Skip to main content
×
Home
    • Aa
    • Aa

Cost-effectiveness of influenza control measures: a dynamic transmission model-based analysis

  • S.-C. CHEN (a1) (a2) and C.-M. LIAO (a3)
Summary
SUMMARY

We investigated the cost-effectiveness of different influenza control strategies in a school setting in Taiwan. A susceptible-exposure-infected-recovery (SEIR) model was used to simulate influenza transmission and we used a basic reproduction number (R0)–asymptomatic proportion (θ) control scheme to develop a cost-effectiveness model. Based on our dynamic transmission model and economic evaluation, this study indicated that the optimal cost-effective strategy for all modelling scenarios was a combination of natural ventilation and respiratory masking. The estimated costs were US$10/year per person in winter for one kindergarten student. The cost for hand washing was estimated to be US$32/year per person, which was much lower than that of isolation (US$55/year per person) and vaccination (US$86/year per person) in containing seasonal influenza. Transmission model-based, cost-effectiveness analysis can be a useful tool for providing insight into the impacts of economic factors and health benefits on certain strategies for controlling seasonal influenza.

Copyright
Corresponding author
*Author for correspondence: Dr S.-C. Chen, Department of Public Health, Chung Shan Medical University, Taichung, Taiwan 40201, ROC. (Email: scchen@csmu.edu.tw)
References
Hide All
2. BJ Ridenhour , Controlling the spread of disease in schools. PLoS One 2011; 6: e29640.

3. CM Liao , CF Chang , HM Liang . A probabilistic transmission dynamic model to assess indoor airborne infection risks. Risk Analysis 2005; 25: 10971107.

4. SC Chen , CF Chang , CM Liao . Predictive models of control strategies involved in containing indoor airborne infections. Indoor Air 2006; 16: 469481.

5. SC Chen , CM Liao . Modelling control measures to reduce the impact of pandemic influenza among schoolchildren. Epidemiology and Infection 2008; 136: 10351045.

8. RM Anderson , RM May . Infectious Diseases of Humans: Dynamics and Control. UK: Oxford University Press, 1991.

9. R Brookmeyer , E Johnson , R Bollinger . Modeling the optimum duration of antibiotic prophylaxis in an anthrax outbreak. Proceedings of the National Academy of Sciences USA 2003; 100: 1012910132.

10. R Brookmeyer , E Johnson , R Bollinger . Public health vaccination policies for containing an anthrax outbreak. Nature 2004; 432: 901904.

11. R Brookmeyer , E Johnson , S Barry . Modeling the incubation period of anthrax. Statistics in Medicine 2005; 24: 531542.

12. EA Nardell , Airborne infection: theoretical limits of protection achievable by building ventilation. American Review of Respiratory Disease 1991; 144: 302306.

13. S Barnhart , Tuberculosis in health care settings and the estimated benefits of engineering controls and respiratory protection. Journal of Occupational and Environmental Medicine 1997; 39: 849854.

14. SN Rudnick , DK Milton . Risk of indoor airborne infection transmission estimated from carbon dioxide concentration. Indoor Air 2003; 13: 237245.

15. M Baguelin , Health and economic impact of the seasonal influenza vaccination programme in England. Vaccine 2012; 30: 34593462.

16. RP Velasco , Systematic review of economic evaluations of preparedness strategies and interventions against influenza pandemics. PLoS One 2012; 7: e30333.

17. L Acedo , Cost analysis of a vaccination strategy for respiratory syncytial virus (RSV) in a network model. Mathematical and Computer Modelling 2010; 52: 10161022.

18. ST Brown , Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost?: a computational simulation of Pennsylvania. BMC Public Health 2011; 11: 353.

19. CS Wang , ST Wang , P Chou . Efficacy and cost-effectiveness of influenza vaccination of the elderly in a densely populated and unvaccinated community. Vaccine 2002; 20: 24942499.

20. ST Wang , Economic evaluation of vaccination against influenza in the elderly: an experience from a population-based influenza vaccination program in Taiwan. Vaccine 2005; 23: 19731980.

21. WJ Edmunds , GF Medley , DJ Nokes . Evaluating the cost-effectiveness of vaccination programmes: A dynamic perspective. Statistics in Medicine 1999; 18: 32633282.

22. PJ Neumann , AB Rosen , MC Weinstein . Medicare and cost-effectiveness analysis. New England Journal of Medicine 2005; 353: 15161522.

23. C Fraser , Factors that make an infectious disease outbreak controllable. Proceedings of the National Academy of Sciences USA 2004; 101: 61466151.

24. CB Beggs , Methodology for determining the susceptibility of airborne microorganisms to irradiation by an upper-room UVGI system. Journal of Aerosol Science 2006; 37: 885902.

25. MV Maciosek , Influenza vaccination: health impact and cost effectiveness among adults aged 50 to 64 and 65 and older. American Journal of Preventive Medicine 2006; 31: 7279.

26. S Aballea , The cost effectiveness of influenza vaccination for adults aged 50 to 64 years: a model-based analysis for Spain. Vaccine 2007; 25: 69006910.

27. SL Hoshi , Cost-effectiveness analysis of influenza vaccination for people aged 65 and over in Japan. Vaccine 2007; 25: 65116521.

28. D Weycker , Population-wide benefits of routine vaccination of children against influenza. Vaccine 2005; 23: 12841293.

29. LA Prosser , Health benefits, risks, and cost-effectiveness of influenza vaccination of children. Emerging Infectious Diseases 2006; 12: 15481558.

31. L Salleras , Effectiveness of virosomal subunit influenza vaccine in preventing influenza-related illnesses and its social and economic consequences in children aged 3–14 years: a prospective cohort study. Vaccine 2006; 24: 66386642.

35. JP Niffenegger . Proper handwashing promotes wellness in child care. Journal of Pediatric Health Care 1997; 11: 2631.

36. MG Roberts , MI Tobias . Predicting and preventing measles epidemics in New Zealand: application of mathematical model. Epidemiology and Infection 2000; 124: 279287.

37. MA Ryan , RS Christian , J Wohlrabe . Handwashing and respiratory illness among young adults in military training. American Journal of Preventive Medicine 2001; 21: 7983.

38. CG White , Reduction of illness absenteeism in elementary schools using an alcohol-free instant hand sanitizer. Journal of School Nursing 2001; 17: 258265.

39. C White , The effect of hand hygiene on illness rate among students in university residence halls. American Journal of Infection Control 2003; 31: 364370.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 3
Total number of PDF views: 38 *
Loading metrics...

Abstract views

Total abstract views: 194 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 16th October 2017. This data will be updated every 24 hours.