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The development and evaluation of a μ-capture ELISA detecting chlamydia-specific Igm

  • T. G. Wreghitt (a1), V. J. Robinson (a2), E. O Caul (a3), I. D. Paul (a3) and S. Gatley (a4)...

A μ-capture enzyme-linked immunosorbent assay (ELISA) for detecting chlamydia-specific IgM was developed by use of the heat stable, lipopolysaccharide group-specific antigen and an alkaline phosphatase-labelled anti-chlamydia group-specific monoclonal antibody conjugate. The test was used to study the serological response in chlamydial respiratory tract infection among patients with acute respiratory tract symptoms in Cambridgeshire during the past 7 years. Results were compared with those of the complement fixation test (CFT) in routine use as well as those of a whole inclusion indirect immunofluorescence (WIF) test for IgM. Correlation between results of the μ-capture ELISA and those of the WIF test was 87·5%.

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J. T. Grayston , C. C. Kuo , S. Wang & J. Altman (1986). A new Chalamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. New England Journal of Medicine 315, 161168.

J. Schachter , L. Lum , C. A. Gooding & B. Ostler (1975). Pneumonitis following inclusion blennorhea. Journal of Pediatrics 87, 779780.

J. Strauss (1967). Microbiologic and epidemiologic aspects of duck ornithosis in Czechoslovakia. American Journal of Opthalmology 63, 12461259.

P. Terho & O. Meurman (1981). Chlamydial serum IgG, IgA and local IgA antibodies in patients with genital-tract infections, measured by solid-phase radioimmunoassay. Journal of Medical Microbiology 14, 7787.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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