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Methicillin-resistant Staphylococcus aureus colonization in HIV-infected outpatients is common and detection is enhanced by groin culture

  • P. J. PETERS (a1), J. T. BROOKS (a1), B. LIMBAGO (a1), H. K. LOWERY (a2), S. K. McALLISTER (a1), R. MINDLEY (a2), G. FOSHEIM (a1), R. J. GORWITZ (a1), J. L. GUEST (a2), J. HAGEMAN (a1), J. FRIDGE (a2) and D. RIMLAND (a2) (a3)...
Abstract
SUMMARY

Although high rates of clinical infection with methicillin-resistant Staphylococcus aureus (MRSA) have been reported in HIV-infected adults, data on MRSA colonization are limited. We enrolled HIV-infected adults receiving care at the Atlanta VA Medical Center. Swabs from each participant's nares and groin were cultured with broth enrichment for S. aureus. Of 600 HIV-infected adults, 79 (13%) were colonized with MRSA and 180 (30%) with methicillin-susceptible S. aureus. MRSA pulsed-field gel electrophoresis types USA300 (n=44, 54%) and USA500/Iberian (n=29, 35%) predominated. Inclusion of groin swabs increased MRSA detection by 24% and USA300 detection by 38%. In multivariate analysis, MRSA colonization compared to no MRSA colonization was associated with a history of MRSA clinical infection, rarely or never using condoms, and contact with prisons and jails. In summary, the prevalence of MRSA colonization was high in this study of HIV-infected adults and detection of USA300 was enhanced by groin culture.

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Corresponding author
*Author for correspondence: P. J. Peters, M.D., Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop E-45, Atlanta, GA 30333, USA. (Email: pjpeters@cdc.gov)
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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