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Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses

Published online by Cambridge University Press:  15 May 2009

T. Yoshii  and
R. Kono
T. Yoshii
Affiliation:
Central Virus Diagnostic Laboratory, National Institute of Health, Nakato, Musashimurayama-shi, Tokyo 190-12, Japan
R. Kono
Affiliation:
Central Virus Diagnostic Laboratory, National Institute of Health, Nakato, Musashimurayama-shi, Tokyo 190-12, Japan
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Replication of vaccinia and monkeypox viruses was impeded in the presence of 5-bromodeoxyuridine (BUdR) in RL-33 cells derived from rabbit lung tissue. The different degree of inhibition was found among strains of those viruses, in which it was evident that five strains (CV-1, Lister, IHD, Dairen-I and Ikeda) of vaccinia viruses resulted in more reduced yields of infectious virus than four strains (Sen-19, Orang Utan, Copenhagen and Sierra Leone) of monkeypox viruses. There was also strain variation in BUdR sensitivity within vaccinia viruses but not in the case of monkeypox viruses.

Information

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 2 , October 1978 , pp. 171 - 177
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Arita, I. & Henderson, D. A. (1968). Smallpox and monkeypox in non-human primates. Bulletin of the World Health Organization 39, 277–83.Google ScholarPubMed
Bourke, A. T. C. & Dumbell, K. R. (1972). An unusual poxvirus from Nigeria. Bulletin of the World Health Organization 46, 621–3.Google ScholarPubMed
Easterbrook, K. B. & Davern, C. I. (1963). The effect of 5-bromodeoxyuridine on the multiplication of vaccinia virus. Virology 19, 509–20.CrossRefGoogle Scholar
Gispen, R., Verlinde, J. D. & Zwart, P. (1967). Histopathological and virological studies on monkeypox. Archiv. für die gesamte Virusforschung 21, 205–16.CrossRefGoogle ScholarPubMed
Gispen, R. & Brand-Saathof, B. (1972). ‘White’ poxvirus strains from monkeys. Bulletin of the World Health Organization 46, 585–92.Google ScholarPubMed
Gispen, R. & Brand-Saathof, B. (1974). Three specific antigens produced in vaccinia, variola, and monkeypox infections. Journal of Infectious Diseases 129, 289–95.CrossRefGoogle ScholarPubMed
Lourie, B., Bingham, P. G., Evans, H. H., Foster, S. O., Nakano, J. H. & Herrmann, K. L. (1972). Human infection with monkeypox virus: laboratory investigation of six cases in West Africa. Bulletin of the World Health Organization 46, 633–9.Google ScholarPubMed
Magnus, P., Von, Anderson, E. K., Peterson, K. B. & Anderson, A. B. (1959). A pox-like disease in cynomolgus monkeys. Acta Pathologica et Microbiologica Scandinavica 46, 156–76.CrossRefGoogle Scholar
Marennikova, S. S., Seluhina, E. M., Mal'ceva, N. N., Cimiskjan, K. L. & Macevic, G. R. (1972). Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man. Bulletin of the World Health Organization 46, 599–611.Google ScholarPubMed
Sambrook, J. F., Padgett, B. L. & Tomkins, J. K. N. (1966). Conditional lethal mutants of rabbitpox virus. I. Isolation of host cell-dependent and temperature-dependent mutants. Virology 28, 592–9.CrossRefGoogle ScholarPubMed
Wilson, J. N. & Cooper, P. D. (1965). The effect of light on poliovirus grown in neutral red. Virology 26, 1–9.CrossRefGoogle ScholarPubMed
Yoshii, T. & Kono, R. (1977). Establishment of a rabbit lung cell line (RL-33) and its viral susceptibility. Japanese Journal of Medical Science and Biology 30, 149–57.CrossRefGoogle ScholarPubMed