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Does chloramphenicol remain the drug of choice for typhoid?

  • B. Rowe (a1), E. J. Threlfall (a1) and L. R. Ward (a1)

Of 2356 strains of Salmonella typhi isolated in Britain in the 8-year period 1978–85, 2345 (99·53%) were sensitive to all antibiotics tested and 11 (0·47%) were chloramphenicol-resistant; chloramphenicol resistance was plasmid-mediated in 6 strains. It is concluded that chloramphenicol remains a satisfactory first-line choice of drug for tyrphoid fever in Britain.

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H. C. Birnboim & J. Doly (1979). A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acid Research 7, 15131523.

A. B. Christie (1980). Typhoid and paratyphoid fevers. In Injections Diseases: Epidemiology and Clinical Practice, 3rd ednEdinburgh, London, Melbourne, New York: Churchill Livingstone.

W. E. Farrar (1985). Antibiotic resistance in developing countries. Journal of Infectious Diseases 152, 11031106.

C. K. J. Paniker & K. N. Vimala (1972). Transferable chloramphenicol resistance in Salmonella typhi. Nature, London 239, 109110.

K. B. Sharma , M. B. Bhat , A. Pasricha & E. Vaze (1979). Multiple antibiotic resistance among salmonellae in India. Journal of Antimicrobial Chemotherapy 5, 1521.

D. E. Taylor , J. C. Chumpitaz & F. Goldstein (1985). Variability of Inc Hn plasmids from Salmonella typhi with special reference to Peruvian plasmids encoding resistance to trimethoprim and other antibiotics. Antimicrobial Agents and Chemotherapy 28, 452455.

T.-Y. Ti , E. H. Monteiro , S. Lam & H.-S. Lee (1985). Ceftriaxone therapy in bacteremic typhoid fever. Antimicrobial Agents and Chemotherapy 28, 540543.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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