Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-05-14T13:34:04.430Z Has data issue: false hasContentIssue false
  • English
  • Français

The evaluation of hypersensitivity tests in cattle after foot-and-mouth disease vaccination

Published online by Cambridge University Press:  15 May 2009

L. Black  and
T. W. F. Pay
L. Black
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
T. W. F. Pay
Affiliation:
The Wellcome Foot and Mouth Disease Vaccine Laboratory, Pirbright, Surrey
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The response to passive cutaneous anaphylaxis, dermal hypersensitivity and intravenous provocation tests has been compared in 30, 40, 31 and 24 cattle injected with foot-and-mouth disease vaccine 0, 1, 2 and 3 times respectively, using vaccine components and other substances as test materials. Reaginic antibodies, demonstrated by passive cutaneous anaphylaxis in goats, were directed against BHK 21 cell extracts (20), hydroxypropylmethylcellulose (3) and an unidentified vaccine component (3), and distributed in 0, 5, 19 and 75% of the cattle vaccinated 0, 1, 2 and 3 times. None of the animals showed clinical signs of allergy after vaccination. When BHK 21 cell extract was injected intradermally a significant correlation was noted between the development of large weals and the presence of reagins although the size of the weals was not correlated with the reagin titres. In the case of hydroxypropylmethylcellulose a similar trend was evident. The majority of cattle with large dermal weals possessed reagins but the number of reactions was too small for statistical evaluation. Dermal reactions to sodium penicillin, sodium carboxymethylcellulose, saponin and whole vaccine occurred in both unvaccinated and vaccinated cattle but BHK 21 cell lysate and normal bovine serum provoked weals which increased in frequency according to the number of vaccinations experienced. Intravenous hydroxypropylmethylcellulose elicited a response in all the animals previously injected with certain batches of vaccine but none in those injected with other batches or in unvaccinated controls. BHK 21 cell extract intravenously produced a clinical response in half the tested animals which was uncorrelated with the results of the passive cutaneous anaphylaxis or dermal hypersensitivity tests.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 2 , April 1975 , pp. 169 - 181
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Aas, K. & Johansson, S. G. O. (1971). The radioallergosorbent test in the in vitro diagnosis of multiple reaginic allergy. A comparison of diagnostic approaches. Journal of Allergy and Clinical Immunology 48, 134.Google Scholar
Aitken, M. M. & Sanford, J. (1969). Experimental anaphylaxis in cattle. Journal of Comparative Pathology 79, 131.CrossRefGoogle ScholarPubMed
Arostegui, F. J., Caggiano, A. F. & Gatto, F. (1963). Crisis anafilactica producida por vacuna anti-aftosa II. Consideraciones clinicas. Gaceta Veterinaria, Buenos Aires 25, 308.Google Scholar
Bachofen, H., Scherrer, M., Trautlein, F. & Wyss, F. (1967). Ist das Hausstaubasthmaein Milbenasthma? Plethysmographische Untersuchungen vor und nach Asthmaprovokation mit Milbenextrakt. Deutsche Medizinische Wochenschrift 92, 1597.Google Scholar
Bahnemann, H. G., Gielhausen, H. E. & Schweckendiek, O. E. (1971). Studies on delayed-type allergy in cattle following vaccination against foot-and-mouth disease. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Ankara, Turkey, 1970. FAO, Rome.Google Scholar
Baljer, E. & Mayr, A. (1971). Statische Untersuchungen uber die im Anschluss an die Maul-und-Klauenseuche-Schutzimpfungen von 1967–1970 in Bayern aufgetretienen Storungen der Trachtigkeit. Zentralblatt für Veterinärmedizin, Reihe B 18, 293.CrossRefGoogle Scholar
Ballarini, G., Zannetti, G. & Scandiani, O. (1971). L'intradermoreazione nello studio della sensibilizzazione dei bovini al vaccino antiaftoso. Folia Veterinaria Latina 2, 283.Google Scholar
Bauer, K., Kaaden, D. R. & Mussgay, M. (1970). Experimentelle Untersuchungen über Allergien vom Spättyp nach der Schutzimpfung von Rindern mit Maul-und-Klauenseuche (MKS) – Vakzinen. Berliner und Münchener tierärztliche Wochenschrift 82, 292.Google Scholar
