Skip to main content
×
Home
    • Aa
    • Aa

Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)

  • E. C. Anderson (a1), N. T. Begg (a2), S. C. Crawshaw (a2), R. M. Hargreaves (a1), A. J. Howard (a3) and M. P. E. Slack (a1)...
Abstract
Summary

This survey defined the pattern of invasive Haemophilus influenzae infections during 1990–2 in six regions in England and Wales during the pre-vaccination era providing a baseline against which any changes in patterns of disease due to the introduction of the Haemophilus influenzae type b vaccination programme can be monitored. A total of 946 cases of invasive Haemophilus influenzae were recorded during the survey period of which almost 90 % were due to type b and most of the remainder were non-typeable. Type b infections occurred predominantly in children less than 5 years of age (88%) with the highest attack rate in male infants in the 6–11 month age group. Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates. Mortality was highest in neonates and the elderly (over 65 years of age) who were more likely to have an underlying predisposing condition than older children and adults. Children under 5 years of age had a higher case fatality rate for non-typeable than for type b infections. Ampicillin resistance was 15% and there were no cefotaxime resistant type b isolates.

Copyright
Corresponding author
* Author for correspondence: Dr R. M. Hargreaves, Oxford Public Health Laboratory, Oxford Radcliffe Hospital, Headington, Oxford OX3 9DU.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. PH Mäkelä . AK Takala , H Peltola , J Eskola . Epidemiology of invasive Haemophilus influenzae type b disease. J Infect Dis 1992; 165 (suppl 1): S26.

2. R Booy , SA Hodgson , MPE Slack , Invasive Haemophilus influenzae type b disease in the Oxford Region (1985–1991). Arch Dis Child 1993; 69: 225–8.

3. AJ Howard , KT Dunkin , JM Muser , Epidemiology of Haemophilus influenzae type b invasive disease: Wales. BMJ 1991; 303: 441–5.

4. RJ Wallace , DM Muser , EJ Septimus , Haemophilus influenzae infections in adults: characterisation of strains by serotypes, biotypes and β-lactamase production. J Infect Dis 1981; 144: 101–6.

6. H Peltola , TO Rod , K Jonsdottir , Life-threatening Haemophilus influenzae infections in Scandinavia: A five country analysis of the incidence and the main clinical and bacteriological characteristics. Rev Infect Dis 1990; 12: 708–15.

7. CV Broome . Epidemiology of Haemophilus influenzae type b infections in the United States. Pediatr Infect Dis J 1987; 6: 799–82.

8. GL Gilbert , DA Clements , SJ Broughton . Haemophilus influenzae type b infections in Victoria, Australia 1985–1987. Pediatr Infect Dis J 1990; 9: 252–7.

11. H Peltola , T Kilpi , M Anttila . Rapid disappearance of Haemophilus influenzae type b meningitis after routine childhood immunisation with conjugate vaccines. Lancet 1992: 340: 592–4.

12. R Booy , S Hodgson , L Carpenter , Efficacy of Haemophilus influenzae type b conjugate vaccine PRP-T. Lancet 1994; 344: 362–6.

13. R Booy , SA Taylor , SRM Dobson , Immunogenicity and safety of PRP-T conjugate vaccine given according to the British accelerated immunisation schedule. Arch Dis child 1992; 67: 475–8.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 1 *
Loading metrics...

Abstract views

Total abstract views: 28 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th May 2017. This data will be updated every 24 hours.