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Decreased prevalence and age-specific risk factors for Toxoplasma gondii IgG antibodies in The Netherlands between 1995/1996 and 2006/2007

  • A. HOFHUIS (a1), W. VAN PELT (a1), Y. T. H. P. VAN DUYNHOVEN (a2), C. D. M. NIJHUIS (a3), L. MOLLEMA (a1), F. R. M. VAN DER KLIS (a3), A. H. HAVELAAR (a2) (a4) and L. M. KORTBEEK (a3)...
Summary
SUMMARY

To estimate the change in the seroprevalence and risk factors for toxoplasmosis in The Netherlands, a study was conducted in the general population in 2006/2007, similarly designed as a previous study in 1995/1996. Testing 5541 sera for IgG antibodies against Toxoplasma gondii showed a marked decrease of the overall seroprevalence to 26·0% [95% confidence interval (CI) 24·0–28·0], compared to 40·5% (95% CI 37·5–43·4) in 1995/1996. In women of reproductive age the seroprevalence decreased from 35·2% (95% CI 32·9–38·6) in 1995/1996 to 18·5% (95% CI 16·2–20·7) in 2006/2007, leaving the majority of pregnant women susceptible to primary infection with T. gondii and their babies to congenital toxoplasmosis. In participants aged ⩾20 years, Toxoplasma seropositivity was associated with living in the Northwest, living in urban areas, low educational level, consumption of raw pork, keeping a cat, and not having occupational contact with clients or patients. For younger participants, risk factors were keeping sheep or cattle, consumption of raw unwashed vegetables and putting sand in the mouth.

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Corresponding author
*Author for correspondence: Drs. L. M. Kortbeek, National Institute for Public Health and the Environment, Center for Infectious Disease Control, PO Box 1, 3720 BA Bilthoven, The Netherlands. (Email: Titia.Kortbeek@rivm.nl)
References
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1.Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. International Journal of Parasitology 2000; 30: 12171258.
2.Hill D, Dubey JP. Toxoplasma gondii: transmission, diagnosis and prevention. Clinical Microbiology and Infection 2002; 8: 634640.
3.Weiss LM, Dubey JP. Toxoplasmosis: a history of clinical observations. International Journal of Parasitology 2009; 39: 895901.
4.Gilbert RE, et al. Incidence of symptomatic toxoplasma eye disease: aetiology and public health implications. Epidemiology and Infection 1999; 123: 283289.
5.Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004; 363: 19651976.
6.Berger F, et al. Toxoplasmosis among pregnant women in France: Risk factors and change of prevalence between 1995 and 2003. Revue d Épidémiologie et de Santé Publique 2009; 57: 241248.
7.Nash JQ, et al. Risk factors for toxoplasmosis in pregnant women in Kent, United Kingdom. Epidemiology and Infection 2005; 133: 475483.
8.Lebech M, et al. Feasibility of neonatal screening for toxoplasma infection in the absence of prenatal treatment. Lancet 1999; 353: 18341837.
9.Evengård B, et al. Low incidence of toxoplasma infection during pregnancy and in newborns in Sweden. Epidemiology and Infection 2001; 127: 121127.
10.Pappas G, Roussos N, Falagas ME. Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. International Journal of Parasitology 2009; 39: 13851394.
11.Conyn-van Spaendonck MAE.Prevention of congenital toxoplasmosis in The Netherlands (thesis). Rotterdam, The Netherlands: Erasmus University, 1991.
12.Kortbeek LM, et al. Population-based Toxoplasma seroprevalence study in The Netherlands. Epidemiology and Infection 2004; 132: 839845.
13.De Melker HE, Conyn-van Spaendonck MA. Immunosurveillance and the evaluation of national immunization programmes: a population-based approach. Epidemiology and Infection 1998; 121: 637643.
14.De Melker HE, Nagelkerde NJ, Conyn-van Spaendonck MA. Non-participation in a population-based seroprevalence study of vaccine-preventable diseases. Epidemiology and Infection 2000; 124: 255262.
15.van der Klis FRM, et al. Second national serum bank for population-based seroprevalence studies in the Netherlands. The Netherlands Journal of Medicine 2009; 67: 301308.
16.Ruitenberg EJ, van Knapen F. The enzyme-linked immunosorbent assay and its application to parasitic infections. Journal of Infectious Diseases 1977; 136 (Suppl.): S267S273.
17.Ramsay JO. Monotone regression splines in action. Statistical Science 1988; 3: 425461.
18.Gilbert R, Gras L; European Multicentre Study on Congenital Toxoplasmosis. Effect of timing and type of treatment on the risk of mother to child transmission of Toxoplasma gondii. British Journal of Obstetrics and Gynecology 2003; 110: 112120.
19.Dunn D, et al. Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet 1999; 353: 18291833.
20.Kijlstra A, Jongert E. Control of the risk of human toxoplasmosis transmitted by meat. International Journal of Parasitology 2008; 38: 13591370.
21.Dubey JP, Jones JL. Toxoplasma gondii infection in humans and animals in the United States. International Journal of Parasitology 2008; 38: 12571278.
22.Bénard A, et al. European Toxo Prevention Study Group (EUROTOXO). Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis. Eurosurveillance 2008; 13(15).
23.Bénard A, Salmi LR, Mouillet E, for Panel 1 the Eurotoxo Group. Systematic review on the burden of congenital toxoplasmosis in Europe (unpublished report). Bordeaux (France): The EUROTOXO Group, 2005.
24.Cook AJ, et al. Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. British Medical Journal 2000; 321: 142147.
25.Leroy V, Hadjichristodoulou C, for the Eurotoxo Group (panel 3). Systematic review of risk factors for Toxoplasma gondii infection in pregnant women (unpublished report). Bordeaux (France): The EUROTOXO Group, September 2005.
26.Kortbeek LM, et al. Congenital toxoplasmosis and DALYs in the Netherlands. Memórias do Instituto Oswaldo Cruz 2009; 104: 370373.
27.Kapperud G, et al. Risk factors for Toxoplasma gondii infection in pregnancy. Results of a prospective case-control study in Norway. American Journal of Epidemiology 1996; 144: 405412.
28.van der Giessen J, et al. Seroprevalence of Trichinella spiralis and Toxoplasma gondii in pigs from different housing systems in The Netherlands. Veterinarian Parasitology 2007; 148: 371374.
29.Jones JL, et al. Risk factors for Toxoplasma gondii infection in the United States. Clinical Infectious Diseases 2009; 49: 878884.
30.Dubey JP. Duration of immunity to shedding of Toxoplasma gondii oocysts by cats. Journal of Parasitology 1995; 81: 410415.
31.Davis SW, Dubey JP. Mediation of immunity to Toxoplasma gondii oocyst shedding in cats. Journal of Parasitology 1995; 81: 882886.
32.Kniel KE, et al. Examination of attachment and survival of Toxoplasma gondii oocysts on raspberries and blueberries. Journal of Parasitology 2002; 88: 790793.
33.Baril L, et al. Risk factors for Toxoplasma infection in pregnancy: a case-control study in France. Scandinavian Journal of Infectious Diseases 1999; 31: 305309.
34.Matsuo J, Nakashio S. Prevalence of fecal contamination in sandpits in public parks in Sapporo City, Japan. Veterinary Parasitology 2005; 128: 115119.
35.Doorduyn Y, et al. Risk factors for Salmonella Enteritidis and Typhimurium (DT104 and non-DT104) infections in The Netherlands: predominant roles for raw eggs in Enteritidis and sandboxes in Typhimurium infections. Epidemiology and Infection 2006; 134: 617626.
36.Werber D, et al. Shiga toxin-producing Escherichia coli infection in Germany: different risk factors for different age groups. American Journal of Epidemiology 2007; 165: 425434.
37.Lass A, et al. Detection of Toxoplasma gondii oocysts in environmental soil samples using molecular methods. European Journal of Clinical Microbiology and Infectious Diseases 2009; 28: 599605.
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