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Differential inhibitory effects of 5-bromodeoxyuridine on vaccinia and monkeypox viruses

Published online by Cambridge University Press:  15 May 2009

T. Yoshii  and
R. Kono
T. Yoshii
Affiliation:
Central Virus Diagnostic Laboratory, National Institute of Health, Nakato, Musashimurayama-shi, Tokyo 190-12, Japan
R. Kono
Affiliation:
Central Virus Diagnostic Laboratory, National Institute of Health, Nakato, Musashimurayama-shi, Tokyo 190-12, Japan
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Summary

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Replication of vaccinia and monkeypox viruses was impeded in the presence of 5-bromodeoxyuridine (BUdR) in RL-33 cells derived from rabbit lung tissue. The different degree of inhibition was found among strains of those viruses, in which it was evident that five strains (CV-1, Lister, IHD, Dairen-I and Ikeda) of vaccinia viruses resulted in more reduced yields of infectious virus than four strains (Sen-19, Orang Utan, Copenhagen and Sierra Leone) of monkeypox viruses. There was also strain variation in BUdR sensitivity within vaccinia viruses but not in the case of monkeypox viruses.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 2 , October 1978 , pp. 171 - 177
Copyright
Copyright © Cambridge University Press 1978

References

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