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Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

  • N. Yamane (a1) and H. Uemura (a1)

The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10–16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to Fl allergen rose significantly in a considerable number of the vaccinccs. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

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R. Davies & J. Pepys (1976). Egg allergy, influenza vaccine, and immunoglobulin-E antibody. Journal of Allergy and Clinical Immunology 57, 373378.

T. Francis Jr (1967). Epidemic influenza: immunization and control. Medical Clinics of North America 51, 781790.

S. Hosoi , K. Shinomiya , H. Nakano , H. Mikawa & S. Harada (1985). Monoclonal antihuman IgG antibodies for quantitation of allergen-specific IgG in human sera. Journal of Allergy and Clinical Immunology 75, 320327.

K. Ishizaka & T. Ishizaka (1968). Human reaginic antibodies and immunoglobulin E. Journal of Allergy 42, 330363.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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