Skip to main content
×
Home
    • Aa
    • Aa

Clustered cases of Bordetella pertussis infection cause high levels of IgG antibodies against pertussis toxin in adolescents in Gaobeidian city, China

  • Y. WU (a1), B. ZHU (a1), Y. GAO (a1), Z. SHI (a2), J. WANG (a2), H. WANG (a2) and Z. SHAO (a1)...
Summary
SUMMARY

In a large serosurvey performed in Gaobeidian city, China, 1032 children and adolescents aged 3–18 years were divided into three age groups: 3–6, 7–11, and 12–18 years. The geometric mean of IgG antibodies against pertussis toxin (anti-PT IgG) varied from 3·47 IU/ml (3–6 years) to 8·71 IU/ml (12–18 years) and the seroprevalence (⩾40 IU/ml) varied from 4·48% (7–11 years) to 11·76% (12–18 years). Infections were clustered in three secondary schools (schools 1–3). However, excluding secondary schools 1–3, the IgG PT levels, seroprevalence and rates of recent infections (>100 IU/ml) in secondary schools 4–7 (where infections were not clustered) were very close to those in the 3–6 and 7–11 years age groups. This suggests that the high seroprevalence and anti-PT IgG levels in adolescents in Gaobeidian city, China were caused by the clustered cases in certain secondary schools. Our results also suggested that pertussis was still circulating in China, and the reported incidence might be underestimated.

Copyright
Corresponding author
* Author for correspondence: Dr Z. Shao, Changbai Road, Department of Respiratory Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Changping, Beijing, People's Republic of China. (Email: shaozhujun@icdc.cn)
References
Hide All
1. ZeppF, et al. Rationale for pertussis booster vaccination throughout life in Europe. Lancet Infectious Diseases 2011; 11: 557570.
2. Pan American Health Organization. Final report of the XIX Technical Advisory Group (TAG) Meeting on Vaccine-preventable Diseases of the Pan American Health Organization, Buenos Aires, Argentina, July 2011 (http://new.paho.org/hq/index.php?option=com_content&view=article&id=1862&Itemid=1674).
3. CherryJ. Epidemic pertussis in 2012 – the resurgence of a vaccine-preventable disease. New England Journal of Medicine 2012; 367: 785787.
4. SkowronskiDM, et al. The changing age and seasonal profile of pertussis in Canada. Journal of Infection 2002; 185: 1696.
5. TorresJ, et al. Outbreak of whooping cough with a high attack rate in well-vaccinated children and adolescents. Enfermedades Infecciosas y Microbiología Clínica 2011; 29: 564567.
6. MelkerHE, et al. Re-emergence of pertussis in the highly vaccinated population of the Netherlands: observations on surveillance data. Emerging Infectious Diseases 2000; 6: 348357.
7. MinkC, et al. Outbreak of pertussis in a fully immunized adolescent and adult population. Clinical Infectious Diseases 1992; 14: 464471.
8. World Health Organization. Pertussis surveillance, a global meeting, Geneva, 16–18 October 2000 (2001). Departments of Vaccines and Biologicals. Geneva: World Health Organization, WHO/V&B/01.19.
9. MossongJ, et al. Seroepidemiology of diphtheria and pertussis in Luxembourg I 2000. Epidemiology and Infection 2006; 134: 573578.
10. YihW, et al. The increasing incidence of pertussis in Massachusetts adolescents and adults, 1989–1998. Journal of Infectious Diseases 2000; 182: 1409–16.
11. GreenbergDP. Pertussis in adolescents: increasing incidence brings attention to the need for booster immunization of adolescents. Pediatric Infectious Disease 2005; 24: 721728.
12. World Health Organization. Immunization profile – China, 2010.
13. QiZ, et al. The seroepidemiology of immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study. BMC Infectious Diseases 2012; 12: 138.
14. OuJ, et al. History and progress on the research of pertussis in china review. Journal of Clinical Pediatrics 2007; 25: 607609.
15. FuJ, et al. Analysis on pertussis epidemiology in Zhejiang province in 1954–2004. Chinese Journal of Vaccines and Immunization 2005; 11: 279281.
16. YanY, et al. Analysis on epidemiology in 1963–2002 and control strategy on pertussis in Henan province. Chinese Journal of Vaccines and Immunization 2005; 11: 402404.
17. MullerF, et al. Laboratory diagnosis of pertussis: state of the art in 1997. Journal of Clinical Microbiology 1997; 35: 24352443.
18. VersteeghF, et al. Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Boerderella pertussis . Epidemiology and Infection 2005; 133: 737748.
19. HallanderHO, et al. Kinetics and sensitivity of ELISA IgG pertussis antitoxin after infection and vaccination with bordetella pertussis in young children. APMIS 2009; 117: 797807.
20. HorbyP, et al. A boarding school outbreak of pertussis in adolescents: value of laboratory diagnostic methods. Epidemiology and Infection 2005; 133: 229236.
21. DuranogluL, et al. Evaluation of pertussis immunity status in schoolchildren immunized with whole-cell vaccine. Epidemiology and Infection 2010; 138: 299303.
22. MelkerH, et al. Specificity and sensitivity of high levels of immunoglobulin G antibodies against pertussis toxin in a single serum sample for diagnosis of infection with bordetella pertussis. Journal of Clinical Microbiology 2000; 38: 800806.
23. HallanderH, et al. Seroprevalence of pertussis antitoxin (anti-PT) in Sweden before and 10 years after the introduction of a universal childhood pertussis vaccination program. APMIS 2009; 117: 912922.
24. CherryJD, et al. Defining pertussis epidemiology, clinical, microbiologic and serologic perspectives. Pediatric Infectious Disease Journal 2005; 24: s25s34.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 9 *
Loading metrics...

Abstract views

Total abstract views: 112 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st October 2017. This data will be updated every 24 hours.