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Does chloramphenicol remain the drug of choice for typhoid?

  • B. Rowe (a1), E. J. Threlfall (a1) and L. R. Ward (a1)
  • DOI:
  • Published online: 19 October 2009

Of 2356 strains of Salmonella typhi isolated in Britain in the 8-year period 1978–85, 2345 (99·53%) were sensitive to all antibiotics tested and 11 (0·47%) were chloramphenicol-resistant; chloramphenicol resistance was plasmid-mediated in 6 strains. It is concluded that chloramphenicol remains a satisfactory first-line choice of drug for tyrphoid fever in Britain.

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