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Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern Australia

  • M. J. Lydeamore (a1) (a2), P. T. Campbell (a2) (a3), W. Cuningham (a3), R. M. Andrews (a4) (a5), T. Kearns (a4), D. Clucas (a6), R. Gundjirryirr Dhurrkay (a4), J. Carapetis (a7), S. Y. C. Tong (a5) (a8), J. M. McCaw (a1) (a2) (a3) (a9) and J. McVernon (a2) (a3) (a9)...
Abstract

Prevalence of skin sores and scabies in remote Australian Aboriginal communities remains unacceptably high, with Group A Streptococcus (GAS) the dominant pathogen. We aim to better understand the drivers of GAS transmission using mathematical models. To estimate the force of infection, we quantified the age of first skin sores and scabies infection by pooling historical data from three studies conducted across five remote Aboriginal communities for children born between 2001 and 2005. We estimated the age of the first infection using the Kaplan–Meier estimator; parametric exponential mixture model; and Cox proportional hazards. For skin sores, the mean age of the first infection was approximately 10 months and the median was 7 months, with some heterogeneity in median observed by the community. For scabies, the mean age of the first infection was approximately 9 months and the median was 8 months, with significant heterogeneity by the community and an enhanced risk for children born between October and December. The young age of the first infection with skin sores and scabies reflects the high disease burden in these communities.

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Corresponding author
Author for correspondence: J. McVernon, E-mail: j.mcvernon@unimelb.edu.au
References
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1.Australian Health Ministers’ Advisory Council (2014) Aboriginal and Torres Strait Islander Health Performance Framework 2014 Report.
2.Andrews, RM et al. (2009) A regional initiative to reduce skin infections amongst aboriginal children living in remote communities of the Northern Territory, Australia. PLoS Neglected Tropical Diseases 3, e554.
3.Carapetis, JR et al. (1997) Success of a scabies control program in an Australian Aboriginal community. The Pediatric Infectious Disease Journal 6, 494499.
4.La Vincente, S et al. (2009) Community management of endemic scabies in remote Aboriginal communities of northern Australia: low treatment uptake and high ongoing acquisition. PL0S Neglected Tropical Diseases 3, e444.
5.McDonald, MI et al. (2008) The dynamic nature of group A streptococcal epidemiology in tropical communities with high rates of rheumatic heart disease. Epidemiology and Infection 136, 529539.
6.Wong, LC et al. (2001) Outcome of an interventional program for scabies in an Indigenous community. The Medical Journal of Australia 175, 367370.
7.Romani, L et al. (2015) Prevalence of scabies and impetigo worldwide: a systematic review. The Lancet Infectious Diseases 15, 960967.
8.Bowen, AC et al. (2015) The global epidemiology of impetigo: a systematic review of the population prevalence of impetigo and pyoderma. PLoS ONE 10, e0136789.
9.Kearns, T et al. (2013) Clinic Attendances during the first 12 months of life for Aboriginal children in five remote communities of northern Australia. PLoS ONE 8, 15.
10.Clucas, DB et al. (2008) Disease burden and health-care clinic attendances for young children in remote Aboriginal communities of northern Australia. Bulletin of the World Health Organization 86, 275281.
11.Australia's health (2016) Australia's health series no. 15., Australian Institute of Health and Welfare 2016. Cat. no. AUS 199. Canberra: AIHW.
12.McMeniman, E et al. (2011) Skin disease in the first two years of life in Aboriginal children in East Arnhem Land. Australasian Journal of Dermatology 52, 270273.
13.Anderson, RM et al. (1992) Infectious Diseases of Humans: Dynamics and Control. Oxford University Press.
14.De Angelis, R et al. (1999) Mixture models for cancer survival analysis: application to population-based data with covariates. Statistics in Medicine 18, 441454.
15.Kermack, WO and McKendrick, AG (1927) A contribution to the mathematical theory of epidemics. Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences 115, 700721.
16.Kearns, TM et al. (2015) Impact of an ivermectin mass drug administration on scabies prevalence in a remote Australian aboriginal community. PLoS Neglected Tropical Diseases 9, e0004151.
17.Maddox, JS et al. (1985) The natural history of streptococcal skin infection: prevention with topical antibiotics. Journal of the American Academy of Dermatology 13, 207212.
18.Poon-King, T et al. (1967) Recurrent epidemic nephritis in South Trinidad. New England Journal of Medicine 277, 728733.
19.Dillon, HC (1968) Impetigo contagiosa: suppurative and Non-suppurative complications: I. clinical, bacteriologic, and epidemiologic characteristics of impetigo. American Journal of Diseases of Children 115, 530541.
20.Dajani, AS et al. (1972) Natural history of impetigo: II. Etiologic agents and bacterial interactions. Journal of Clinical Investigation 51, 28632871.
21.Anthony, BF et al. (1976) The dynamics of streptococcal infections in a defined population of children: serotypes associated with skin and respiratory infections. American Journal of Epidemiology 104, 652666.
22.Rycroft, RJG and Smith, WDL (1980) Low humidity occupational dermatoses. Contact Dermatitis 6, 488492.
23.Cox, DR (1992) Regression models and life-tables. In Samuel, Kotz and Johnson, Norman L. (eds). Breakthroughs in Statistics. New York, NY: Springer, pp. 527541.
24.Yeoh, DK et al. (2017) Are scabies and impetigo ‘normalised’? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections. PLOS Neglected Tropical Diseases 11, e0005726.
25.Gracey, M and King, M (2009) Indigenous health part 1: determinants and disease patterns. The Lancet 374, 6575.
26.Huffam, SE and Currie, BJ (1998) Ivermectin for Sarcoptes scabiei hyperinfestation. International Journal of Infectious Diseases 2, 152154.
27.Mounsey, KE et al. (2016) Prospects for moxidectin as a new oral treatment for human scabies. PLoS Neglected Tropical Diseases 10, e0004389.
28.Currie, BJ et al. (2004) First documentation of in vivo and in vitro ivermectin resistance in S arcoptes scabiei. Clinical Infectious Diseases 39, e8e12.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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