Bazarel, M., Orgel, H. A. & Hamburger, R. N. (1973). The influence of serum IgE levels of selected recipients, including patients with allergy, helminthiasis and tuberculosis, on the apparent P-K titre of a reaginic serum. Clinical and Experimental Immunology 14, 117.Google Scholar
Beadle, G. G. (1971). Allergy problems with foot-and-mouth disease vaccine. M.V.Sc. Thesis, University of Liverpool.Google Scholar
Beadle, G. G. & Pay, T. W. F. (1975). Immediate type hypersensitivity in cattle produced by foot-and-mouth disease vaccines. Demonstration of reaginic antibody. Research in Veterinary Science (in the Press).Google Scholar
Berg, T., Bennich, H. & Johansson, S. G. O. (1971). In vitro diagnosis of atopic allergy. I. A comparison between provocation tests and the radioallergosorbent test. International Archives of Allergy and Applied Immunology 40, 770.Google Scholar
Biliotti, G., Passaleva, A., Romagnani, S. & Ricci, M. (1972). Mites and house dust allergy. I. Comparison between house dust and mite (Dermatophagoides pteronyssinus and D. farinae) skin reactivity. Clinical Allergy 2, 109.CrossRefGoogle Scholar
Black, L., Menard, F. J. R. R., Beadle, G. G. & Pay, T. W. F. Hypersensitivity in cattle after foot and mouth disease vaccination: Response to hydroxypropyl-methylcelullose. In publication.Google Scholar
Capstick, P. B., Pau, T. W. F., Beadle, G. G., Bandau, R. & Boge, A. (1970). Some studies on allergic reactions to foot-and-mouth disease vaccine in Lower Saxony, Germany. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Brescia, Italy, 1969. FAO, Rome.Google Scholar
Code, C. F. & Hester, H. F. (1939). The blood histamine during anaphylactic shock in the horse and calf. American Journal of Physiology 127, 71.Google Scholar
de Quiroz, R., Sutmöller, P. & Barroeta, M. (1964). Factors associated with anaphylactic reaction to chicken embryo foot-and-mouth disease vaccine and Flury rabies vaccine in cattle of Venezuela. American Journal of Veterinary Research 25, 1627.Google Scholar
Dungworth, D. L. (1965). The pulmonary response of sensitised cattle to aerosol administration of antigen. Proceedings of a Symposium on Acute Bovine Pulmonary Emphysema, Laramie, Wyoming.Google Scholar
Eyal, J. & Mayer, E. (1971). Hypersensitivity in Israeli-Friesian cattle following foot-and-mouth disease vaccination. Refuah Veterinarith 28, 62.Google Scholar
Fitch, K. D., Turner, K. J. & Morton, A. R. (1972). The relationship between serum IgE levels and exercise induced asthma. Annals of Allergy 30, 497.Google ScholarPubMed
Gerlach, F. (1922). Serumkrankheit bei Rind und Pferd. Zeitschrift für Immunitätsforschung und experimentelle Therapie 34, 75.Google Scholar
Ginanni, C. & Maglione, E. (1972). Contributo allo studio delle reazione anafilattiche precoci nella vaccinazione antiafosa dei bovine. Atti Societa Italiana Buiatria 4, 162.Google Scholar
Hosen, H. (1965). Provocative nasal tests for diagnosis of inhalent allergens: correlation with skin tests and clinical symptoms. Annals of Allergy 23, 497.Google Scholar
Jensen, H. (1969). Hypersensitivity in guinea pigs induced by foot-and-mouth disease vaccine and vaccine components. Nordisk Veterinaermedicin 21, 648.Google Scholar
Leeman, W., de Weck, A. L. & Schneider, C. H. (1969). Hypersensitivity to carboxymethylcellulose as a cause of anaphylactic reactions to drugs in cattle. Nature, London 223, 621.Google Scholar
Leskowitz, M. & Lowell, F. C. (1961). A comparison of the immunologic and physiologic responses of normal and allergic individuals. Journal of Allergy 32, 152.CrossRefGoogle ScholarPubMed
Lieberman, P., Patterson, R., Metz, R. & Lucena, G. (1971). Allergic reactions to insulin. Journal of the American Medical Association 215, 1106.Google Scholar
Linblad, J. H. & Farr, R. S. (1961). The incidence of positive intradermal reactions and the demonstration of skin sensitizing antibody to extracts of ragweed and dust in humans without history of rhinitis or asthma. Journal of Allergy 32, 392.Google Scholar
Loeffler, J. A., Cawley, L. P. & Moeder, M. (1973). Serum IgE levels: correlation with skin test sensitivity. Annals of Allergy 31, 331.Google Scholar
