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Emergence of increasing linezolid-resistance in enterococci in a post-outbreak situation with vancomycin-resistant Enterococcus faecium

  • B. SCHULTE (a1), A. HEININGER (a2), I. B. AUTENRIETH (a1) and C. WOLZ (a1)
Summary
SUMMARY

During 2004 and at the start of 2005 a university hospital in Southwest Germany was affected by an extensive outbreak of vancomycin-resistant Enterococcus faecium (VRE). Although the outbreak was contained, linezolid-resistant enterococci emerged during and after the outbreak as the usage of linezolid became more common. Linezolid resistance was no longer limited to VRE. Nosocomial spread of linezolid-resistant but vancomycin-susceptible E. faecium was detected and these strains also emerged in patients without prior drug exposure. Linezolid should therefore be used with caution and the susceptibility of isolates monitored over time. Isolation precautions and screening of contacts should be considered to avoid spread of resistant isolates.

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Corresponding author
*Author for correspondence: Dr B. Schulte, Institut für Medizinische Mikrobiologie und Hygiene, Eberhard-Karls-Universität, Elfriede-Aulhorn-Str. 6, D-72076 Tübingen, Germany. (Email: berit.schulte@med.uni-tuebingen.de)
References
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1. Brauers J, et al. Surveillance of linezolid resistance in Germany, 2001–2002. Clinical Microbiology and Infection 2005; 11: 3946.
2. Meka VG, Gold HS. Antimicrobial resistance to linezolid. Clinical Infectious Diseases 2004; 39: 10101015.
3. Raad II, et al. Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin. Antimicrobial Agents and Chemotherapy 2004; 48: 35833585.
4. Gonzales RD, et al. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 2001; 357: 1179.
5. Pai MP, et al. Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium. Clinical Infectious Diseases 2002; 35: 12691272.
6. Borgmann S, et al. Discrimination between epidemic and non-epidemic glycopeptide-resistant E. faecium in a post-outbreak situation. Journal of Hospital Infection 2007. Published online: 30 July 2007. doi:10.1016/j.jhin.2007.06.002.
7. Tenover FC, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. Journal of Clinical Microbiology 1995; 33: 22332239.
8. Marshall SH, et al. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrobial Agents and Chemotherapy 2002; 46: 33343336.
9. Schulte B, et al. Linezolid-resistant E. faecium isolated from an open joint fracture: a report of the first isolate from Italy? International Journal of Hygiene and Environmental Health 2005; 208: 477480.
10. Jones RN, et al. Linezolid-resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone: report from the SENTRY Antimicrobial Surveillance Program. Diagnostic Microbiology and Infectious Disease 2002; 42: 137139.
11. Rahim S, et al. Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid. Clinical Infectious Diseases 2003; 36: E146E148.
12. Bonora MG, et al. Emergence of linezolid resistance in Enterococcus faecium not dependent on linezolid treatment. European Journal of Clinical Microbiology and Infectious Diseases 2006; 25: 197198.
13. Herrero IA, Issa NC, Patel R. Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. New England Journal of Medicine 2002; 346: 867869.
14. Dobbs TE, et al. Nosocomial spread of Enterococcus faecium resistant to vancomycin and linezolid in a tertiary care medical center. Journal of Clinical Microbiology 2006; 44: 33683370.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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