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The evaluation of a live salmonella vaccine in mice and chickens

Published online by Cambridge University Press:  15 May 2009

V. A. Knivett  and
W. K. Stevens
V. A. Knivett
Affiliation:
Twyford Laboratories Ltd., Twyford Abbey Road, London, N.W.10
W. K. Stevens
Affiliation:
Twyford Laboratories Ltd., Twyford Abbey Road, London, N.W.10
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Summary

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Mice vaccinated with a live attenuated strain of Salmonella dublin were protected against heavy challenge infections of S. dublin, S. typhimurium, S. choleraesuis and S. anatum. Oral and subcutaneous vaccination were equally effective. When day-old chicks were orally vaccinated and subsequently challenged with S. typhimurium, the growth of the challenge organism was considerably reduced or eliminated from the livers of the vaccinated chicks whereas most of the non-vaccinated were heavily infected. Field trials with vaccinated day-old chicks showed that they suffered no setbacks in growth, stress, loss of appetite or adverse side effects.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 2 , June 1971 , pp. 233 - 245
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Botes, H. J. W. (1965). Live vaccines in the control of Salmonellosis. Journal of the South African Veterinary Medical Association 36, (4), 461.Google Scholar
Collins, F. M. (1968). Cross-protection against Salmonella enteritidis infection in mice. Journal of Bacteriology 95, 1343.CrossRefGoogle ScholarPubMed
Collins, F. M., Mackaness, G. B. & Blanden, R. V. (1966). Immunity in experimental salmonellosis. Journal of Experimental Medicine 124, 601.CrossRefGoogle ScholarPubMed
Hall, M. L. M. & Taylor, J. (1970). Salmonella dublin: The relation between the living calf vaccine strain and those isolated from human and other sources. Veterinary Record 86, 534.Google Scholar
Rankin, J. D., Newman, G. & Taylor, R. J. (1966). The protection of calves against infection with S. typhimurium by means of S. dublin (Strain 51) vaccine. Veterinary Record 78, 765.Google Scholar
Smith, H. W. (1956 a). The use of live vaccines in experimental S. gallinarum infection in chickens with observations on their interference effect. Journal of Hygiene 54, 419.CrossRefGoogle Scholar
Smith, H. W. (1956 b). The immunity to Salmonella gallinarum infection in chickens produced by live cultures of members of the Salmonella genus. Journal of Hygiene 54, 433.CrossRefGoogle ScholarPubMed
Smith, H. W. (1965). The immunization of mice, calves and pigs against Salmonella dublin and Salmonella cholerae-suis infections. Journal of Hygiene 63, 117.Google Scholar
Smith, H. W. & Halls, S. (1966). The immunity produced by a rough Salmonella dublin variant against Salmonella typhimurium and Salmonella choleraesuis infection in guineapigs. Journal of Hygiene 64, 357.CrossRefGoogle ScholarPubMed