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Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization

Published online by Cambridge University Press:  19 October 2009

N. Yamane  and
H. Uemura
N. Yamane
Affiliation:
Department of Laboratory Medicine, Kumamoto University Medical School, 1-1-1, Honjo, Kumamoto 860, Japan
H. Uemura
Affiliation:
Department of Laboratory Medicine, Kumamoto University Medical School, 1-1-1, Honjo, Kumamoto 860, Japan
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Summary

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The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10–16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (Fl) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to Fl allergen rose significantly in a considerable number of the vaccinccs. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

Type
Research Article
Information
Epidemiology & Infection , Volume 100 , Issue 2 , April 1988 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 1988

References

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