in Swedish Ixodes ricinus ticks. Journal of Clinical Microbiology 2002; 40: 33083312.
13. Geller, J, et al. Detection and genetic characterization of relapsing fever spirochete Borrelia miyamotoi in Estonian ticks. PLoS One 2012; 7: e51914.
14. Fukunaga, M, et al. Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. International Journal of Systematic Bacteriology 1995; 45: 804810.
15. Ullmann, AJ, et al. Three multiplex assays for detection of Borrelia burgdorferi sensu lato and Borrelia miyamotoi sensu lato in field-collected Ixodes nymphs in North America. Journal of Medical Entomology 2005; 42: 10571062.
16. Ogden, NH, et al. Investigation of genotypes of Borrelia burgdorferi in Ixodes scapularis ticks collected during surveillance in Canada. Applied and Environmental Microbiology 2011; 77: 32443254.
17. Richter, D, et al. Absence of Lyme disease spirochetes in larval Ixodes ricinus ticks. Vector Borne and Zoonotic Diseases 2012; 12: 2127.
18. Richter, D, Schlee, DB, Matuschka, FR. Relapsing fever-like Spirochetes infecting European vector tick of Lyme disease agent. Emerging and Infectious Diseases 2003; 9: 697701.
19. Hovius, JWR, et al. A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. Lancet 2013; 382: 658.
20. Wodecka, B. flaB gene as a molecular marker for distinct identification of Borrelia species in environmental samples by the PCR-restriction fragment length polymorphism method. Applied and Environmental Microbiology 2011; 77: 70887092.
21. Subramanian, G, et al. Multiple tick-associated bacteria in Ixodes ricinus from Slovakia. Ticks and Tick Borne Diseases 2012; 3: 406410.
22. Wilhelmsson, P, et al. Prevalence, diversity, and load of Borrelia species in ticks that have fed on humans in regions of Sweden and Åland islands, Finland with different Lyme borreliosis incidences. PLoS One 2013; 8: e81433.
23. Barbour, AG, et al. Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species. American Journal of Tropical Medicine and Hygiene 2009; 81: 11201131.
24. Chowdri, HR, et al. Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report. Annals of Internal Medicine 2013; 159: 2127.
25. Gugliotta, JL, et al. Meningoencephalitis from Borrelia miyamotoi in an immunocompromised patient. New England Journal of Medicine 2013; 368: 240245.
26. Krause, PJ, et al. Human Borrelia miyamotoi infection in the United States. New England Journal of Medicine 2013; 368: 291293.
27. Platonov, AE, et al. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerging Infectious Diseases 2011; 17: 18161823.
28. Hillyard, PD. Ticks of North-West Europe. London: Field Studies Council, 1996.
29. Heylen, D, et al. Transmission dynamics of Borrelia burgdorferi s.l. in a bird tick community. Environmental Microbiology 2013; 15: 663673.
30. Coipan, EC, et al. Spatiotemporal dynamics of emerging pathogens in questing Ixodes ricinus. Frontiers in Cellular and Infection Microbiology 2013; 3: 36.
31. Branda, JA, Rosenberg, ES. Borrelia miyamotoi: a lesson in disease discovery. Annals of Internal Medicine 2013; 159: 6162.
32. Stanek, G, et al. Borrelia transfer by ticks during their life cycle. Studies on laboratory animals. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology 1986; 263: 2933.
33. Bettridge, J, et al. Distribution of Borrelia burgdorferi sensu lato in Ixodes ricinus populations across Central Britain. Vector Borne and Zoonotic Diseases 2013; 13: 139146.
34. Vollmer, SA, et al. Host migration impacts on the phylogeography of Lyme borreliosis spirochaete species in Europe. Environmental Microbiology 2011; 13: 184192.
35. James, MC, et al. Environmental determinants of Ixodes ricinus ticks and the incidence of Borrelia burgdorferi sensu lato, the agent of Lyme borreliosis, in Scotland. Parasitology 2013; 140: 237246.
36. Guy, EC, Farquhar, RG. Borrelia burgdorferi in urban parks. Lancet 1991; 338: 253.
37. Junttila, J, et al. Prevalence of Borrelia burgdorferi in Ixodes ricinus ticks in urban recreational areas of Helsinki. Journal of Clinical Microbiology 1999; 37: 13611365.
38. Reis, C, et al. Questing ticks in suburban forest are infected by at least six tick-borne pathogens. Vector Borne and Zoonotic Diseases 2011; 11: 907916.
39. Corrain, R, et al. Study on ticks and tick-borne zoonoses in public parks in Italy. Zoonoses and Public Health 2012; 59: 468476.
40. Silaghi, C, et al. Candidatus Neoehrlichia mikurensis in rodents in an area with sympatric existence of the hard ticks Ixodes ricinus and Dermacentor reticulatus, Germany. Parasites and Vectors 2012; 5: 285.
41. Glatz, M, et al. Detection of Candidatus Neoehrlichia mikurensis, Borrelia burgdorferi sensu lato genospecies and Anaplasma phagocytophilum in a tick population from Austria. Ticks and Tick Borne Diseases 2014; 5: 139144.
42. Hornok, S, et al. First evidence of Candidatus Neoehrlichia mikurensis in Hungary. Parasites and Vectors 2013; 6: 267.
43. Rollend, L, Fish, D, Childs, JE. Transovarial transmission of Borrelia spirochetes by Ixodes scapularis: a summary of the literature and recent observations. Ticks and Tick Borne Diseases 2013; 4: 4651.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed