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Determination of colonization resistance of the digestive tract by biotyping of Enterobacteriaceae

  • H. Z. Apperloo-Renkema (a1), B. D. Van der Waaij (a1) and D. Van der Waaij (a1)

In studies concerning the effect of antibiotics on faecal microflora, Colonization Resistance is an important parameter. Colonization Resistance correlates inversely with the number of different biotypes of Enterobacteriaceae isolated from faecal samples. Nine healthy volunteers were studied during 6 weeks, in order to determine the natural variation in the number of different biotypes of Enterobacteriaceae per faecal sample. The numbers of biotypes ranged from 1–15 per faecal sample, the mean number of biotypes varied between 2·6 and 7·3 different biotypes per faecal sample per healthy volunteer. Inter-individual variations of five biotypes in the mean number of biotypes per faecal sample are normal. We assessed the minimal number of faecal samples that should be taken for comprehensive biotyping so as to determine reliably the mean number of different biotypes representative for the Colonization Resistance of an individual. It was found that a minimum of four faecal samples was required.

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9. DM Hahn , SC Schimpff , CL Fortner , AC Smyth , VM Young , PH Wiernik . Infection in acute leukemia patients receiving oral nonabsorbable antibiotics. Antimicrob Agents Chemother 1978: 13: 958–64.

10. D van der Waaij , TM Tieleman-Speltie , AMJ De Roeck-Houben . Infection by and distribution of biotypes of Enterobacteriaceae species in leukaemic patients treated under ward conditions and in units for protective isolation in seven hospitals in Europe. Infection 1977; 5: 188–94.

11. D van der Waaij , TM Tieleman-Speltie , AMJ De Roeck-Houben . Relation between the faecal concentration of various potentially pathogenic microorganisms and infections in individuals (mice) with severely decreased resistance to infection. Antonie van Leeuwenhoek 1978; 44: 395405.

12. CH Tancrède . AO Andremont . Bacterial translocation and gramnegative bacteremia in patients with hematological malignancies. J Infect Dis 1985; 152: 99103.

13. SC Schimpff , VM Young , WH Greene , GD Vermeulen . MR Moody . PH Wiernik . Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med 1972; 77: 707–14.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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