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    Chen, Zhiyun Zhang, Jing Cao, Lina Zhang, Nan Zhu, Junping Ping, Guoling Zhao, Jianhong Li, Shuming and He, Qiushui 2016. Seroprevalence of pertussis among adults in China where whole cell vaccines have been used for 50 years. Journal of Infection, Vol. 73, Issue. 1, p. 38.

    Sedighi, Iraj Karimi, Abdollah and Amanati, Ali 2016. Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis. Iranian Journal of Pediatrics, Vol. 26, Issue. 4,

    Barkoff, Alex-Mikael Gröndahl-Yli-Hannuksela, Kirsi He, Qiushui and Carbonetti, Nicholas 2015. Seroprevalence studies of pertussis: what have we learned from different immunized populations. Pathogens and Disease, Vol. 73, Issue. 7, p. ftv050.


Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China

  • Y. WU (a1), B. ZHU (a1), Y. GAO (a1), Z. SHI (a2), J. WANG (a2), H. WANG (a2) and Z. SHAO (a1)
  • DOI:
  • Published online: 05 December 2013

In a large serosurvey performed in Gaobeidian city, China, 1032 children and adolescents aged 3–18 years were divided into three age groups: 3–6, 7–11, and 12–18 years. The geometric mean of IgG antibodies against pertussis toxin (anti-PT IgG) varied from 3·47 IU/ml (3–6 years) to 8·71 IU/ml (12–18 years) and the seroprevalence (⩾40 IU/ml) varied from 4·48% (7–11 years) to 11·76% (12–18 years). Infections were clustered in three secondary schools (schools 1–3). However, excluding secondary schools 1–3, the IgG PT levels, seroprevalence and rates of recent infections (>100 IU/ml) in secondary schools 4–7 (where infections were not clustered) were very close to those in the 3–6 and 7–11 years age groups. This suggests that the high seroprevalence and anti-PT IgG levels in adolescents in Gaobeidian city, China were caused by the clustered cases in certain secondary schools. Our results also suggested that pertussis was still circulating in China, and the reported incidence might be underestimated.

Corresponding author
*Author for correspondence: Dr Z. Shao, Changbai Road, Department of Respiratory Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Changping, Beijing, People's Republic of China. (Email:
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Epidemiology & Infection
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