Lorenz, R. J. & Straub, O. C. (1973). Statistiche Erhebungen über Impfschäden nach der Maul-und-Klauenseuche-Schutzimpfung im Jahr 1970. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Abt. 1, Orig. 223, 1.Google Scholar
Makarova, G. A. & Intizarov, M. M. (1966). Complications of vaccinating cattle against Foot-and-Mouth disease. Veterinariya, Moscow 43, 31. (In Russian.)Google Scholar
Mayr, A. (1971). Further investigations on foot and mouth disease allergies of the delayed type. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Ankara, Turkey, 1970. FAO, Rome.Google Scholar
Mayr, A. & Mussgay, M. (1970). Investigations on complications observed after the vaccination of cattle against foot-and-mouth disease. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Brescia, Italy, 1969. FAO, Rome.Google Scholar
Mayr, A. & Bibrack, B. (1969). Antibiotikallergien beim Tier. Berliner und Münchener tierzärztliche Wochenschrift 82, 182.Google Scholar
Mayr, A., Ringseisen, J., Baljer, B., Bibrack, B., Wallner, J. & Zimmer, H. (1969). Untersuchungen uber Art, Umfang und Ursachen von Impfschäden nach der Maul-und-Klauenseuche-Schutzimpfung in Bayern in den Jahren 1967/8. Zentralblatt für Veterinärmedizin, Reihe B 16, 487.Google Scholar
McAllen, M. K., Assem, E. S. K. & Maunsell, K. (1970). House-dust mite asthma. Results of challenge tests on five criteria with Dermatophagoides pteronyssinus. British Medical Journal ii, 501.Google Scholar
Michi, V. (1966). Manifestazioni di intolleranza alla vaccinuzione anti-aftosa nel bovino. Clinica Veterinaria, Milano 89, 112.Google Scholar
Mussgay, M. (1970). Foot-and-mouth disease vaccines, accidents and reactions. Third Inter-American Meeting on FMD and Zoonosis Control, Buenos Aires, Argentina, 1970.Google Scholar
Mussgay, M., Kaaden, O. & Bauer, K. (1970). Isolation of a sensitising lipoprotein from BHK 21 cells. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Ankara, Turkey, 1970.Google Scholar
Nilsson, S. A. (1963). Clinical, morphological and experimental studies of laminitis in cattle. Acta Veterinaria Scandinavica 4, Supplement 1.Google Scholar
Palacios, G. C. (1964). Investigaciones realizadas con los virus atenuados de la fiebre aftosa de los tipos 'O' y 'A' Vallee en Venezuela. Bulletin de l'office International des Epizooties 61, 757.Google Scholar
Stanworth, D. R. (1973). In Frontiers of Biology. Immediate Hypersensitivity. ed. Neuberger, A. and Tatum, G. L., p. 27. North Holland Publishing Co., Amsterdam and London.Google Scholar
Stenius, B. (1973). Skin and provocation tests with Dermatophagoides pteronyssinus in allergic rinitis. Comparison of prick and intracutaneous skin test methods and correlation with specific IgE. Acta Allergologica 28, 81.Google Scholar
Stenius, B., Wide, L., Seymour, W. M., Holford-Stevens, V. & Pepys, J. (1971). Clinical significance of specific IgE to common allergens. I. Relationship of specific IgE against Dermatophagoides spp. and grass pollen to skin and nasal tests, and history. Clinical Allergy 1, 37.Google Scholar
Telling, R. C., Capstick, P. B., Pay, T. W. F., Menard, F. J. R., Bandau, R., & Campos Onetti, R. C. (1972). The large-scale manufacture of FMD vaccine by the BHK cell deep suspension culture. In International Virology 2. Proceedings of the Second International Congress on Virology, Budapest, 1971. ed. Melnick, J. L.. p. 153. Karger, Busel.Google Scholar
Ubertini, B. (1970). Vaccination antiaphteuse et réactions anaphylactiques precoces. European Commission for the Control of Foot-and-Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee, Brescia, Italy, 1969. FAO, Rome.Google Scholar
Ubertini, B. & Barei, S. (1970). Anti foot-and-mouth disease vaccination and immediate anaphylactic reactions. Veterinaria Italiana 21, 366.Google Scholar
Van Arsdel, P. P. (1971). Identification of causative allergens in allergic diseases. In Immunological Disease, ed. Samter, M.. 2nd edn, p. 812. Boston: Little, Brown and Co.Google Scholar
Vanselow, N. A. (1967). Skin testing and other diagnostic procedures. In A Manual of Clinical Allergy(ed. Sheldon, J. F., Lovell, R. G. and Mathews, K. P.). Philadelphia: Saunders.Google Scholar
Wide, L., Bennich, H. & Johansson, S. G. O. (1967). Diagnosis of allergy by an in vitro test for allergic antibodies. Lancet ii, 1105.Google Scholar