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Effects of ceftriaxone on faecal flora: analysis by micromorphometry

Published online by Cambridge University Press:  19 October 2009

B. C. Meijer ,
G. J. Kootstra ,
D. G. Geertsma  and
M. H. F. Wilkinson
B. C. Meijer
Affiliation:
Laboratory for Medical Microbiology, State University, Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
G. J. Kootstra
Affiliation:
Laboratory for Medical Microbiology, State University, Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
D. G. Geertsma
Affiliation:
Laboratory for Medical Microbiology, State University, Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
M. H. F. Wilkinson
Affiliation:
Laboratory for Medical Microbiology, State University, Groningen, Oostersingel 59, 9713 EZ Groningen, The Netherlands
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Summary

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In order to elucidate the effect of ceftriaxone therapy on the morphology of gut microflora, 11 human volunteers were treated with ceftriaxone, 1 g daily, given intramuscularly in one dose. Treatment continued for 5 days. Faecal microflora was analysed by digital image processing before, during and after the treatment period.

We derived simple numerical parameters which describe the morphologic composition of the flora. They were significantly influenced by the antibiotic, and returned to their baseline values more than 7 days after treatment was stopped. The procedure holds promise for clinical application.

Type
Research Article
Information
Epidemiology & Infection , Volume 106 , Issue 3 , June 1991 , pp. 513 - 521
Copyright
Copyright © Cambridge University Press 1991

References

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