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Estimating hepatitis C infection acquired in England, 1986–2000

  • M. A. BALOGUN (a1), A. J. VYSE (a1), L. M. HESKETH (a2), G. KAFATOS (a3), J. V. PARRY (a4) (a5) and M. E. RAMSAY (a1)...

Hepatitis C is a global health problem and in the UK seroprevalence studies have mainly concentrated on specific high-risk groups. The aim of this study was to determine changes in the prevalence of antibody to hepatitis C virus in England using residual specimens collected between 1986 and 2000 reflecting the general population. A cross-sectional study design using a convenience collection of serum specimens from adult patients submitted to laboratories in the years 1986, 1991, 1996 and 2000 from a total of 19 laboratories around England were investigated. The main outcome was to determine anti-HCV prevalence and the average incidence occurring between 1986 and 2000 and factors associated with infection. Multivariable analysis of results from all years showed there was a significant difference in prevalence between males and females (P<0·001), birth cohort (P<0·001) and by health region (P<0·001). An average of 0·72% (95% CI 0–1·65%) of those susceptible to HCV born between 1950 and 1970 were estimated to have acquired the infection between 1986 and 2000. Analysis of this convenience serum collection suggests that HCV prevalence is low in the general population, and is associated with period of birth, gender and health region. There was evidence to support a low incidence of HCV infection in those born between 1950 and 1970 over the period 1986–2000 which, at the population level, equated to a substantial burden of infection (~106 000 persons). Continued surveillance and prevention targeted at injecting drug users are essential for the control of hepatitis C in the UK.

Corresponding author
*Author for correspondence: Dr M. A. Balogun, Health Protection Agency, Centre for Infections, Immunisation Department, 61 Colindale Avenue, LondonNW9 5EQ, UK. (Email:
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6. K Soldan , JAJ Barbara , J Heptonstall . Incidence of seroconversion to positivity for hepatitis C antibody in repeat blood donors in England, 1993–5. British Medical Journal 1998; 316: 14131417.

7. MA Balogun , The prevalence and genetic diversity of hepatitis C infection in antenatal clinic attenders in two regions of England. Epidemiology and Infection 2000; 125: 705712.

13. MA Balogun , The prevalence of hepatitis C in England and Wales. Journal of Infection 2002; 45: 119226.

19. PAC Maple , Immunity to diphtheria and tetanus in England and Wales. Vaccine 2001; 19: 167173.

22. H Kelly , A random cluster survey and a convenience sample give comparable estimates of immunity to vaccine preventable diseases in children of school age in Victoria, Australia. Vaccine 2002; 20: 31303136.

23. U Gungabissoon , MA Balogun , ME Ramsay . Hepatitis C virus: laboratory surveillance in England and Wales, 1992–2004. Epidemiology and Infection 2007; 135: 541548.

24. MA Balogun , A national survey of genitourinary medicine clinic attenders provides little evidence of sexual transmission of hepatitis C virus infection. Sexually Transmitted Infections 2003; 79: 301306.

28. M Sweeting , The burden of hepatitis C in England. Journal of Viral Hepatitis 2007; 14: 570576.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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