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Case-control study on Puumala virus infection: smoking is a risk factor

  • K. VAPALAHTI (a1) (a2), A.-M. VIRTALA (a3), A. VAHERI (a1) (a2) and O. VAPALAHTI (a1) (a2) (a3)
  • DOI: http://dx.doi.org/10.1017/S095026880999077X
  • Published online: 28 September 2009
Abstract
SUMMARY

Puumala hantavirus (PUUV) is apparently transmitted to humans by inhalation of aerosolized secretions of carrier rodents (bank voles). The means of transmission and the associated risk factors are poorly defined. An epidemiological study during the peak of an epidemic season in Finland was conducted based on 282 acute clinical PUUV infections and 204 controls without PUUV infection or immunity. The main risk factors adjusted by age, sex and living environment were cigarette smoking [odds ratio (OR) 3·6, 95% confidence interval (CI) 2·1–5·9, P<0·0001] and buildings with holes allowing rodents to enter (OR 3·3, 95% CI 2·0–5·6); these results were similar in two subsets. Further, use of rodent traps (OR3·5, 95% CI 2·2–5·7) and handling firewood (OR 2·7, 95% CI 1·6–4·4) were associated with a risk. The risk attributed to smoking also remained high using simulated population controls with average smoking habits. The results suggest that hantavirus transmission occurs by inhalation mainly indoors and is dependent on the condition of the respiratory tract.

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Corresponding author
*Author for correspondence: Dr O. Vapalahti, Haartman Institute, Department of Virology, P.O. Box 21 (Haartmaninkatu 3), FIN-00014University of Helsinki, Finland. (Email: olli.vapalahti@helsinki.fi)
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2.O Vapalahti , Hantaviruses in Europe. Lancet Infectious Diseases 2003; 3: 653661.

3.NS Crowcroft , Risk factors for human hantavirus infection: Franco-Belgian collaborative case-control study during 1995–6 epidemic. British Medical Journal 1999; 318: 17371738.

4.PS Zeitz , A case-control study of hantavirus pulmonary syndrome during an outbreak in the southwestern United States. Journal of Infectious Diseases 1995; 171: 864870.

5.ZY Xu , Epidemiological studies of hemorrhagic fever with renal syndrome: analysis of risk factors and mode of transmission. Journal of Infectious Diseases 1985; 152: 137144.

8.K Hedman , A Vaheri , M Brummer-Korvenkontio . Rapid diagnosis of hantavirus disease with an IgG-avidity assay. Lancet 1991; 338: 13531356.

9.O Vapalahti , Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response. Journal of Medical Virology 1995; 46: 293303.

11.H Kallio-Kokko , Evaluation of Puumala virus IgG and IgM enzyme immunoassays based on recombinant baculovirus-expressed nucleocapsid protein for early nephropathia epidemica diagnosis. Clinical and Diagnostic Virology 1998; 10: 8390.

12.MJ Raftery , Hantavirus infection of dendritic cells. Journal of Virology 2002; 76: 1072410733.

13.R Vassallo , Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. Journal of Immunology 2005; 175: 26842691.

14.JP Nuorti , Cigarette smoking and invasive pneumococcal disease. New England Journal of Medicine 2000; 342: 732734.

15.GE Olsson , Human hantavirus infections, Sweden. Emerging Infectious Diseases 2003; 9: 13951401.

16.K Vapalahti , Puumala virus infections in Finland: increased risk for farmers. American Journal of Epidemiology 1999; 149: 11421151.

17.C Ahlm , Prevalence of antibodies specific to Puumala virus among farmers in Sweden. Scandinavian Journal of Work Environment & Health 1998; 24: 104108.

18.F Van Loock , A case-control study after a hantavirus infection outbreak in the south of Belgium: who is at risk? Clinical Infectious Diseases 1999; 28: 834839.

19.SL Ruo , Retrospective and prospective studies of hemorrhagic fever with renal syndrome in rural China. Journal of Infectious Diseases 1994; 170: 527534.

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