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Evolutionary history of Ebola virus

  • Y. H. LI (a1) and S. P. CHEN (a2)

Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.

Corresponding author
* Author for correspondence: Dr S. P. Chen, Department of Laboratory Medicine, Affiliated Hospital of the Academy of Military Medical Sciences, No. 8, Dongdajie Street, Fengtai District, Beijing 100071, PR China. (Email:
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1. Sanchez, A, et al. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proceedings of the National Academy of Sciences USA 1996; 93: 36023607.
2. Towner, JS, et al. Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda. PLoS Pathogens 2008; 4: e1000212.
3. Fisher-Hoch, SP, et al. Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain. Journal of Infectious Diseases 1992; 166: 753763.
4. Feldmann, H, et al. Ebola haemorrhagic fever. Lancet 2011; 377: 849862.
5. Sanchez, A, et al. Filoviridae: Marburg and Ebola viruses. In: Knipe, DM, Howley, PM, eds. Fields Virology. Philidelphia: Lippincott Williams and Williams, 2007, pp. 14091448.
6. Georges-Courbot, MC, et al. Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon. Emerging Infectious Diseases 1997; 3: 5962.
7. Suzuki, Y, et al. The origin and evolution of Ebola and Marburg viruses. Molecular Biology and Evolution 1997; 14: 800806.
8. Volchkov, V, et al. Emergence of subtype Zaire Ebola virus in Gabon. Virology 1997; 232: 139144.
9. Wittmann, TJ, et al. Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants. Proceedings of the National Academy of Sciences USA 2007; 104: 1712317127.
10. Baron, RC, et al. Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread. Bulletin of the World Health Organization 1983; 61: 9971003.
11. Johnson, KM. Ebola haemorrhagic fever in Zaire, 1976. Bulletin of the World Health Organization 1978; 56: 271293.
12. Simpson, DIH. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bulletin of the World Health Organization 1978; 56: 247270.
13. Jahrling, PB, et al. Preliminary report: isolation of Ebola virus from monkeys imported to USA. Lancet 1990; 335: 502505.
14. Miranda, ME, et al. Epidemiology of Ebola (subtype Reston) virus in the Philippines, 1996. Journal of Infectious Diseases 1996; 179: 115119.
15. Rollin, PE, et al. Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States. Journal of Infectious Diseases 1999; 179: 108114.
16. Barrette, RW, et al. Discovery of swine as a host for the Reston ebolavirus. Science 2009; 325: 204206.
17. Leroy, EM, et al. Fruit bats as reservoirs of Ebola virus. Nature 2005; 438: 575576.
18. Swanepoel, R, et al. Experimental inoculation of plants and animals with Ebola virus. Emerging Infectious Diseases 1996; 2: 321325.
19. Biek, R, et al. Recent common ancestry of Ebola Zaire virus found in a bat reservoir. PLoS Pathogens 2006; 2: e90.
20. Walsh, PD, et al. Wave-like spread of Ebola Zaire. PLoS Biology 2005; 3: e371.
21. Tamura, K, et al. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Molecular Biology and Evolution 2007; 24: 15961599.
22. Schmidt, HA, et al. TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing. Bioinformatics 2002; 18: 502504.
23. Drummond, AJ, et al. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evolutionary Biology 2007; 7: 214.
24. Darriba, D, et al. jModelTest 2: more models, new heuristics and parallel computing. Nature Methods 2012; 9: 772.
25. Pond, SL, et al. Datamonkey: rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics 2005; 21: 25312533.
26. Sanchez, A, et al. Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda. Virus Research 2005; 113: 1625.
27. Taylor, DJ, et al. Filoviruses are ancient and integrated into mammalian genomes. BMC Evolutionary Biology 2010; 10: 193.
28. Hayman, DTS, et al. Long-term survival of an urban fruit bat seropositive for Ebola and lagos bat viruses. PLoS ONE 2010; 5: e1978.
29. Hayman, DTS, et al. Ebola virus antibodies in fruit bats, Ghana, West Africa. Emerging Infectious Diseases 2012; 18: 12071209.
30. Leroy, EM, et al. Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007. Vector Borne Zoonotic Diseases 2009; 9: 723727.
31. Watanabe, Y, et al. The changing nature of avian influenza A virus (H5N1). Trends in Microbiology 2012; 20: 1120.
32. Gao, R, et al. Human infection with a novel avian-origin influenza A (H7N9) virus. New England Journal of Medicine 2013; 368: 18881897.
33. Le, Guenno B, et al. Isolation and partial characterization of a new strain of Ebola virus. Lancet 1995; 345: 12711274.
34. Tsetsarkin, KA, et al. Chikungunya virus: evolution and genetic determinants of emergence. Current Opinion in Virology 2011; 1: 310317.
35. Sun, M, et al. Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China. PLoS ONE 2012; 7: e36577.
36. Leal, E, et al. Selective pressures of human immunodeficiencey virus type 1 (HIV-1) during pediatric infection. Infection Genetics and Evolution 2007; 7: 694707.
37. Wei, K, et al. Evolution and adaptation of hemagglutinin gene of human H5N1 influenza virus. Virus Genes 2012; 44: 450458.
38. Ping, J, et al. Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse. PLoS ONE 2011; 6: e21740.
39. Botosso, VF, et al. Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus. PLoS Pathogens 2009; 5: e1000254.
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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