Hostname: page-component-5d59c44645-l48q4 Total loading time: 0 Render date: 2024-02-28T01:49:52.315Z Has data issue: false hasContentIssue false

Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases

Published online by Cambridge University Press:  01 October 1998

C. IRIBARREN
Affiliation:
Kaiser Permanente Division of Research, Oakland, CA, USA
D. R. JACOBS
Affiliation:
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
S. SIDNEY
Affiliation:
Kaiser Permanente Division of Research, Oakland, CA, USA
A. J. CLAXTON
Affiliation:
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
K. R. FEINGOLD
Affiliation:
Metabolism Section (111F), Department of Veterans Affairs Medical Center, San Francisco, CA, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A multiethnic cohort of adult members of the Kaiser Permanente Medical Care Program (55300 men and 65271 women) was followed for 15 years (1979–93) to assess the association between total cholesterol and risk of infections (other than respiratory and HIV) diagnosed in the in-patient setting. Using multivariate Cox regression, total cholesterol was inversely and significantly related to urinary tract, venereal, musculo-skeletal, and all infections among men; and to urinary tract, all genito-urinary, septicaemia or bacteraemia, miscellaneous viral site unspecified, and all infections among women. The reduction of risk of all infections associated with a 1 s.d. increase in total cholesterol was 8% in both men (95% CI, 4–12%) and women (95% CI, 5–11%). For urinary tract infections among men, as for septicaemia or bacteraemia and nervous system infections among women, the risk relation was restricted to persons aged 55–89 years. Nervous system infections were positively related to total cholesterol among women aged 25–54. In both genders, the significant inverse association with all infections persisted after excluding the first 5 years of follow-up. Collectively, these data are suggestive of an inverse association, although not entirely consistent, between total cholesterol and incidence of infections either requiring hospitalization or acquired in the hospital. Further research is needed to elucidate whether these associations are biologically plausible or represent uncontrolled confounding by unmeasured risk factors.

Type
Research Article
Copyright
© 1998 Cambridge University Press